Chronic Central Nervous System Graft-Versus-Host Disease to Unravel Progressive Visual Loss and Ischemic Stroke Recurrence Post-Allogeneic Hematopoietic Stem Cell Transplant: A Case Report
Abstract
:1. Introduction
2. Case Presentation
3. Discussion
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Abbreviations
AML | Acute myeloid leukemia |
CNS | Central nervous system |
CSF | Cerebrospinal fluid |
HLA | Human Leukocyte Antigen |
CMV | Cytomegalovirus |
FLAIR | Fluid-attenuated inversion recovery |
GVHD | Graft-versus-host disease |
HSCT | Hematopoietic stem cell transplant |
LAC | Lupus anticoagulant |
TMA | Thrombotic microangiopathy |
MRI | Magnetic resonance imaging |
OCB | Oligoclonal bands |
VEP | Visual evoked potentials |
References
- Grauer, O.; Wolff, D.; Bertz, H.; Greinix, H.; Kühl, J.S.; Lawitschka, A.; Lee, S.J.; Pavletic, S.Z.; Ernst Holler Kleiter, I. Neurological manifestations of chronic graft-versus-host disease after allogeneic haematopoietic stem cell transplantation: Report from the Consensus Conference on Clinical Practice in chronic graft-versus-host disease. Brain J. Neurol. 2010, 133, 2852–2865. [Google Scholar] [CrossRef] [PubMed]
- Wieczorek, M.; Mariotto, S.; Ferrari, S.; Mosna, F.; Micò, M.C.; Borghero, C.; Dubbini, M.V.; Malagola, M.; Skert, C.; Andreini, A.; et al. Neurological complications in adult allogeneic hematopoietic stem cell transplant patients: Incidence, characteristics and long-term follow-up in a multicenter series. Bone Marrow Transpl. 2022, 57, 1133–1141. [Google Scholar] [CrossRef] [PubMed]
- Gavriilaki, M.; Mainou, M.; Gavriilaki, E.; Haidich, A.B.; Papagiannopoulos, S.; Sakellari, I.; Anagnostopoulos, A.; Kimiskidis, V. Neurologic complications after allogeneic transplantation: A meta-analysis. Ann. Clin. Transl. Neurol. 2019, 6, 2037–2047. [Google Scholar] [CrossRef]
- Ferrara, J.L.; Levine, J.E.; Reddy, P.; Holler, E. Graft-versus-host disease. Lancet 2009, 373, 1550–1561. [Google Scholar] [CrossRef]
- Cuvelier, G.D.; Schoettler, M.; Buxbaum, N.P.; Pinal-Fernandez, I.; Schmalzing, M.; Distler, J.H.; Penack, O.; Santomasso, B.D.; Zeiser, R.; Angstwurm, K.; et al. Toward a Better Understanding of the 10 Atypical Features of Chronic Graft-Versus-Host Disease: A Report from the 2020 National 11 Institutes of Health Consensus Project Task Force. Transpl. Cell Ther. 2022, 28, 426–445. [Google Scholar] [CrossRef]
- Openshaw, H.; Vogelsang, G.B.; Pavletic, S.Z. Neurological Manifestations of Chronic Graft Versus Host Disease, Chronic Graft Versus Host Disease; Cambridge University Press: New York, NY, USA, 2009; pp. 243–251. [Google Scholar]
- Siegal, D.; Keller, A.; Xu, W.; Bhuta, S.; Kim, D.H.; Kuruvilla, J.; Lipton, J.H.; Messner, H.; Gupta, V. Central nervous system complications after allogeneic hematopoietic stem cell transplantation: Incidence, manifestations, and clinical significance. Biol. Blood Marrow Transpl. 2007, 13, 1369–1379. [Google Scholar] [CrossRef]
- Lambert, N.; Forte, F.; El Moussaoui, M.; Monseur, J.; Raus, N.; Polushin, A.; Michonneau, D.; Shultz, C.; Hogan, W.J.; Balaguer-Roselló, A.; et al. Central nervous system manifestations in acute and chronic graft-versus-host disease. Brain 2024, awae340. [Google Scholar] [CrossRef] [PubMed]
