Investigating hormesis, aging, and neurodegeneration: From bench to clinics
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Vittorio Calabrese
, Uwe Wenzel
Abstract
Mitochondria-derived reactive oxygen species production at a moderate physiological level plays a fundamental role in the anti-aging signaling, due to their action as redox-active sensors for the maintenance of optimal mitochondrial balance between intracellular energy status and hormetic nutrients. Iron regulatory protein dysregulation, systematically increased iron levels, mitochondrial dysfunction, and the consequent oxidative stress are recognized to underlie the pathogenesis of multiple neurodegenerative diseases, such as Parkinson’s disease and Alzheimer’s disease. Central to their pathogenesis, Nrf2 signaling dysfunction occurs with disruption of metabolic homeostasis. We highlight the potential therapeutic importance of nutritional polyphenols as substantive regulators of the Nrf2 pathway. Here, we discuss the common mechanisms targeting the Nrf2/vitagene pathway, as novel therapeutic strategies to minimize consequences of oxidative stress and neuroinflammation, generally associated to cognitive dysfunction, and demonstrate its key neuroprotective and anti-neuroinflammatory properties, summarizing pharmacotherapeutic aspects relevant to brain pathophysiology.
1 Introduction
Reduction of cellular expression and activity of antioxidant proteins and the resulting increase of oxidative stress are fundamental causes in the aging processes and neurodegenerative diseases [1]. There have been numerous theories to explain the aging process. Although several lines of evidence suggest that accumulation of oxidative molecular damage is a primary causal factor in senescence, it is increasingly evident that the mitochondrial genome may play a key role in aging and neurodegenerative diseases. Mitochondrial dysfunction is characteristic of several neurodegenerative disorders, and evidence for mitochondria being a site of damage in neurodegenerative disorders is partially based on decreases in respiratory chain complex activities in Parkinson’s disease (PD), Alzheimer’s disease (AD), and Huntington’s disease [2]. Such defects in respiratory complex activities, possibly associated with oxidant/antioxidant balance perturbation, are thought to underlie defects in energy metabolism and induce cellular degeneration. Mitochondria play also a key role in the anti-aging signaling, as moderate reactive oxygen species (ROS) production operates as redox sensors of intracellular nutrients and energy status to maintain optimal mitochondrial balance, although further understanding of mitochondrial supercomplex dynamics and functional energy metabolism, as well as physiological ROS generation and their regulation by nutrition and caloric intake are yet to be fully elucidated.
During the last few years, cellular oxidant/antioxidant balance has become the subject of intense study, particularly by those interested in brain aging and in neurodegenerative mechanisms [3]. Several lines of evidence suggest that accumulation of oxidative molecular damage is a causal factor in senescence. The direct evidence for this hypothesis is that overexpression of antioxidative genes for Cu, Zn-superoxide dismutase and catalase in transgenic Drosophila melanogaster prolongs the life span, retarding the age-associated accumulation of oxidative damage [3]. Among the correlative evidence supporting the involvement of oxidative stress are the following: (1) oxidative molecular damage to DNA and proteins increases exponentially with age, and concomitantly, the rates of mitochondrial O⋅−2 and H2O2 generation as well as the susceptibility of tissues to experimentally induced oxidative stress are increased; (2) experimental regimens that extend life span, such as caloric restriction in mammals and reduction of metabolic rate in insect, decrease the accumulation rates of oxidative damage; (3) mitochondria make rather contradictory contributions to cell survival, as they are crucial for cellular energy metabolism, produce at significant rate oxygen and nitrogen free radicals, but also undergoing dynamic changes, through fusion and fission to adapt to different cellular states, modulate cellular neural cell signaling, brain aging, and neuronal cell death. An emerging interest is now focusing on exogenous small molecules that are capable of activating these systems as a novel target to minimize deleterious consequences associated with free radical-induced cell damage, such as during neurodegeneration or in cancer [4]. Hormesis has been conceptually adopted in biology and medicine to encompass adaptive responses of cells and organisms to moderate stress and, as such, will foster future research in applied neurosciences [3,4]. When mild stress occurs, this induces the activation of signaling pathways which are associated with the setting of a programmed cell life survival and withstanding to more severe stress conditions. The concept of hormesis has emerged as a significant dose–response model in toxicology and pharmacology [5]. The enhanced recognition of hormesis has occurred principally because traditional dose–response models such as the threshold model have not been able to account for the occurrence of nonrandom biological activity below well-established thresholds of response [6]. The hormetic dose–response challenges long-standing beliefs about the nature of the dose–response in a low-dose zone, having the potential to affect significantly the design of pre-clinical studies and clinical trials as well as strategies for optimal patient dosing in the treatment of numerous diseases. The hormetic dose–response may be reliably described as stimulation in the low-dose zone, followed by an inhibitory response at higher doses [6]. The magnitude of the stimulatory response at maximum is typically modest, being only about 30–60% above that of the control response (Figure 1). The vast majority of stimulatory responses are less than twice the control value [7]. This is the most distinguishing characteristic of the hormetic dose–response, being its most consistent and reliable feature.

Dose–response curve depicting the quantitative features of hormesis.
2 Mitochondria and ROS in aging and neurodegenerative disorders
Harman first proposed that mitochondria may have a central role in the process of aging [8]. According to this theory, free radicals generated through mitochondrial metabolism can act as a causative factor of abnormal function and cell death. Mitochondria are the cell’s most significant source of oxidants and in vitro studies have indicated that approximately 1–2% of electron flow through the ETC results in the univalent generation of superoxide. Moreover, various toxins in the environment can injure mitochondrial enzymes, leading to increased generation of free radicals that over the life span would eventually play a major role in aging [4]. Mitochondria are evolutionary organelles regulating brain energy metabolism and are central to neuronal signaling pathways, brain aging, and apoptotic cell death [3]. These organelles undergo continuous morphological and structural remodeling, pertaining to mitochondrial dynamics, where fusion and fission processes are essential events to assure proper functioning in different redox states of cells [9]. The classically recognized mitochondrial function is the synthesis of ATP for energizing endergonic reactions; the other is the generation of ROS which may compromise the long-term survival of cells and constitute a major underlying cause of the aging process. Indeed, these two rather conflicting functions are part of the same process, namely mitochondrial respiration. More than 95% of the O2 taken up by the human body is used by mitochondrial cytochrome oxidase which adds four electrons to oxygen to generate a molecule of water. Cytochrome oxidase normally does not release ROS into its surroundings. However, a number of investigations have indicated that brain mitochondria undergo oxidative stress damage and a decrease in cytochrome c oxidase activity during aging [3]. Increasing evidence sustains the hypothesis that mitochondrial energy metabolism underlies the pathogenesis of neurodegenerative diseases. Decreased complex I activity is reported in the substantia nigra of post-mortem samples obtained from patients with PD [10]. Similarly, impaired complex IV activity has been demonstrated in AD [11]. Increased free radical-induced oxidative stress has been associated with the development of these disorders, and a large body of evidence suggests that NO˙ plays a central role. Loss of nigral glutathione is considered an early and crucial event in the pathogenesis of PD [12], and as a consequence, decreased peroxynitrite scavenging may also occur. Therefore, such perturbations in thiol homeostasis may constitute the starting point for a vicious cycle leading to excessive ONOO− generation in PD. In support of this, it has been reported that the selective inhibition of nNOS prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinsonism in experimental animals [13].
