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Abstract

Enterovirus (EV)-C105 is a rare genotype not previously detected in Spain. Between 2019 and 2024, we detected EV-C105 in respiratory samples of five patients, through routine EV surveillance. Three cases had respiratory illness and two were hospitalised for neurological illness. Four of the five sequenced strains belonged to an emerging clade (C1), defined by four novel nonsynonymous mutations in key antigenic epitopes. We recommend reinforced clinical awareness and EV genomic surveillance, including respiratory samples, even when symptoms are neurological.

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/content/10.2807/1560-7917.ES.2025.30.6.2500073
2025-02-13
2025-07-14
/content/10.2807/1560-7917.ES.2025.30.6.2500073
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Detections of rare enterovirus C105 linked to an emerging novel clade, Spain, 2019 to 2024
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Maria+Dolores+Fernandez-Garcia&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Fernandez-Garcia Maria Dolores</a>, <a href="/search?value1=Juan+Camacho&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Camacho Juan</a>, <a href="/search?value1=Francisco+Diez-Fuertes&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Diez-Fuertes Francisco</a>, <a href="/search?value1=Estrella+Ruiz+de+Pedro&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ruiz de Pedro Estrella</a>, <a href="/search?value1=Nerea+Garc%C3%ADa-Iba%C3%B1ez&option1=author&noRedirect=true" class="nonDisambigAuthorLink">García-Ibañez Nerea</a>, <a href="/search?value1=Ana+Navascu%C3%A9s&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Navascués Ana</a>, <a href="/search?value1=Carla+Berengua&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Berengua Carla</a>, <a href="/search?value1=Pedro+Antequera-Rodriguez&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Antequera-Rodriguez Pedro</a>, <a href="/search?value1=Montserrat+Ruiz-Garc%C3%ADa&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ruiz-García Montserrat</a>, <a href="/search?value1=Maria+Teresa+Pastor-Fajardo&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pastor-Fajardo Maria Teresa</a>, <a href="/search?value1=Mar%C3%ADa+Cabrerizo&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Cabrerizo María</a></span>. Detections of rare enterovirus C105 linked to an emerging novel clade, Spain, 2019 to 2024. <a href="/content/ecdc">Euro Surveill.</a> 2025;30(6):pii=2500073. <a href="https://doi.org/10.2807/1560-7917.ES.2025.30.6.2500073" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2025.30.6.2500073</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 24 Jan 2025;&nbsp;&nbsp; <span class="generated">Accepted</span>: 13 Feb 2025 </span> </p>
/content/10.2807/1560-7917.ES.2025.30.6.2500073
/content/10.2807/1560-7917.ES.2025.30.6.2500073
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