Results 11 to 20 of about 22,631 (229)

Second-line antitubercular agents and their adverse effects [PDF]

Vojnosanitetski Pregled, 2006
Uprkos cinjenici da su lekovi protiv tuberkuloze otkriveni pre vise od 50 godina i da je tuberkuloza izleciva bolest, ona i danas predstavlja veliki zdravstveni i socijalni problem kako u zemljama u razvoju, tako i u visokorazvijenim zemljama. Prema podacima Svetske zdravstvene organizacije (SZO) u svetu se godisnje registruje 8−10 miliona novoobolelih,
Nagorni-Obradović Ljudmila, Škodrić-Trifunović Vesna   +1 more
doaj   +6 more sources

Discovery of dipiperidines as new antitubercular agents [PDF]

Bioorganic & Medicinal Chemistry Letters, 2009
As part of our ongoing research effort to develop new therapeutics for treatment of tuberculosis (TB), we synthesized a combinatorial library of 10,358 compounds on solid support using a pool-and-split technique and tested the resulting compounds for activity against Mycobacteriumtuberculosis. Structure-activity relationship (SAR) evaluation identified
Elena Bogatcheva, Colleen F. Hanrahan, Ping Chen, Jacqueline Gearhart, Katherine A. Sacksteder, Leo Einck, Carol A. Nacy, Marina Protopopova   +7 more
openalex   +4 more sources

Synthesis of functionalized sulfonamides as antitubercular agents

Phosphorus, Sulfur, and Silicon and the Related Elements, 2023
Using up-to-date methods for synthesis and analysis, 51 sulfonamides were prepared for use as tools in antitubercular drug discovery. The synthetic efforts were centered on varying substituents at three key structural units implicated in antimicrobial activity, namely the sulfonyl group, nitrogen N1 and nitrogen N4.
Michael J. Hearn, Catherine D. Pugh, Michael H. Cynamon   +2 more
openalex   +3 more sources

Novel Pyrimidines as Antitubercular Agents. [PDF]

Antimicrob Agents Chemother, 2018
ABSTRACT Mycobacterium tuberculosis infection is responsible for a global pandemic. New drugs are needed that do not show cross-resistance with the existing front-line therapeutics. A triazine antitubercular hit led to the design of a related pyrimidine family.
Inoyama D, Paget SD, Russo R, Kandasamy S, Kumar P, Singleton E, Occi J, Tuckman M, Zimmerman MD, Ho HP, Perryman AL, Dartois V, Connell N, Freundlich JS.   +13 more
europepmc   +5 more sources

Microbial glycosylation of antitubercular agent chlorflavonin [PDF]

Journal of Bioscience and Bioengineering, 2023
Flavonoids have shown health-benefiting properties, such as antioxidative and anti-inflammatory activities, and are commonly used as nutraceuticals and pharmaceuticals. Although flavonoids are predominantly identified from plants, several filamentous fungal species have also been reported to produce bioactive flavonoids, including chlorflavonin from ...
Jie Ren, Jixun Zhan
openaire   +3 more sources

β-Aminopropioamidoximes derivatives as potential antitubercular agents against anthropozoonotic infections caused by <i>Mycobacterium tuberculosis</i> and <i>Mycobacterium bovis</i>. [PDF]

Vet World
Kayukova L, Bismilda V, Turgenbayev K, Uzakova A, Baitursynova G, Jussipbekov U, Mukanova M, Chingissova L, Dyussembayeva G, Borsynbayeva A, Yerlanuly A, Auyezov A.   +11 more
europepmc   +2 more sources

Improved Synthesis of the Antitubercular Agent SQ109 [PDF]

SynOpen, 2021
AbstractWe present here an improved procedure for the preparation of the promising antitubercular drug SQ109 that is currently in phase Ib/III of clinical trials against Mycobacterium tuberculosis. We investigated and tested the literature synthetic procedure that enables the development of structure–activity relationships and report the observed ...
Antonios Kolocouris, Marianna Stampolaki
openaire   +2 more sources

Knowledge, Attitude, and Practice Toward Antitubercular Agents Among Pulmonary Tuberculosis Patients in Southwestern China: A Cross-Sectional Study [PDF]

Patient Prefer Adherence
Pi Y, Tan J, Yang P, Pan J, Yang X, Xiang M, Li T.   +6 more
europepmc   +2 more sources

Inhalable spray-dried chondroitin sulphate microparticles: effect of different solvents on particle properties and drug activity [PDF]

, 2020
Spray-drying stands as one of the most used techniques to produce inhalable microparticles, but several parameters from both the process and the used materials affect the properties of the resulting microparticles.
Buttini, Francesca, da Costa, Ana M Rosa, Faleiro, Maria Leonor, Flórez Fernández, Noelia, Grenha, Ana, Rodrigues, Susana, Torres, María Dolores   +6 more
core   +1 more source

Synthesis of Triazoloquinoxalines as Antitubercular Agents [PDF]

Bulletin of the Korean Chemical Society, 2011
1,2,4-Triazoles and quinoxalines were found to display various pharmacological activities. Hence a series of 1-aryl-4-methyl-1,2,4-triazolo[4,3-a]quinoxalines were synthesized. Due to various advantages of organic reactions under solvent-free conditions these compounds were developed using iodobenzene diacetate under solvent-free conditions.
V. S. Rao, Dalip Kumar, Kondapalli Venkata Gowri Chandra Sekhar   +2 more
openaire   +2 more sources