3 Nrf2 signaling and the vitagene network
Among the cellular pathways conferring protection against oxidative stress, a key role is played by the products of vitagenes [1,14,15]. These include members of the heat shock protein (Hsp) family, such as heme oxygenase-1 and Hsp72, sirtuins, and the thioredoxin/thioredoxin reductase system [4,14,15]. The cellular stress response is regulated at the transcriptional, translational, and post-translational levels by a family of heat shock transcription factors (HSFs) that are expressed and maintained in an inactive state under non-stress conditions. HSFs, essential for all organisms to survive to acute or chronic stress, are also important for normal development and lifespan-enhancing pathways, and the repertoire of HSF targets has thus expanded well beyond the heat shock genes. Post-translational regulation of HSFs is emerging to integrate the metabolic state of the cell with stress biology, whereby controlling fundamental aspects of the health of the proteome and aging [4,15]. In addition to this, the KEAP1/Nrf2/ARE pathway is the basis of the cellular defense. Induction of this pathway has been shown to be protective against various stress conditions. On the other side, under conditions of Nrf2 deficiency with failure to upregulate this pathway, increased sensitization and accelerated disease pathogenesis have been demonstrated. Transcription factor Nrf2, under basal conditions, is continuously targeted for ubiquitination and proteasomal degradation by KEAP1, a protein acting as a repressor. It is well defined now that many inducers of the Nrf2 pathway chemically modify specific cysteine residues within KEAP1, leading to the loss of its ability to target Nrf2 for degradation. Subsequently, Nrf2 levels accumulate, enter the nucleus, bind as a heterodimer with a small Maf transcription factor to antioxidant response elements (AREs, specific sequences that are present in the promoter regions of NRF2-target genes), and hence activate transcription of NRF2-dependent vitagenes which encode a large network of cytoprotective proteins, including those that are involved in the metabolism and transport of a wide array of endo- and xenobiotics, proteins that have antioxidant functions, as well as those that participate in the synthesis, utilization, and regeneration of glutathione and NAD(P). Several phytochemicals act through the activation of transcription factor Nrf2 (Figure 2). Under basal conditions, these protective systems do not operate at maximum capacity but can be induced to higher activity levels by redox-active compounds, such as hormetic nutrients, thus reducing the risks of developing malignancies and multiple chronic diseases.

The Keap1/Nrf2/ARE pathway. (a) Under basal conditions, Nrf2 is bound to Keap1, a cytoplasmic repressor that targets Nrf2 for ubiquitination and proteasomal degradation. (b) Polyphenols, as molecules inducers, react with cysteine residues of Keap1, which operate as sensors, and hence induce stabilization of Nrf2, via entering into nucleus, where this transcriptional factor, by binding to the ARE, promotes transcriptional activation of cytoprotective vitagenes.
4 Nutritional polyphenols and their therapeutic potential
The intake of nutritional polyphenols has been shown to reduce the risk of vascular disease and enhance hippocampus-dependent cognitive function [16]. Continuous consumption of these foods can reduce the risk of chronic diseases and promote a healthy lifestyle [17]. Additionally, studies have found that the beneficial effects on the circulatory system, metabolic system, and brain function can persist for several hours after ingestion [18]. The mechanism by which nutritional polyphenols exert their biological activity is unknown due to their extremely low bioavailability [18]. However, recent studies suggest that their sensory properties, such as bitterness and astringency, act as mild stressors and maintain homeostasis [19]. Recently, it has been seen that mushrooms containing polyphenols, olive oil polyphenols, sulforaphane, or saffron counteract oxidative stress, mitochondrial dysfunction, and neuroinflammation closely connected to the initiation and progression of various brain disease conditions. Interestingly, these compounds exert antioxidant or toxic effects depending on their endogenous concentration and act according to the emerging principles of hormetic nutrition [20]. Following the hormetic paradigm, natural polyphenolic substances at low doses act as antioxidants in a wide range of brain diseases, this occurring through upregulation of Nrf2 signaling pathway and increased expression of vitagenes, such as NAD(P)H-quinone oxidoreductase (NQO1), glutathione transferase (GT), GPx, heme oxygenase-1 (HO-1), sirtuin-1 (Sirt1), and thioredoxin (Trx) system. This network, by blocking ROS production, plays a fundamental role in the free radical species metabolism, as well as in the biotransformation of xenobiotics, ultimately preventing neuronal cell death associated with neurotoxic damage. Importantly, dysregulation of the Nrf2 pathway in the central nervous system can be a prominent cause of selective neuronal susceptibility under oxidative and neuroinflammatory conditions, due to the high vulnerability of specific neuronal systems to oxidant/antioxidant balance perturbation. The neurobiological importance of mechanisms targeting Nrf2/vitagene pathways, relevant to the development of new therapeutical strategies capable of suppressing oxidative stress and neuroinflammation and the consequent cognitive dysfunction, occurring in all major neurodegenerative conditions, is here highlighted, underscoring innovative pharmacological perspectives based on neuronutrition in the hormetic low dose relevant to brain disorder management [19,21,22].
5 Caenorhabditis elegans as a model organism
In the nematode C. elegans such hormetic mechanisms can be perfectly studied based on its simplicity and genetic tractability. Models for AD and PD have been constructed through promoter, thus cell-specific transgenic expression of human genes encoding the amyloidogenic proteins β-amyloid or α-synuclein, respectively [23]. Transgenes encoding the pathogenic proteins in fusion with a fluorescent marker allow the degeneration of affected cells in the transparent organism by fluorescence microscopy. In a C. elegans strain expressing β-amyloid in body wall muscle cells, for instance, an olive-derived extract containing 20% of the polyphenol hydroxytyrosol reduces the rate of amyloid-β aggregates and also the β-amyloid-induced paralysis [24]. Those pathogenicity-reducing activities of hydroxytyrosol were diminished by the knockdown of two genes typically involved in hormetic responses, skn-1/nrf-2 and hsp-16.2 [25]. Similar results were obtained for the caloric restriction mimetic resveratrol from red grapes, where the inhibition of unfolded protein response and of proteasomal degradation and autophagy has been shown to prevent the activities of the polyphenol [16]. The polyphenol phlorizin from apple skins in dependence on Skn-1/Nrf-2 triggers autophagy and prevents β-amyloid-induced toxicity in an AD model but also the degeneration of dopaminergic neurons in a PD model of C. elegans [17]. Induction of autophagy was also proven as crucial for the neuroprotective effects of chlorogenic acid, an ester of caffeic acid and quinic acid, and a major phenolic compound in coffee [18]. Chlorogenic acid thereby reduced α-synuclein aggregation, improved motor disorders, and decreased ROS in a PD C. elegans model [18].
