Effect of body size on the oral pharmacokinetics of oxytetracycline in rainbow trout (Oncorhynchus mykiss)

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Biochemistry, Biophysics and Molecular Biology

Main article text

 

Introduction

Materials & Methods

Chemicals

Animals

Experimental design

Oxytetracycline analysis

Pharmacokinetic analysis

Results

Discussion

Conclusions

Supplemental Information

Author checklist

DOI: 10.7717/peerj.17973/supp-1

Plasma concentrations after oral administration of oxytetracycline at a dose of 60 mg/kg to rainbow trout of different sizes (n = 6, µg/mL)

DOI: 10.7717/peerj.17973/supp-2

Plasma concentrations at sampling times for each rainbow trout (Oncorhynchus mykiss) and all pharmacokinetic parameters of oxytetracycline

DOI: 10.7717/peerj.17973/supp-3

Additional Information and Declarations

Competing Interests

Önder Yıldırım is an Academic Editor for PeerJ.

Author Contributions

Orhan Corum conceived and designed the experiments, performed the experiments, analyzed the data, prepared figures and/or tables, authored or reviewed drafts of the article, and approved the final draft.

Erdinc Turk performed the experiments, authored or reviewed drafts of the article, and approved the final draft.

Duygu Durna Corum performed the experiments, analyzed the data, prepared figures and/or tables, authored or reviewed drafts of the article, and approved the final draft.

Ertugrul Terzi performed the experiments, authored or reviewed drafts of the article, and approved the final draft.

Mustafa Cellat performed the experiments, authored or reviewed drafts of the article, and approved the final draft.

Önder Yıldırım conceived and designed the experiments, prepared figures and/or tables, authored or reviewed drafts of the article, and approved the final draft.

Kamil Uney conceived and designed the experiments, analyzed the data, prepared figures and/or tables, authored or reviewed drafts of the article, and approved the final draft.

Animal Ethics

The following information was supplied relating to ethical approvals (i.e., approving body and any reference numbers):

The experimental was approved (2021/23) by the Kastamonu University Animal Experiments Local Ethics Committee (Kastamonu, Türkiye).

Data Availability

The following information was supplied regarding data availability:

The raw data are available in the Supplemental Files.

Funding

This study was supported by The Coordination of Scientific Research Projects, University of Hatay Mustafa Kemal, Türkiye (Project No. 22.GAP.007). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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