In modern large-scale networks that there are many autonomous systems, dynamic routing protocol used more often than static routing protocol. The most effective and efficient routing protocol is needed to support modern network on a large scale. This research was conducted to compare the performance of a combination of internal with external routing protocol by using GNS3. The parameters used in this study is throughput, jitter, packet loss, and network convergence. To get the good value of QoS (Quality of Service), the value of throughput, jitter and packet loss should be kept to a minimum. The researche that have been done among other entitled Performance Evaluation of Routing Protocol RIPng, OSPFv3, and EIGRP IPv6 Networking discuss the comparison between internal routing protocol with the parameters of throughput, jitter, and packet loss. The results of this research indicate that the OSPF routing protocol has the smallest value of network convergence. Then a combination of routing protocol OSPF-BGP has the highest throughput, lowest packet loss, and smallest jitter value.