6 Conclusions
A large body of experimental evidence suggests that a functional interplay between ROS levels generated by mitochondria and various antioxidant pathways exert modulating effects on lifespan, ensuring brain-healthy aging and this phenomenon is hormesis based [26,27,28]. There is widespread evidence that the hormetic activation profile for ROS generation is in the 15–35% range greater than control values. Increases of ROS in the 200–250% range are associated with toxicity, that is, the upper end of the hormetic dose–response. The ROS-mediated hormetic stimulation is general, being reported for a wide range of chemical (e.g., caffeic acid, copper ions) and physical agents (i.e., non-ionizing and ionizing radiation), all conforming to this modest ROS increase for their stimulatory features than conform to the quantitative characteristic of the hormetic dose–response [29]. This striking commonality led Duan et al. [30] to state that “low concentrations of ROS from all sources exert a positive effect on cell proliferation.” Redox-active mechanisms based on oxidant/antioxidant balance, through cellular redox signaling, are subject of increasing interest in mitochondrial medicine, as a perturbation of this equilibrium is at the origin of several oxidant disorders, including chronic neurodegenerative diseases where ROS balance disruption is associated with mitochondrial dysfunction [1]. Consistent with this notion, based on the application of innovative medical and scientific technologies, anti-aging medicine emerges as a new science, conceptually defined as a medical specialty aimed at the early detection, prevention, treatment, and reversal of age-related disorders. It is a model of productive healthcare where innovation and research are conjugated to model new approaches capable of prolonging the healthy life span of humans. In this century, due to neurodegenerative diseases, cancer, and metabolic and heart diseases, assuring a healthy quality of life during aging is a crucial matter, as age-related pathologies have a substantially increasing impact on healthcare systems worldwide. It is well recognized to date how slowing of aging and age-related disorders can abolish more than 50% of all pathologies [2]. This can be achieved with strategies focusing on preventive and personalized medicine, delaying or reversing major age-associated neurodegenerative disorders. Translational application of these anti-aging and mitochondrial medicine concepts should allow efficient prevention, at early stages, of any of these diseases, where integration of detection, therapeutic interventions, and reversal of aging-related pathologies produce enhancement in the quality and in the extension of human lifespan, thus providing, at the same time, a new model for proactive healthcare policies for all this new millennium. Hormetic mechanisms are central to the possibility of targeted therapeutics in a pathway-specific manner at cell, tissue, and organismic levels and are appropriate intervention points in the AD and PD disease processes [31,32]. We propose and refine the potential of the therapeutic use of hormetic neuronutrients, such as natural polyphenols, in particular those highly active as Nrf2 inducers, primarily acting as Keap1-Nrf2 protein–protein interaction inhibitors, yet promoting Keap-1 degradation to regulate activation of Nrf2 related pathway. In this biochemical context, nutritional polyphenols are considered neuronutrients endowed with high potential as pharmacological modulators of neuroinflammation processes, thus providing a solid rationale for treating neurodegenerative disorders.
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Funding information: This study was supported by grants from “Piano di incentivi per la Ricerca, Linea Intervento 2 PIACERI, 2020–2022”, University of Catania, Italy; and MUR PRIN 2022FWB4EX.
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Author contributions: Conceptualization: V.C.; N.O.; U.W., E.J.C.; Data curation: L.N.; Gi.F.; Ga. F.; Funding acquisition: V.C.; Resources: V.C.; Methodology: T.P., T.F.; U.M.J; Project administration: U.M.J.; T.F.; Supervision: V.C.; E.J.C.; Writing—original draft: V.C.; N.O.; U.W.; E.J.C. All authors have read and agreed to the published version of the manuscript.
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Conflict of interest: Vittorio Calabrese serves as Editor in Chief of Open Medicine, but it did not influenced peer-review process. Authors state no conflict of interest.
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Data availability statement: Data sharing is not applicable to this article as no datasets were generated or analysed during the current study.
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- Analgesia nociception index is an indicator of laparoscopic trocar insertion-induced transient nociceptive stimuli
- High STAT4 expression correlates with poor prognosis in acute myeloid leukemia and facilitates disease progression by upregulating VEGFA expression
- Factors influencing cardiovascular system-related post-COVID-19 sequelae: A single-center cohort study
- HOXD10 regulates intestinal permeability and inhibits inflammation of dextran sulfate sodium-induced ulcerative colitis through the inactivation of the Rho/ROCK/MMPs axis
- Mesenchymal stem cell-derived exosomal miR-26a induces ferroptosis, suppresses hepatic stellate cell activation, and ameliorates liver fibrosis by modulating SLC7A11
- Endovascular thrombectomy versus intravenous thrombolysis for primary distal, medium vessel occlusion in acute ischemic stroke
- ANO6 (TMEM16F) inhibits gastrointestinal stromal tumor growth and induces ferroptosis
- Prognostic value of EIF5A2 in solid tumors: A meta-analysis and bioinformatics analysis
- The role of enhanced expression of Cx43 in patients with ulcerative colitis
- Choosing a COVID-19 vaccination site might be driven by anxiety and body vigilance
- Role of ICAM-1 in triple-negative breast cancer
- Cost-effectiveness of ambroxol in the treatment of Gaucher disease type 2
- HLA-DRB5 promotes immune thrombocytopenia via activating CD8+ T cells
- Efficacy and factors of myofascial release therapy combined with electrical and magnetic stimulation in the treatment of chronic pelvic pain syndrome
- Efficacy of tacrolimus monotherapy in primary membranous nephropathy
- Mechanisms of Tripterygium wilfordii Hook F on treating rheumatoid arthritis explored by network pharmacology analysis and molecular docking
- FBXO45 levels regulated ferroptosis renal tubular epithelial cells in a model of diabetic nephropathy by PLK1
- Optimizing anesthesia strategies to NSCLC patients in VATS procedures: Insights from drug requirements and patient recovery patterns
- Alpha-lipoic acid upregulates the PPARγ/NRF2/GPX4 signal pathway to inhibit ferroptosis in the pathogenesis of unexplained recurrent pregnancy loss
- Correlation between fat-soluble vitamin levels and inflammatory factors in paediatric community-acquired pneumonia: A prospective study
- CD1d affects the proliferation, migration, and apoptosis of human papillary thyroid carcinoma TPC-1 cells via regulating MAPK/NF-κB signaling pathway
- miR-let-7a inhibits sympathetic nerve remodeling after myocardial infarction by downregulating the expression of nerve growth factor
- Immune response analysis of solid organ transplantation recipients inoculated with inactivated COVID-19 vaccine: A retrospective analysis
- The H2Valdien derivatives regulate the epithelial–mesenchymal transition of hepatoma carcinoma cells through the Hedgehog signaling pathway
- Clinical efficacy of dexamethasone combined with isoniazid in the treatment of tuberculous meningitis and its effect on peripheral blood T cell subsets
- Comparison of short-segment and long-segment fixation in treatment of degenerative scoliosis and analysis of factors associated with adjacent spondylolisthesis
- Lycopene inhibits pyroptosis of endothelial progenitor cells induced by ox-LDL through the AMPK/mTOR/NLRP3 pathway