- Padovan, C.S.; Bise, K.; Hahn, J.; Sostak, P.; Holler, E.; Kolb, H.J.; Straube, A. Angiitis of the central nervous system after allogeneic bone marrow transplantation? Stroke 1999, 30, 1651–1656. [Google Scholar] [CrossRef]
- Ruggiu, M.; Cuccuini, W.; Mokhtari, K.; Meignin, V.; Peffault de Latour, R.; Robin, M.; Fontbrune, F.S.; Xhaard, A.; Socié, G.; Michonneau, D. Case report: Central nervous system involvement of human graft versus host disease: Report of 7 cases and a review of literature. Medicine 2017, 96, e8303. [Google Scholar] [CrossRef]
- Wang, X.; Billick, M.; Monsour, D.; Liu, J. Central nervous system graft-versus-host disease in a 68-year-old man presenting with myoclonus. CMAJ 2019, 191, E1078–E1081. [Google Scholar] [CrossRef]
- Ma, M.; Barnes, G.; Pulliam, J.; Jezek, D.; Baumann, R.J.; Berger, J.R. CNS angiitis in graft vs. host disease. Neurology 2002, 59, 1994–1997. [Google Scholar] [CrossRef] [PubMed]
- Campbell, J.N.; Morris, P.P. Cerebral vasculitis in graft-versus-host disease: A case report. AJNR Am. J. Neuroradiol. 2005, 26, 654–656. [Google Scholar]
- Sakellari, I.; Gavriilaki, E.; Papagiannopoulos, S.; Gavriilaki, M.; Batsis, I.; Mallouri, D.; Vardi, A.; Constantinou, V.; Masmanidou, M.; Yannaki, E.; et al. Neurological adverse events post allogeneic hematopoietic cell transplantation: Major determinants of morbidity and mortality. J. Neurol. 2019, 266, 1960–1972. [Google Scholar] [CrossRef] [PubMed]
- Coplin, W.M.; Cochran, M.S.; Levine, S.R.; Crawford, S.W. Stroke after bone marrow transplantation: Frequency, aetiology and outcome. Brain 2001, 124 Pt 5, 1043–1051. [Google Scholar] [CrossRef] [PubMed]
- Wang, B.; Jiang, F.; Wang, X. Optic neuropathy associated with GVHD after bone marrow allogeneic hematopoietic stem cell transplantation for B-Acute lymphoblastic leukemia: Case report. BMC Ophthalmol. 2022, 22, 97. [Google Scholar] [CrossRef] [PubMed]
- Khalili, M.R.; Bremner, F.; Tabrizi, R.; Bashi, A. Optical coherence tomography angiography (OCT angiography) in anterior ischemic optic neuropathy (AION): A systematic review and meta-analysis. Eur. J. Ophthalmol. 2023, 33, 530–545. [Google Scholar] [CrossRef] [PubMed]
- Yin, D.; de Groot, P.G.; Ninivaggi, M.; Devreese, K.M.J.; de Laat, B. Clinical Relevance of Isolated Lupus Anticoagulant Positivity in Patients with Thrombotic Antiphospholipid Syndrome. Thromb. Haemost. 2021, 121, 1220–1227. [Google Scholar] [CrossRef] [PubMed]
- Miyakis, S.; Lockshin, M.D.; Atsumi, T.; Branch, D.W.; Brey, R.L.; Cervera, R.; Derksen, R.H.; DEGroot, P.G.; Koike, T.; Meroni, P.L.; et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J. Thromb. Haemost. 2006, 4, 295–306. [Google Scholar] [CrossRef] [PubMed]
- Ljungman, P.; Brand, R.; Hoek, J.; de la Camara, R.; Cordonnier, C.; Einsele, H.; Styczynski, J.; Ward, K.N.; Cesaro, S. Donor cytomegalovirus status influences the outcome of allogeneic stem cell transplant: A study by the European group for blood and marrow transplantation. Clin. Infect. Dis. 2014, 59, 473–481. [Google Scholar] [CrossRef] [PubMed]
- Ljungman, P.; Brand, R.; Einsele, H.; Frassoni, F.; Niederwieser, D.; Cordonnier, C. Donor CMV serologic status and outcome of CMV-seropositive recipients after unrelated donor stem cell transplantation: An EBMT megafile analysis. Blood 2003, 102, 4255–4260. [Google Scholar] [CrossRef] [PubMed]
