Abstract
Plasma renin activity (PRA) was measured by radio-immunoassay of Angiotensin I(AI) production; plasma aldosterone concentration (PAldo) was also measured by radio-immunoassay.
It was found that in healthy children on free diets diets over the age of 1 year, the upper limit of PRA was about 500 pg AI/ml/hr, but in infants much higher levels were observed, up to 3000 pg AI/ml/hr. There was a positive correlation between PRA and sodium turnover, estimated from the urinary sodium/creatinine ratio. The upper limit of pAldo in normal children aged over 1 year was 16 ng/100ml. but in the infants was 60 ng/100ml.
PRA was in the range from 1000-2000 pg AI/ml/ hr in several hypertensive children, without PAldo, necessarily being above the upper limit of normal. On the other hand, in children with salt-losing states PRA was much greater usually over 10,000 pg AI/ml/hr, and in the majority of these children PAldo, was over 30 ng/100ml.
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Dillon, M., Ryness, J. & Barratt, T. Plasma renin activity and aldosterone concentration in children. Pediatr Res 8, 903 (1974). https://doi.org/10.1203/00006450-197411000-00047
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DOI: https://doi.org/10.1203/00006450-197411000-00047
