Prenatal diagnosis of fetuses conceived by assisted reproductive technology by karyotyping and chromosomal microarray analysis

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Biochemistry, Biophysics and Molecular Biology

Main article text

 

Introduction

Materials & Methods

Study design and participants

Follow-up of pregnancy outcomes

Karyotype analysis

CMA analysis

Statistical analysis

Ethics approval and consent to participate

Results

Prenatal diagnostic karyotyping data

Prenatal diagnostic findings by CMA

Discussion

Conclusions

Supplemental Information

Raw data of fetuses conceived by assisted reproductive technology including karyotype and CMA

karyotype:1 trisomy 21; 2 Sex chromosome abnormalities; 3 inversion; 4 translocation; 5 other abnormalities; 6 polymorphism; VOUs: 1 pathogenic/likely pathogenic; 2 VOUs

DOI: 10.7717/peerj.14678/supp-1

Raw data of control group

karyotype: 1 trisomy 21; 2 Sex chromosome abnormalities; 3 inversion; 4 translocation; 5 other abnormalities;6 polymorphism; VOUs: 1 pathogenic/likely pathogenic; 2 VOUs

DOI: 10.7717/peerj.14678/supp-2

Additional Information and Declarations

Competing Interests

The authors declare there are no competing interests.

Author Contributions

Huan Guo conceived and designed the experiments, performed the experiments, analyzed the data, prepared figures and/or tables, authored or reviewed drafts of the article, and approved the final draft.

Rui Sheng performed the experiments, prepared figures and/or tables, and approved the final draft.

Xiu Zhang performed the experiments, prepared figures and/or tables, and approved the final draft.

Xuemei Jin performed the experiments, prepared figures and/or tables, and approved the final draft.

Wenjing Gu performed the experiments, authored or reviewed drafts of the article, and approved the final draft.

Ting Liu performed the experiments, authored or reviewed drafts of the article, and approved the final draft.

Haixin Dong performed the experiments, prepared figures and/or tables, and approved the final draft.

Ran Jia conceived and designed the experiments, analyzed the data, authored or reviewed drafts of the article, and approved the final draft.

Clinical Trial Ethics

The following information was supplied relating to ethical approvals (i.e., approving body and any reference numbers):

The Ethics Committee of the Affiliated Hospital of Jining Medical University.

Microarray Data Deposition

The following information was supplied regarding the deposition of microarray data:

File 3 and File 4.

Data Availability

The following information was supplied regarding data availability:

The raw measurements are available in the Supplementary Files.

Funding

The authors received no funding for this work.

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