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Quantitative Biology > Genomics

arXiv:0904.0662 (q-bio)
[Submitted on 3 Apr 2009 (v1), last revised 21 Sep 2009 (this version, v2)]

Title:Non-equilibrium thermodynamics of gene expression and transcriptional regulation

Authors:Enrique Hernandez-Lemus
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Abstract: In recent times whole-genome gene expression analysis has turned out to be a highly important tool to study the coordinated function of a very large number of genes within their corresponding cellular environment, especially in relation to phenotypic diversity and disease. A wide variety of methods of quantitative analysis have been developed to cope with high throughput data sets generated by gene expression profiling experiments. Due to the complexity associated with transcriptomics, specially in the case of gene regulation phenomena, most of these methods are of a probabilistic or statistical nature. Even if these methods have reached a central status in the development of an integrative, systematic understanding of the associated biological processes, they very rarely constitute a concrete guide to the actual physicochemical mechanisms behind biological function and the role of these methods is more on a hypotheses generating line. An important improvement could be done with the development of a thermodynamic theory for gene expression and transcriptional regulation that will build the foundations for a proper integration of the vast amount of molecular biophysical data and could lead, in the future, to a systemic view of genetic transcription and regulation.
Comments: 22 pages, 1 table, 4 figures, Corrected text, erroneous figure eliminated
Subjects: Genomics (q-bio.GN)
Cite as: arXiv:0904.0662 [q-bio.GN]
  (or arXiv:0904.0662v2 [q-bio.GN] for this version)
  https://doi.org/10.48550/arXiv.0904.0662
arXiv-issued DOI via DataCite

Submission history

From: Enrique Hernández-Lemus [view email]
[v1] Fri, 3 Apr 2009 22:13:03 UTC (125 KB)
[v2] Mon, 21 Sep 2009 15:04:22 UTC (111 KB)
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