- Methylation regulation for FUNDC1 stability in childhood leukemia was up-regulated and facilitates metastasis and reduces ferroptosis of leukemia through mitochondrial damage by FBXL2
- Correlation of single-fiber electromyography studies and functional status in patients with amyotrophic lateral sclerosis
- Risk factors of postoperative airway obstruction complications in children with oral floor mass
- Expression levels and clinical significance of serum miR-19a/CCL20 in patients with acute cerebral infarction
- Physical activity and mental health trends in Korean adolescents: Analyzing the impact of the COVID-19 pandemic from 2018 to 2022
- Evaluating anemia in HIV-infected patients using chest CT
- Ponticulus posticus and skeletal malocclusion: A pilot study in a Southern Italian pre-orthodontic court
- Causal association of circulating immune cells and lymphoma: A Mendelian randomization study
- Assessment of the renal function and fibrosis indexes of conventional western medicine with Chinese medicine for dredging collaterals on treating renal fibrosis: A systematic review and meta-analysis
- Comprehensive landscape of integrator complex subunits and their association with prognosis and tumor microenvironment in gastric cancer
- New target-HMGCR inhibitors for the treatment of primary sclerosing cholangitis: A drug Mendelian randomization study
- Population pharmacokinetics of meropenem in critically ill patients
- Comparison of the ability of newly inflammatory markers to predict complicated appendicitis
- Comparative morphology of the cruciate ligaments: A radiological study
- Immune landscape of hepatocellular carcinoma: The central role of TP53-inducible glycolysis and apoptosis regulator
- Serum SIRT3 levels in epilepsy patients and its association with clinical outcomes and severity: A prospective observational study
- SHP-1 mediates cigarette smoke extract-induced epithelial–mesenchymal transformation and inflammation in 16HBE cells
- Acute hyper-hypoxia accelerates the development of depression in mice via the IL-6/PGC1α/MFN2 signaling pathway
- The GJB3 correlates with the prognosis, immune cell infiltration, and therapeutic responses in lung adenocarcinoma
- Physical fitness and blood parameters outcomes of breast cancer survivor in a low-intensity circuit resistance exercise program
- Exploring anesthetic-induced gene expression changes and immune cell dynamics in atrial tissue post-coronary artery bypass graft surgery
- Empagliflozin improves aortic injury in obese mice by regulating fatty acid metabolism
- Analysis of the risk factors of the radiation-induced encephalopathy in nasopharyngeal carcinoma: A retrospective cohort study
- Reproductive outcomes in women with BRCA 1/2 germline mutations: A retrospective observational study and literature review
- Evaluation of upper airway ultrasonographic measurements in predicting difficult intubation: A cross-section of the Turkish population
- Prognostic and diagnostic value of circulating IGFBP2 in pancreatic cancer
- Postural stability after operative reconstruction of the AFTL in chronic ankle instability comparing three different surgical techniques
- Research trends related to emergence agitation in the post-anaesthesia care unit from 2001 to 2023: A bibliometric analysis
- Frequency and clinicopathological correlation of gastrointestinal polyps: A six-year single center experience
- ACSL4 mediates inflammatory bowel disease and contributes to LPS-induced intestinal epithelial cell dysfunction by activating ferroptosis and inflammation
- Affibody-based molecular probe 99mTc-(HE)3ZHER2:V2 for non-invasive HER2 detection in ovarian and breast cancer xenografts
- Effectiveness of nutritional support for clinical outcomes in gastric cancer patients: A meta-analysis of randomized controlled trials
- The relationship between IFN-γ, IL-10, IL-6 cytokines, and severity of the condition with serum zinc and Fe in children infected with Mycoplasma pneumoniae
- Paraquat disrupts the blood–brain barrier by increasing IL-6 expression and oxidative stress through the activation of PI3K/AKT signaling pathway
- Sleep quality associate with the increased prevalence of cognitive impairment in coronary artery disease patients: A retrospective case–control study
- Dioscin protects against chronic prostatitis through the TLR4/NF-κB pathway
- Association of polymorphisms in FBN1, MYH11, and TGF-β signaling-related genes with susceptibility of sporadic thoracic aortic aneurysm and dissection in the Zhejiang Han population
- Application value of multi-parameter magnetic resonance image-transrectal ultrasound cognitive fusion in prostate biopsy
- Laboratory variables‐based artificial neural network models for predicting fatty liver disease: A retrospective study
- Decreased BIRC5-206 promotes epithelial–mesenchymal transition in nasopharyngeal carcinoma through sponging miR-145-5p
- Sepsis induces the cardiomyocyte apoptosis and cardiac dysfunction through activation of YAP1/Serpine1/caspase-3 pathway
- Assessment of iron metabolism and iron deficiency in incident patients on incident continuous ambulatory peritoneal dialysis
- Tibial periosteum flap combined with autologous bone grafting in the treatment of Gustilo-IIIB/IIIC open tibial fractures
- The application of intravenous general anesthesia under nasopharyngeal airway assisted ventilation undergoing ureteroscopic holmium laser lithotripsy: A prospective, single-center, controlled trial
- Long intergenic noncoding RNA for IGF2BP2 stability suppresses gastric cancer cell apoptosis by inhibiting the maturation of microRNA-34a
- Role of FOXM1 and AURKB in regulating keratinocyte function in psoriasis
- Parental control attitudes over their pre-school children’s diet
- The role of auto-HSCT in extranodal natural killer/T cell lymphoma
- Significance of negative cervical cytology and positive HPV in the diagnosis of cervical lesions by colposcopy
- Echinacoside inhibits PASMCs calcium overload to prevent hypoxic pulmonary artery remodeling by regulating TRPC1/4/6 and calmodulin
- ADAR1 plays a protective role in proximal tubular cells under high glucose conditions by attenuating the PI3K/AKT/mTOR signaling pathway
- The risk of cancer among insulin glargine users in Lithuania: A retrospective population-based study
- The unusual location of primary hydatid cyst: A case series study
- Intraoperative changes in electrophysiological monitoring can be used to predict clinical outcomes in patients with spinal cavernous malformation
- Obesity and risk of placenta accreta spectrum: A meta-analysis
- Shikonin alleviates asthma phenotypes in mice via an airway epithelial STAT3-dependent mechanism
- NSUN6 and HTR7 disturbed the stability of carotid atherosclerotic plaques by regulating the immune responses of macrophages
- The effect of COVID-19 lockdown on admission rates in Maternity Hospital
- Temporal muscle thickness is not a prognostic predictor in patients with high-grade glioma, an experience at two centers in China
- Luteolin alleviates cerebral ischemia/reperfusion injury by regulating cell pyroptosis
- Therapeutic role of respiratory exercise in patients with tuberculous pleurisy
- Effects of CFTR-ENaC on spinal cord edema after spinal cord injury
- Irisin-regulated lncRNAs and their potential regulatory functions in chondrogenic differentiation of human mesenchymal stem cells
- DMD mutations in pediatric patients with phenotypes of Duchenne/Becker muscular dystrophy
- Combination of C-reactive protein and fibrinogen-to-albumin ratio as a novel predictor of all-cause mortality in heart failure patients
- Significant role and the underly mechanism of cullin-1 in chronic obstructive pulmonary disease
- Ferroptosis-related prognostic model of mantle cell lymphoma
- Observation of choking reaction and other related indexes in elderly painless fiberoptic bronchoscopy with transnasal high-flow humidification oxygen therapy
- A bibliometric analysis of Prader-Willi syndrome from 2002 to 2022
- The causal effects of childhood sunburn occasions on melanoma: A univariable and multivariable Mendelian randomization study
