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Use of solid-phase inhomogeneities to increase the efficiency of ultrasonic therapy of oncological diseases

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Abstract

Authors’ concepts on the use of solid-phase sonosensitizer nanoinclusions in biological structures as ultrasonic energy concentrators in the therapy of oncological diseases are developed. The possibility of directed synthesis of nanoparticles and their aggregates in tumor tissue depending on its growth features is discussed. It was found that acoustic effects in polymer structures containing solid-phase inclusions depend on the nature of these inclusions and their bond with the polymer matrix. Using model gel systems, it was shown that solid-phase sonosensitizers enhance local thermal effects and amplitude-dependent scattering of ultrasound during its propagation in gel. Experimental studies on animals showed that the ultrasound exposure of malignant tumors containing nanoparticles of gold and some complex compounds results in a significant therapeutic effect.

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Authors and Affiliations

  1. Chemistry Department, Moscow State University, Moscow, 119991, Russia

    A. L. Nikolaev, A. V. Gopin, V. E. Bozhevol’nov & I. V. Melikhov

  2. Blokhin Russian Oncological Scientific Center, Russian Academy of Medical Science, Kashirskoe sh. 24, Moscow, 115478, Russia

    E. M. Treshchalina & N. V. Andronova

Authors
  1. A. L. Nikolaev
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  2. A. V. Gopin
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  3. V. E. Bozhevol’nov
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  4. E. M. Treshchalina
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  5. N. V. Andronova
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  6. I. V. Melikhov
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Corresponding author

Correspondence to A. L. Nikolaev.

Additional information

Original Russian Text © A.L. Nikolaev, A.V. Gopin, V.E. Bozhevol’nov, E.M. Treshchalina, N.V. Andronova, I.V. Melikhov, 2009, published in Akusticheskiĭ Zhurnal, 2009, Vol. 55, No. 4–5, pp. 565–574.

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Nikolaev, A.L., Gopin, A.V., Bozhevol’nov, V.E. et al. Use of solid-phase inhomogeneities to increase the efficiency of ultrasonic therapy of oncological diseases. Acoust. Phys. 55, 575–583 (2009). https://doi.org/10.1134/S1063771009040149

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  • DOI: https://doi.org/10.1134/S1063771009040149

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