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Tumor Suppressor Gene-Inducible Cell Lines

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Tumor Suppressor Genes

Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 223))

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Abstract

In a noncancerous mammalian cell, the growth-promoting effects of proto-oncogenes are counterbalanced by the growth-constraining effects of tumor suppressor genes (TSGs). The net result is a masterfully orchestrated display of cell proliferation in the absence of tumorigenesis. The significance of this relationship is most evident in tumor cells, where the accumulation of genetic mutations has upset this critical balance of power.

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Author information

Authors and Affiliations

  1. Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL

    Michael Dohn, Susan Nozell, Amy Willis & Xinbin Chen

Authors
  1. Michael Dohn
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  2. Susan Nozell
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  3. Amy Willis
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  4. Xinbin Chen
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Editor information

Editors and Affiliations

  1. Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA

    Wafik S. El-Deiry MD, PhD

  2. Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA

    Wafik S. El-Deiry MD, PhD

  3. Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA

    Wafik S. El-Deiry MD, PhD

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© 2003 Humana Press Inc.

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Dohn, M., Nozell, S., Willis, A., Chen, X. (2003). Tumor Suppressor Gene-Inducible Cell Lines. In: El-Deiry, W.S. (eds) Tumor Suppressor Genes. Methods in Molecular Biology™, vol 223. Humana Press. https://doi.org/10.1385/1-59259-329-1:221

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  • DOI: https://doi.org/10.1385/1-59259-329-1:221

  • Publisher Name: Humana Press

  • Print ISBN: 978-0-89603-987-2

  • Online ISBN: 978-1-59259-329-3

  • eBook Packages: Springer Protocols

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