- Oxidative stress regulates glycogen synthase kinase-3 in lymphocytes of diabetes mellitus patients complicated with cerebral infarction
- Role of COX6C and NDUFB3 in septic shock and stroke
- Trends in disease burden of type 2 diabetes, stroke, and hypertensive heart disease attributable to high BMI in China: 1990–2019
- Purinergic P2X7 receptor mediates hyperoxia-induced injury in pulmonary microvascular endothelial cells via NLRP3-mediated pyroptotic pathway
- Investigating the role of oviductal mucosa–endometrial co-culture in modulating factors relevant to embryo implantation
- Analgesic effect of external oblique intercostal block in laparoscopic cholecystectomy: A retrospective study
- Elevated serum miR-142-5p correlates with ischemic lesions and both NSE and S100β in ischemic stroke patients
- Correlation between the mechanism of arteriopathy in IgA nephropathy and blood stasis syndrome: A cohort study
- Risk factors for progressive kyphosis after percutaneous kyphoplasty in osteoporotic vertebral compression fracture
- Predictive role of neuron-specific enolase and S100-β in early neurological deterioration and unfavorable prognosis in patients with ischemic stroke
- The potential risk factors of postoperative cognitive dysfunction for endovascular therapy in acute ischemic stroke with general anesthesia
- Fluoxetine inhibited RANKL-induced osteoclastic differentiation in vitro
- Detection of serum FOXM1 and IGF2 in patients with ARDS and their correlation with disease and prognosis
- Rhein promotes skin wound healing by activating the PI3K/AKT signaling pathway
- Differences in mortality risk by levels of physical activity among persons with disabilities in South Korea
- Review Articles
- Cutaneous signs of selected cardiovascular disorders: A narrative review
- XRCC1 and hOGG1 polymorphisms and endometrial carcinoma: A meta-analysis
- A narrative review on adverse drug reactions of COVID-19 treatments on the kidney
- Emerging role and function of SPDL1 in human health and diseases
- Adverse reactions of piperacillin: A literature review of case reports
- Molecular mechanism and intervention measures of microvascular complications in diabetes
- Regulation of mesenchymal stem cell differentiation by autophagy
- Molecular landscape of borderline ovarian tumours: A systematic review
- Advances in synthetic lethality modalities for glioblastoma multiforme
- Investigating hormesis, aging, and neurodegeneration: From bench to clinics
- Frankincense: A neuronutrient to approach Parkinson’s disease treatment
- Sox9: A potential regulator of cancer stem cells in osteosarcoma
- Early detection of cardiovascular risk markers through non-invasive ultrasound methodologies in periodontitis patients
- Advanced neuroimaging and criminal interrogation in lie detection
- Maternal factors for neural tube defects in offspring: An umbrella review
- The chemoprotective hormetic effects of rosmarinic acid
- CBD’s potential impact on Parkinson’s disease: An updated overview
- Progress in cytokine research for ARDS: A comprehensive review
- Utilizing reactive oxygen species-scavenging nanoparticles for targeting oxidative stress in the treatment of ischemic stroke: A review
- NRXN1-related disorders, attempt to better define clinical assessment
- Lidocaine infusion for the treatment of complex regional pain syndrome: Case series and literature review
- Trends and future directions of autophagy in osteosarcoma: A bibliometric analysis
- Iron in ventricular remodeling and aneurysms post-myocardial infarction
- Case Reports
- Sirolimus potentiated angioedema: A case report and review of the literature
- Identification of mixed anaerobic infections after inguinal hernia repair based on metagenomic next-generation sequencing: A case report
- Successful treatment with bortezomib in combination with dexamethasone in a middle-aged male with idiopathic multicentric Castleman’s disease: A case report
- Complete heart block associated with hepatitis A infection in a female child with fatal outcome
- Elevation of D-dimer in eosinophilic gastrointestinal diseases in the absence of venous thrombosis: A case series and literature review
- Four years of natural progressive course: A rare case report of juvenile Xp11.2 translocations renal cell carcinoma with TFE3 gene fusion
- Advancing prenatal diagnosis: Echocardiographic detection of Scimitar syndrome in China – A case series
- Outcomes and complications of hemodialysis in patients with renal cancer following bilateral nephrectomy
- Anti-HMGCR myopathy mimicking facioscapulohumeral muscular dystrophy
- Recurrent opportunistic infections in a HIV-negative patient with combined C6 and NFKB1 mutations: A case report, pedigree analysis, and literature review
- Letter to the Editor
- Letter to the Editor: Total parenteral nutrition-induced Wernicke’s encephalopathy after oncologic gastrointestinal surgery
- Erratum
- Erratum to “Bladder-embedded ectopic intrauterine device with calculus”
- Retraction
- Retraction of “XRCC1 and hOGG1 polymorphisms and endometrial carcinoma: A meta-analysis”
- Corrigendum
- Corrigendum to “Investigating hormesis, aging, and neurodegeneration: From bench to clinics”
- Corrigendum to “Frankincense: A neuronutrient to approach Parkinson’s disease treatment”
- Special Issue The evolving saga of RNAs from bench to bedside - Part II
- Machine-learning-based prediction of a diagnostic model using autophagy-related genes based on RNA sequencing for patients with papillary thyroid carcinoma
- Unlocking the future of hepatocellular carcinoma treatment: A comprehensive analysis of disulfidptosis-related lncRNAs for prognosis and drug screening
- Elevated mRNA level indicates FSIP1 promotes EMT and gastric cancer progression by regulating fibroblasts in tumor microenvironment
- Special Issue Advancements in oncology: bridging clinical and experimental research - Part I
- Ultrasound-guided transperineal vs transrectal prostate biopsy: A meta-analysis of diagnostic accuracy and complication rates
- Assessment of diagnostic value of unilateral systematic biopsy combined with targeted biopsy in detecting clinically significant prostate cancer
- SENP7 inhibits glioblastoma metastasis and invasion by dissociating SUMO2/3 binding to specific target proteins
- MARK1 suppress malignant progression of hepatocellular carcinoma and improves sorafenib resistance through negatively regulating POTEE
- Analysis of postoperative complications in bladder cancer patients
- Carboplatin combined with arsenic trioxide versus carboplatin combined with docetaxel treatment for LACC: A randomized, open-label, phase II clinical study
- Special Issue Exploring the biological mechanism of human diseases based on MultiOmics Technology - Part I
- Comprehensive pan-cancer investigation of carnosine dipeptidase 1 and its prospective prognostic significance in hepatocellular carcinoma
- Identification of signatures associated with microsatellite instability and immune characteristics to predict the prognostic risk of colon cancer
- Single-cell analysis identified key macrophage subpopulations associated with atherosclerosis
Articles in the same Issue
- Research Articles
- EDNRB inhibits the growth and migration of prostate cancer cells by activating the cGMP-PKG pathway
- STK11 (LKB1) mutation suppresses ferroptosis in lung adenocarcinoma by facilitating monounsaturated fatty acid synthesis
- Association of SOX6 gene polymorphisms with Kashin-Beck disease risk in the Chinese Han population
- The pyroptosis-related signature predicts prognosis and influences the tumor immune microenvironment in dedifferentiated liposarcoma
- METTL3 attenuates ferroptosis sensitivity in lung cancer via modulating TFRC
- Identification and validation of molecular subtypes and prognostic signature for stage I and stage II gastric cancer based on neutrophil extracellular traps
- Novel lumbar plexus block versus femoral nerve block for analgesia and motor recovery after total knee arthroplasty
- Correlation between ABCB1 and OLIG2 polymorphisms and the severity and prognosis of patients with cerebral infarction