- Jacobsen, N.; Andersen, H.K.; Skinhøj, P.; Ryder, L.P.; Platz, P.; Jerne, D.; Faber, V. Correlation between donor cytomegalovirus immunity and chronic graft-versus-host disease after allogeneic bone marrow transplantation. Scand. J. Haematol. 1986, 36, 499–506. [Google Scholar] [CrossRef]
- Atkinson, K.; Biggs, J.; Darveniza, P.; Boland, J.; Concannon, A.; Dodds, A. Cyclosporin-associated central nervous system toxicity after allogeneic bone marrow transplantation. Transplantation 1984, 38, 34–37. [Google Scholar] [CrossRef] [PubMed]
- Özütemiz, C.; Roshan, S.K.; Kroll, N.J.; Benson, J.C.; Rykken, J.B.; Oswood, M.C.; Zhang, L.; McKinney, A.M. Acute Toxic Leukoencephalopathy: Etiologies, Imaging Findings, and Outcomes in 101 Patients. AJNR Am. J. Neuroradiol. 2019, 40, 267–275. [Google Scholar] [CrossRef] [PubMed]
- Johnston, D.L.; Alonzo, T.A.; Gerbing, R.B.; Aplenc, R.; Woods, W.G.; Meshinchi, S.; Gamis, A.S. Central nervous system disease in pediatric acute myeloid leukemia: A report from the Children’s Oncology Group. Pediatr. Blood Cancer 2017, 64, e26612. [Google Scholar] [CrossRef]
- Alakel, N.; Stölzel, F.; Mohr, B.; Kramer, M.; Oelschlägel, U.; Röllig, C.; Bornhäuser, M.; Ehninger, G.; Schaich, M. Symptomatic central nervous system involvement in adult patients with acute myeloid leukemia. Cancer Manag. Res. 2017, 9, 97–102. [Google Scholar] [CrossRef] [PubMed]
- Deak, D.; Gorcea-Andronic, N.; Sas, V.; Teodorescu, P.; Constantinescu, C.; Iluta, S.; Pasca, S.; Hotea, I.; Turcas, C.; Moisoiu, V.; et al. A narrative review of central nervous system involvement in acute leukemias. Ann. Transl. Med. 2021, 9, 68. [Google Scholar] [CrossRef]
Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content. |
© 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Share and Cite
Crescenzo, F.; Danese, A.; Dall’Ora, F.; Turazzini, M. Chronic Central Nervous System Graft-Versus-Host Disease to Unravel Progressive Visual Loss and Ischemic Stroke Recurrence Post-Allogeneic Hematopoietic Stem Cell Transplant: A Case Report. Int. J. Mol. Sci. 2025, 26, 2289. https://doi.org/10.3390/ijms26052289
Crescenzo F, Danese A, Dall’Ora F, Turazzini M. Chronic Central Nervous System Graft-Versus-Host Disease to Unravel Progressive Visual Loss and Ischemic Stroke Recurrence Post-Allogeneic Hematopoietic Stem Cell Transplant: A Case Report. International Journal of Molecular Sciences. 2025; 26(5):2289. https://doi.org/10.3390/ijms26052289
Chicago/Turabian StyleCrescenzo, Francesco, Alessandra Danese, Francesco Dall’Ora, and Michelangelo Turazzini. 2025. "Chronic Central Nervous System Graft-Versus-Host Disease to Unravel Progressive Visual Loss and Ischemic Stroke Recurrence Post-Allogeneic Hematopoietic Stem Cell Transplant: A Case Report" International Journal of Molecular Sciences 26, no. 5: 2289. https://doi.org/10.3390/ijms26052289
APA StyleCrescenzo, F., Danese, A., Dall’Ora, F., & Turazzini, M. (2025). Chronic Central Nervous System Graft-Versus-Host Disease to Unravel Progressive Visual Loss and Ischemic Stroke Recurrence Post-Allogeneic Hematopoietic Stem Cell Transplant: A Case Report. International Journal of Molecular Sciences, 26(5), 2289. https://doi.org/10.3390/ijms26052289