Heme oxygenase activity in prematures with Oxygen Radical Disease 59

BACKGROUND: Induction of heme oxygenase (HOX) enzyme, the 32 kD stress protein as protection against heme toxicity and adaptation to oxidative stress has been proven in experimental conditions.

SUBJECTS: We studied the role of HOX activity in 40 arteficially ventillated premature infants (29.9±2 ws of gestation, 1502±358 g bw) with adaptational troubles. IRDS, intraventricular hemorrhage on the 1st, 3rd, and 5th days.

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