- Study on the radiotherapy effect and serum neutral granulocyte lymphocyte ratio and inflammatory factor expression of nasopharyngeal carcinoma
- Transcriptome analysis of effects of Tecrl deficiency on cardiometabolic and calcium regulation in cardiac tissue
- Aflatoxin B1 induces infertility, fetal deformities, and potential therapies
- Serum levels of HMW adiponectin and its receptors are associated with cytokine levels and clinical characteristics in chronic obstructive pulmonary disease
- METTL3-mediated methylation of CYP2C19 mRNA may aggravate clopidogrel resistance in ischemic stroke patients
- Understand how machine learning impact lung cancer research from 2010 to 2021: A bibliometric analysis
- Pressure ulcers in German hospitals: Analysis of reimbursement and length of stay
- Metformin plus L-carnitine enhances brown/beige adipose tissue activity via Nrf2/HO-1 signaling to reduce lipid accumulation and inflammation in murine obesity
- Downregulation of carbonic anhydrase IX expression in mouse xenograft nasopharyngeal carcinoma model via doxorubicin nanobubble combined with ultrasound
- Feasibility of 3-dimensional printed models in simulated training and teaching of transcatheter aortic valve replacement
- miR-335-3p improves type II diabetes mellitus by IGF-1 regulating macrophage polarization
- The analyses of human MCPH1 DNA repair machinery and genetic variations
- Activation of Piezo1 increases the sensitivity of breast cancer to hyperthermia therapy
- Comprehensive analysis based on the disulfidptosis-related genes identifies hub genes and immune infiltration for pancreatic adenocarcinoma
- Changes of serum CA125 and PGE2 before and after high-intensity focused ultrasound combined with GnRH-a in treatment of patients with adenomyosis
- The clinical value of the hepatic venous pressure gradient in patients undergoing hepatic resection for hepatocellular carcinoma with or without liver cirrhosis
- Development and validation of a novel model to predict pulmonary embolism in cardiology suspected patients: A 10-year retrospective analysis
- Downregulation of lncRNA XLOC_032768 in diabetic patients predicts the occurrence of diabetic nephropathy
- Circ_0051428 targeting miR-885-3p/MMP2 axis enhances the malignancy of cervical cancer
- Effectiveness of ginkgo diterpene lactone meglumine on cognitive function in patients with acute ischemic stroke
- The construction of a novel prognostic prediction model for glioma based on GWAS-identified prognostic-related risk loci
- Evaluating the impact of childhood BMI on the risk of coronavirus disease 2019: A Mendelian randomization study
- Lactate dehydrogenase to albumin ratio is associated with in-hospital mortality in patients with acute heart failure: Data from the MIMIC-III database
- CD36-mediated podocyte lipotoxicity promotes foot process effacement
- Efficacy of etonogestrel subcutaneous implants versus the levonorgestrel-releasing intrauterine system in the conservative treatment of adenomyosis
- FLRT2 mediates chondrogenesis of nasal septal cartilage and mandibular condyle cartilage
- Challenges in treating primary immune thrombocytopenia patients undergoing COVID-19 vaccination: A retrospective study
- Let-7 family regulates HaCaT cell proliferation and apoptosis via the ΔNp63/PI3K/AKT pathway
- Phospholipid transfer protein ameliorates sepsis-induced cardiac dysfunction through NLRP3 inflammasome inhibition
- Postoperative cognitive dysfunction in elderly patients with colorectal cancer: A randomized controlled study comparing goal-directed and conventional fluid therapy
- Long-pulsed ultrasound-mediated microbubble thrombolysis in a rat model of microvascular obstruction
- High SEC61A1 expression predicts poor outcome of acute myeloid leukemia
- Comparison of polymerase chain reaction and next-generation sequencing with conventional urine culture for the diagnosis of urinary tract infections: A meta-analysis
- Secreted frizzled-related protein 5 protects against renal fibrosis by inhibiting Wnt/β-catenin pathway
- Pan-cancer and single-cell analysis of actin cytoskeleton genes related to disulfidptosis
- Overexpression of miR-532-5p restrains oxidative stress response of chondrocytes in nontraumatic osteonecrosis of the femoral head by inhibiting ABL1
- Autologous liver transplantation for unresectable hepatobiliary malignancies in enhanced recovery after surgery model
- Clinical analysis of incomplete rupture of the uterus secondary to previous cesarean section
- Abnormal sleep duration is associated with sarcopenia in older Chinese people: A large retrospective cross-sectional study
- No genetic causality between obesity and benign paroxysmal vertigo: A two-sample Mendelian randomization study
- Identification and validation of autophagy-related genes in SSc
- Long non-coding RNA SRA1 suppresses radiotherapy resistance in esophageal squamous cell carcinoma by modulating glycolytic reprogramming
- Evaluation of quality of life in patients with schizophrenia: An inpatient social welfare institution-based cross-sectional study
- The possible role of oxidative stress marker glutathione in the assessment of cognitive impairment in multiple sclerosis
- Compilation of a self-management assessment scale for postoperative patients with aortic dissection
- Left atrial appendage closure in conjunction with radiofrequency ablation: Effects on left atrial functioning in patients with paroxysmal atrial fibrillation
- Effect of anterior femoral cortical notch grade on postoperative function and complications during TKA surgery: A multicenter, retrospective study
- Clinical characteristics and assessment of risk factors in patients with influenza A-induced severe pneumonia after the prevalence of SARS-CoV-2
- Analgesia nociception index is an indicator of laparoscopic trocar insertion-induced transient nociceptive stimuli
- High STAT4 expression correlates with poor prognosis in acute myeloid leukemia and facilitates disease progression by upregulating VEGFA expression
- Factors influencing cardiovascular system-related post-COVID-19 sequelae: A single-center cohort study
- HOXD10 regulates intestinal permeability and inhibits inflammation of dextran sulfate sodium-induced ulcerative colitis through the inactivation of the Rho/ROCK/MMPs axis
- Mesenchymal stem cell-derived exosomal miR-26a induces ferroptosis, suppresses hepatic stellate cell activation, and ameliorates liver fibrosis by modulating SLC7A11
- Endovascular thrombectomy versus intravenous thrombolysis for primary distal, medium vessel occlusion in acute ischemic stroke
- ANO6 (TMEM16F) inhibits gastrointestinal stromal tumor growth and induces ferroptosis
- Prognostic value of EIF5A2 in solid tumors: A meta-analysis and bioinformatics analysis
- The role of enhanced expression of Cx43 in patients with ulcerative colitis
- Choosing a COVID-19 vaccination site might be driven by anxiety and body vigilance
- Role of ICAM-1 in triple-negative breast cancer
- Cost-effectiveness of ambroxol in the treatment of Gaucher disease type 2
- HLA-DRB5 promotes immune thrombocytopenia via activating CD8+ T cells
- Efficacy and factors of myofascial release therapy combined with electrical and magnetic stimulation in the treatment of chronic pelvic pain syndrome
- Efficacy of tacrolimus monotherapy in primary membranous nephropathy
- Mechanisms of Tripterygium wilfordii Hook F on treating rheumatoid arthritis explored by network pharmacology analysis and molecular docking
- FBXO45 levels regulated ferroptosis renal tubular epithelial cells in a model of diabetic nephropathy by PLK1
- Optimizing anesthesia strategies to NSCLC patients in VATS procedures: Insights from drug requirements and patient recovery patterns
- Alpha-lipoic acid upregulates the PPARγ/NRF2/GPX4 signal pathway to inhibit ferroptosis in the pathogenesis of unexplained recurrent pregnancy loss
- Correlation between fat-soluble vitamin levels and inflammatory factors in paediatric community-acquired pneumonia: A prospective study
