Parathyroid Involvement by Thyroid Carcinoma: Results from a Single Institution and a Review of the Literature
Abstract
1. Introduction
2. Materials and Methods
3. Results
4. Discussion
4.1. The Rarity of Parathyroid Gland Involvement in Thyroid Carcinoma
4.2. Diagnostic Challenges and the Potential Underestimation of Parathyroid Invasion
4.3. Clinical and Prognostic Significance of Parathyroid Invasion
4.4. Potential Role of Radioactive Iodine Therapy for Parathyroid Involvement
5. Conclusions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Age | Sex | Histologic Type | Tumor Size | T Stage | AJCC Stage | ETE Other than PTG | LN Metastases | Pattern of PTG Metastasis | |
---|---|---|---|---|---|---|---|---|---|
1 | 46 | F | Classic PTC | 0.7 × 0.7 cm | pT1a | I | x | x | Pattern A |
2 | 48 | F | Classic PTC | 0.7 × 0.6 cm | pT1a | I | 0 | x | Pattern A |
3 | 46 | M | Classic PTC | 0.7 × 0.5 cm | pT1a | I | 0 | x | Pattern A |
4 | 29 | F | Classic PTC | 2.2 × 1.7 cm | pT2 | I | 0 | +(8/44) | Pattern A |
5 | 77 | F | Classic PTC | 1.5 × 1.2 cm | pT3b | II | 0 | +(10/22) | Pattern A |
6 | 60 | F | Classic PTC | 3.4 × 6.4 cm | pT3a | II | 0 | x | Pattern A |
7 | 25 | F | Classic PTC | 0.9 × 0.8 cm | pT1a | I | 0 | +(3/5) | Pattern A |
8 | 40 | F | Classic PTC | 0.5 × 0.5 cm | pT1a | I | 0 | x | Pattern A |
9 | 58 | F | Classic PTC | 0.8 × 0.7 cm | pT1a | II | 0 | x | Pattern A |
10 | 30 | F | Classic PTC | 2.4 × 2.8 | pT2 | I | o | +(3/3) | II |
Ref | Journal | Author | Year | N(%) | Mean Age | M/F Ratio | Stage | Type of TC | ETE | Distant Metastases | LN Metastases | PTG Invasion Pattern | Recurrence |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
[3] | Arch. Pathol. Lab. Med. | Tang et al. | 2002 | 20 (2.2%) | 52 | 6: 14 | not reported | PTC-20 | 10 | 1 | 17 | 15: Pattern A 3: Pattern B 2: Pattern C | NR |
[7] | J. Clin. Pathol. | Kakudo et al. | 2004 | 14 (3.9%) | 60.4 | 4: 10 | I/II-2, III/IV-12 | PTC-14 | 13 | 2 lung (2) | 13 | 10: Pattern A 3: Pattern B 1: Pattern C | 2 |
[4] | Endocr. J. | Ito et al. | 2009 | 51 (1.6%) | NR | NR | pT3-30 pT4-21 | Not reported | 29 | NR | NR | NR | 1 |
[2] | World J. Surg. Oncol. | Chrisoplidou et al. | 2012 | 10 (0.5%) | 52.2 | 2: 8 | I-2, II-1, III-5, IV-2 | PTC-5, FVC-2 ATC-1 | 5 | 2 lung (1) Lung and brain (1) | 5 | 9: Pattern A + B 1: Pattern C | NR |
[6] | J. Thyroid. Res. | Papi et al. | 2014 | 10 (0.05%) | 55 | 3: 7 | I-2, III-8 | PTC-6, FVC-3 tall cell-1 | 6 | 0 | 3 | 6: Pattern A 2: Pattern A + B 1: Pattern B | 0 |
[8] | J. Thyroid. Disorders. & Ther. | Al-Qahtani et al. | 2014 | 16 (1.9%) | 57.5 | 4: 12 | pT2-2 pT3-6 pT4-8 | PTC-15 FVC-1 | 13 | 5 lung (4) Bone (1) | 14 | 14: PatternA 2: Pattern C | NR |
Pre-sent | 10 (9.7%) | 46 | 1: 9 | I-7, II-3 | PTC-10 | 9 | 0 | 4 | 10: Pattern A |
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Hong, R. Parathyroid Involvement by Thyroid Carcinoma: Results from a Single Institution and a Review of the Literature. Medicina 2025, 61, 836. https://doi.org/10.3390/medicina61050836
Hong R. Parathyroid Involvement by Thyroid Carcinoma: Results from a Single Institution and a Review of the Literature. Medicina. 2025; 61(5):836. https://doi.org/10.3390/medicina61050836
Chicago/Turabian StyleHong, Ran. 2025. "Parathyroid Involvement by Thyroid Carcinoma: Results from a Single Institution and a Review of the Literature" Medicina 61, no. 5: 836. https://doi.org/10.3390/medicina61050836
APA StyleHong, R. (2025). Parathyroid Involvement by Thyroid Carcinoma: Results from a Single Institution and a Review of the Literature. Medicina, 61(5), 836. https://doi.org/10.3390/medicina61050836