Results 11 to 20 of about 24,814 (247)
Clinical Pharmacology &Therapeutics, Volume 113, Issue 2, Page 435-445, February 2023., 2023 Regulatory authorities put major emphasis on QT (interval)–prolonging properties of new molecular entities. Product information/Summaries of Product Characteristics (SmPCs) of multiple drugs contain warnings or contraindications regarding QT prolongation, e.g., on coadministration of QT‐prolonging drugs (QT drugs).
Melanie I. Then +5 more
wiley +1 more source
Charting the landscape of the environmental exposome
iMeta, Volume 1, Issue 4, December 2022., 2022 We describe the biological and chemical components of the environmental exposomes in three major environmental matrices that are highly relevant to human and social‐economical health—air, soil, and water. We discuss how different exposome components can interact with each other. Finally, we propose a list of outstanding challenges to be tackled to push
Xin Wei +6 more
wiley +1 more source
Neuropsychopharmacology Reports, Volume 42, Issue 4, Page 421-429, December 2022., 2022 Abstract Background Depression is a common disorder that affects patients' quality of life and incurs health system costs. Due to the resistance to treat depression, better understanding of neurophysiology was considered; one of the implications is the glutamatergic system.
Ahmad Shamabadi
wiley +1 more source
Frontiers in Physiology, 2018 Anti-depressant treatment has been found to be associated with the development of Brugada syndrome (BrS) through poorly defined mechanisms. Herein, this study aimed to explore the molecular basis for amitriptyline-induced BrS.
Xi Chen +10 more
doaj +1 more source
Frontiers in Pain Research, 2022 Burning mouth syndrome (BMS) is defined by chronic oral burning sensations without any corresponding abnormalities. Besides amitriptyline, aripiprazole has been reported as a possible medication to manage BMS.
Motoko Watanabe +12 more
doaj +1 more source
Neuropsychopharmacology Reports, Volume 42, Issue 4, Page 457-467, December 2022., 2022 By using a wearable sensor we examined 3‐dimensional acceleration and heart rate variability (HRV) simultaneously in depressive episode of mood disorders. We found reduced activity and altered HRV indices in depressed patients, compared with healthy participants, particularly in males. Moreover, we found that sympathetic load during sleep significantly
Norie Koga +6 more
wiley +1 more source
Balkan Medical Journal, 2016 Background: Amitriptyline is an important cause of mortality due to its cardiovascular toxicity. Aims: To investigate the changes in levels of cardiac S100b protein on amitriptyline-induced cardiotoxicity and also to examine the correlation between ...
Nil Hocaoğlu +5 more
doaj +1 more source
Amitriptyline prescribing in public sector healthcare facilities in the Western Cape, South Africa.
PLoS ONE, 2020 BackgroundInappropriate medication use is a major patient safety concern, especially for the elderly population. Amitriptyline is widely used in primary care in South Africa and a cross-sectional study found that amitriptyline was prescribed potentially ...
Renier Coetzee +3 more
doaj +1 more source
Obesity Science &Practice, Volume 8, Issue 6, Page 784-793, December 2022., 2022 Abstract Objective Rural veterans have high obesity rates. Yet, little is known about this population's engagement with the Veterans Affairs (VA) weight management program (MOVE!). The study objective is to determine whether MOVE! enrollment, anti‐obesity medication use, bariatric surgery use, retention, and outcomes differ by rurality for veterans ...
Kathleen M. Robinson +6 more
wiley +1 more source
Effects of Adding Dexmedetomidine to Amitriptyline on Sciatic Nerve Blockadge in Rats
Medicine Science, 2013 Neurotoxic effects of amitriptyline which is a tricyclic antidepressant limit its use as a local anesthetic. In this study, comparing the effect of combination of different amitrptyline doses with dexmedetomidine on block initiation and termination time ...
Mahmut Durmus +5 more
doaj +1 more source