- CD1d affects the proliferation, migration, and apoptosis of human papillary thyroid carcinoma TPC-1 cells via regulating MAPK/NF-κB signaling pathway
- miR-let-7a inhibits sympathetic nerve remodeling after myocardial infarction by downregulating the expression of nerve growth factor
- Immune response analysis of solid organ transplantation recipients inoculated with inactivated COVID-19 vaccine: A retrospective analysis
- The H2Valdien derivatives regulate the epithelial–mesenchymal transition of hepatoma carcinoma cells through the Hedgehog signaling pathway
- Clinical efficacy of dexamethasone combined with isoniazid in the treatment of tuberculous meningitis and its effect on peripheral blood T cell subsets
- Comparison of short-segment and long-segment fixation in treatment of degenerative scoliosis and analysis of factors associated with adjacent spondylolisthesis
- Lycopene inhibits pyroptosis of endothelial progenitor cells induced by ox-LDL through the AMPK/mTOR/NLRP3 pathway
- Methylation regulation for FUNDC1 stability in childhood leukemia was up-regulated and facilitates metastasis and reduces ferroptosis of leukemia through mitochondrial damage by FBXL2
- Correlation of single-fiber electromyography studies and functional status in patients with amyotrophic lateral sclerosis
- Risk factors of postoperative airway obstruction complications in children with oral floor mass
- Expression levels and clinical significance of serum miR-19a/CCL20 in patients with acute cerebral infarction
- Physical activity and mental health trends in Korean adolescents: Analyzing the impact of the COVID-19 pandemic from 2018 to 2022
- Evaluating anemia in HIV-infected patients using chest CT
- Ponticulus posticus and skeletal malocclusion: A pilot study in a Southern Italian pre-orthodontic court
- Causal association of circulating immune cells and lymphoma: A Mendelian randomization study
- Assessment of the renal function and fibrosis indexes of conventional western medicine with Chinese medicine for dredging collaterals on treating renal fibrosis: A systematic review and meta-analysis
- Comprehensive landscape of integrator complex subunits and their association with prognosis and tumor microenvironment in gastric cancer
- New target-HMGCR inhibitors for the treatment of primary sclerosing cholangitis: A drug Mendelian randomization study
- Population pharmacokinetics of meropenem in critically ill patients
- Comparison of the ability of newly inflammatory markers to predict complicated appendicitis
- Comparative morphology of the cruciate ligaments: A radiological study
- Immune landscape of hepatocellular carcinoma: The central role of TP53-inducible glycolysis and apoptosis regulator
- Serum SIRT3 levels in epilepsy patients and its association with clinical outcomes and severity: A prospective observational study
- SHP-1 mediates cigarette smoke extract-induced epithelial–mesenchymal transformation and inflammation in 16HBE cells
- Acute hyper-hypoxia accelerates the development of depression in mice via the IL-6/PGC1α/MFN2 signaling pathway
- The GJB3 correlates with the prognosis, immune cell infiltration, and therapeutic responses in lung adenocarcinoma
- Physical fitness and blood parameters outcomes of breast cancer survivor in a low-intensity circuit resistance exercise program
- Exploring anesthetic-induced gene expression changes and immune cell dynamics in atrial tissue post-coronary artery bypass graft surgery
- Empagliflozin improves aortic injury in obese mice by regulating fatty acid metabolism
- Analysis of the risk factors of the radiation-induced encephalopathy in nasopharyngeal carcinoma: A retrospective cohort study
- Reproductive outcomes in women with BRCA 1/2 germline mutations: A retrospective observational study and literature review
- Evaluation of upper airway ultrasonographic measurements in predicting difficult intubation: A cross-section of the Turkish population
- Prognostic and diagnostic value of circulating IGFBP2 in pancreatic cancer
- Postural stability after operative reconstruction of the AFTL in chronic ankle instability comparing three different surgical techniques
- Research trends related to emergence agitation in the post-anaesthesia care unit from 2001 to 2023: A bibliometric analysis
- Frequency and clinicopathological correlation of gastrointestinal polyps: A six-year single center experience
- ACSL4 mediates inflammatory bowel disease and contributes to LPS-induced intestinal epithelial cell dysfunction by activating ferroptosis and inflammation
- Affibody-based molecular probe 99mTc-(HE)3ZHER2:V2 for non-invasive HER2 detection in ovarian and breast cancer xenografts
- Effectiveness of nutritional support for clinical outcomes in gastric cancer patients: A meta-analysis of randomized controlled trials
- The relationship between IFN-γ, IL-10, IL-6 cytokines, and severity of the condition with serum zinc and Fe in children infected with Mycoplasma pneumoniae
- Paraquat disrupts the blood–brain barrier by increasing IL-6 expression and oxidative stress through the activation of PI3K/AKT signaling pathway
- Sleep quality associate with the increased prevalence of cognitive impairment in coronary artery disease patients: A retrospective case–control study
- Dioscin protects against chronic prostatitis through the TLR4/NF-κB pathway
- Association of polymorphisms in FBN1, MYH11, and TGF-β signaling-related genes with susceptibility of sporadic thoracic aortic aneurysm and dissection in the Zhejiang Han population
- Application value of multi-parameter magnetic resonance image-transrectal ultrasound cognitive fusion in prostate biopsy
- Laboratory variables‐based artificial neural network models for predicting fatty liver disease: A retrospective study
- Decreased BIRC5-206 promotes epithelial–mesenchymal transition in nasopharyngeal carcinoma through sponging miR-145-5p
- Sepsis induces the cardiomyocyte apoptosis and cardiac dysfunction through activation of YAP1/Serpine1/caspase-3 pathway
- Assessment of iron metabolism and iron deficiency in incident patients on incident continuous ambulatory peritoneal dialysis
- Tibial periosteum flap combined with autologous bone grafting in the treatment of Gustilo-IIIB/IIIC open tibial fractures
- The application of intravenous general anesthesia under nasopharyngeal airway assisted ventilation undergoing ureteroscopic holmium laser lithotripsy: A prospective, single-center, controlled trial
- Long intergenic noncoding RNA for IGF2BP2 stability suppresses gastric cancer cell apoptosis by inhibiting the maturation of microRNA-34a
- Role of FOXM1 and AURKB in regulating keratinocyte function in psoriasis
- Parental control attitudes over their pre-school children’s diet
- The role of auto-HSCT in extranodal natural killer/T cell lymphoma
- Significance of negative cervical cytology and positive HPV in the diagnosis of cervical lesions by colposcopy
- Echinacoside inhibits PASMCs calcium overload to prevent hypoxic pulmonary artery remodeling by regulating TRPC1/4/6 and calmodulin
- ADAR1 plays a protective role in proximal tubular cells under high glucose conditions by attenuating the PI3K/AKT/mTOR signaling pathway
- The risk of cancer among insulin glargine users in Lithuania: A retrospective population-based study
- The unusual location of primary hydatid cyst: A case series study
- Intraoperative changes in electrophysiological monitoring can be used to predict clinical outcomes in patients with spinal cavernous malformation
- Obesity and risk of placenta accreta spectrum: A meta-analysis
- Shikonin alleviates asthma phenotypes in mice via an airway epithelial STAT3-dependent mechanism
- NSUN6 and HTR7 disturbed the stability of carotid atherosclerotic plaques by regulating the immune responses of macrophages
- The effect of COVID-19 lockdown on admission rates in Maternity Hospital
- Temporal muscle thickness is not a prognostic predictor in patients with high-grade glioma, an experience at two centers in China
- Luteolin alleviates cerebral ischemia/reperfusion injury by regulating cell pyroptosis
- Therapeutic role of respiratory exercise in patients with tuberculous pleurisy
