IMR Press / AP / Volume 26 / Issue 1 / DOI: 10.31083/AP38792
Open Access Original Article
Trends in Benzodiazepine and Z-Drug Prescriptions in Eastern China (2015–2021)
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Affiliation
1 Department of Pharmacy, The Seventh People’s Hospital of Shaoxing, 312000 Shaoxing, Zhejiang, China
*Correspondence: chenhualing0055@163.com (Hualiang Chen)
Alpha Psychiatry 2025, 26(1), 38792; https://doi.org/10.31083/AP38792
Submitted: 22 May 2024 | Revised: 2 August 2024 | Accepted: 19 August 2024 | Published: 28 February 2025
Copyright: © 2025 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.
Abstract
Objective:

This study analyses trends in the prescription and usage of benzodiazepines (BZDs) and Z-drugs within specialised medical institutions and emergency outpatient services in China from 2015 to 2021, focusing on demographics and prescribing patterns to promote better management practices.

Methods:

A retrospective study was conducted from 2015 to 2021, reviewing prescription information and population characteristics from 10 hospitals, including specialised psychiatric institutions and general hospitals in Zhejiang, Jiangsu, and Shanghai. The study analysed a total of 33,569 valid prescriptions.

Results:

There was a noticeable increase in the total defined daily doses of both benzodiazepines and Z-drugs, with significant variations among different drugs. Lorazepam and zopiclone showed the most substantial increases in usage. Drugs like clonazepam and lorazepam were predominantly prescribed, indicating specific patterns in disease management, particularly for insomnia and anxiety.

Conclusions:

This study reveals a significant increase in benzodiazepine and Z-drug prescriptions, particularly among elderly and female patients. The findings highlight the need for targeted interventions and policy reforms to ensure safe prescribing practices and mitigate the risks associated with long-term use in these vulnerable populations.

Keywords
benzodiazepines
Z-drugs
outpatient and emergency prescriptions
trend analysis
Figures
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