- Effects of CFTR-ENaC on spinal cord edema after spinal cord injury
- Irisin-regulated lncRNAs and their potential regulatory functions in chondrogenic differentiation of human mesenchymal stem cells
- DMD mutations in pediatric patients with phenotypes of Duchenne/Becker muscular dystrophy
- Combination of C-reactive protein and fibrinogen-to-albumin ratio as a novel predictor of all-cause mortality in heart failure patients
- Significant role and the underly mechanism of cullin-1 in chronic obstructive pulmonary disease
- Ferroptosis-related prognostic model of mantle cell lymphoma
- Observation of choking reaction and other related indexes in elderly painless fiberoptic bronchoscopy with transnasal high-flow humidification oxygen therapy
- A bibliometric analysis of Prader-Willi syndrome from 2002 to 2022
- The causal effects of childhood sunburn occasions on melanoma: A univariable and multivariable Mendelian randomization study
- Oxidative stress regulates glycogen synthase kinase-3 in lymphocytes of diabetes mellitus patients complicated with cerebral infarction
- Role of COX6C and NDUFB3 in septic shock and stroke
- Trends in disease burden of type 2 diabetes, stroke, and hypertensive heart disease attributable to high BMI in China: 1990–2019
- Purinergic P2X7 receptor mediates hyperoxia-induced injury in pulmonary microvascular endothelial cells via NLRP3-mediated pyroptotic pathway
- Investigating the role of oviductal mucosa–endometrial co-culture in modulating factors relevant to embryo implantation
- Analgesic effect of external oblique intercostal block in laparoscopic cholecystectomy: A retrospective study
- Elevated serum miR-142-5p correlates with ischemic lesions and both NSE and S100β in ischemic stroke patients
- Correlation between the mechanism of arteriopathy in IgA nephropathy and blood stasis syndrome: A cohort study
- Risk factors for progressive kyphosis after percutaneous kyphoplasty in osteoporotic vertebral compression fracture
- Predictive role of neuron-specific enolase and S100-β in early neurological deterioration and unfavorable prognosis in patients with ischemic stroke
- The potential risk factors of postoperative cognitive dysfunction for endovascular therapy in acute ischemic stroke with general anesthesia
- Fluoxetine inhibited RANKL-induced osteoclastic differentiation in vitro
- Detection of serum FOXM1 and IGF2 in patients with ARDS and their correlation with disease and prognosis
- Rhein promotes skin wound healing by activating the PI3K/AKT signaling pathway
- Differences in mortality risk by levels of physical activity among persons with disabilities in South Korea
- Review Articles
- Cutaneous signs of selected cardiovascular disorders: A narrative review
- XRCC1 and hOGG1 polymorphisms and endometrial carcinoma: A meta-analysis
- A narrative review on adverse drug reactions of COVID-19 treatments on the kidney
- Emerging role and function of SPDL1 in human health and diseases
- Adverse reactions of piperacillin: A literature review of case reports
- Molecular mechanism and intervention measures of microvascular complications in diabetes
- Regulation of mesenchymal stem cell differentiation by autophagy
- Molecular landscape of borderline ovarian tumours: A systematic review
- Advances in synthetic lethality modalities for glioblastoma multiforme
- Investigating hormesis, aging, and neurodegeneration: From bench to clinics
- Frankincense: A neuronutrient to approach Parkinson’s disease treatment
- Sox9: A potential regulator of cancer stem cells in osteosarcoma
- Early detection of cardiovascular risk markers through non-invasive ultrasound methodologies in periodontitis patients
- Advanced neuroimaging and criminal interrogation in lie detection
- Maternal factors for neural tube defects in offspring: An umbrella review
- The chemoprotective hormetic effects of rosmarinic acid
- CBD’s potential impact on Parkinson’s disease: An updated overview
- Progress in cytokine research for ARDS: A comprehensive review
- Utilizing reactive oxygen species-scavenging nanoparticles for targeting oxidative stress in the treatment of ischemic stroke: A review
- NRXN1-related disorders, attempt to better define clinical assessment
- Lidocaine infusion for the treatment of complex regional pain syndrome: Case series and literature review
- Trends and future directions of autophagy in osteosarcoma: A bibliometric analysis
- Iron in ventricular remodeling and aneurysms post-myocardial infarction
- Case Reports
- Sirolimus potentiated angioedema: A case report and review of the literature
- Identification of mixed anaerobic infections after inguinal hernia repair based on metagenomic next-generation sequencing: A case report
- Successful treatment with bortezomib in combination with dexamethasone in a middle-aged male with idiopathic multicentric Castleman’s disease: A case report
- Complete heart block associated with hepatitis A infection in a female child with fatal outcome
- Elevation of D-dimer in eosinophilic gastrointestinal diseases in the absence of venous thrombosis: A case series and literature review
- Four years of natural progressive course: A rare case report of juvenile Xp11.2 translocations renal cell carcinoma with TFE3 gene fusion
- Advancing prenatal diagnosis: Echocardiographic detection of Scimitar syndrome in China – A case series
- Outcomes and complications of hemodialysis in patients with renal cancer following bilateral nephrectomy
- Anti-HMGCR myopathy mimicking facioscapulohumeral muscular dystrophy
- Recurrent opportunistic infections in a HIV-negative patient with combined C6 and NFKB1 mutations: A case report, pedigree analysis, and literature review
- Letter to the Editor
- Letter to the Editor: Total parenteral nutrition-induced Wernicke’s encephalopathy after oncologic gastrointestinal surgery
- Erratum
- Erratum to “Bladder-embedded ectopic intrauterine device with calculus”
- Retraction
- Retraction of “XRCC1 and hOGG1 polymorphisms and endometrial carcinoma: A meta-analysis”
- Corrigendum
- Corrigendum to “Investigating hormesis, aging, and neurodegeneration: From bench to clinics”
- Corrigendum to “Frankincense: A neuronutrient to approach Parkinson’s disease treatment”
- Special Issue The evolving saga of RNAs from bench to bedside - Part II
- Machine-learning-based prediction of a diagnostic model using autophagy-related genes based on RNA sequencing for patients with papillary thyroid carcinoma
- Unlocking the future of hepatocellular carcinoma treatment: A comprehensive analysis of disulfidptosis-related lncRNAs for prognosis and drug screening
- Elevated mRNA level indicates FSIP1 promotes EMT and gastric cancer progression by regulating fibroblasts in tumor microenvironment
- Special Issue Advancements in oncology: bridging clinical and experimental research - Part I
- Ultrasound-guided transperineal vs transrectal prostate biopsy: A meta-analysis of diagnostic accuracy and complication rates
- Assessment of diagnostic value of unilateral systematic biopsy combined with targeted biopsy in detecting clinically significant prostate cancer
- SENP7 inhibits glioblastoma metastasis and invasion by dissociating SUMO2/3 binding to specific target proteins
- MARK1 suppress malignant progression of hepatocellular carcinoma and improves sorafenib resistance through negatively regulating POTEE
- Analysis of postoperative complications in bladder cancer patients
- Carboplatin combined with arsenic trioxide versus carboplatin combined with docetaxel treatment for LACC: A randomized, open-label, phase II clinical study
- Special Issue Exploring the biological mechanism of human diseases based on MultiOmics Technology - Part I
- Comprehensive pan-cancer investigation of carnosine dipeptidase 1 and its prospective prognostic significance in hepatocellular carcinoma
- Identification of signatures associated with microsatellite instability and immune characteristics to predict the prognostic risk of colon cancer
- Single-cell analysis identified key macrophage subpopulations associated with atherosclerosis