Results 11 to 20 of about 4,881 (174)

Production of ovine Pancreatic Ribonuclease and investigation of enzyme characteristics [PDF]

open access: yesپژوهشهای علوم دامی ایران, 2021
Introduction Obviously, the recent decades strategy in cancer therapy, anticancer drug discovery and drug improvement is to characterize, distinguish and validate the most promising cancer-related molecular targets to which new drugs can be designed. The
mahsa Zabetian   +3 more
doaj   +1 more source

Ribonucleases as potential therapeutic agents [PDF]

open access: yesمجله بیوتکنولوژی کشاورزی, 2021
Objective Due to high cytotoxicity effect, ribonucleases (RNases) are known as pharmacological agents with therapeutic potential. The high potential of these enzymes in the destruction of RNA strand and their other substrates and subsequently, cell ...
Masoume Vakili-Azghandi   +3 more
doaj   +1 more source

Extraction and Chromatography of Mouse and Bovine Pancreatic Ribonucleases

open access: hybridJournal of Biological Chemistry, 1960
Sherman R. Dickman   +2 more
openalex   +4 more sources

Engineering and production of recombinant bovine pancreatic ribonuclease enzyme (RNase A) as a potential therapeutic [PDF]

open access: yesمجله بیوتکنولوژی کشاورزی, 2021
Objective  Immunotoxins are one of the most promising ways in therapeutic fields, specially cancer therapy which have a unique toxin-antibody structure, and kill the cancer cell by passing through the cell membrane and entering the target cell.
Masoume Vakili-Azghandi   +3 more
doaj   +1 more source

PEGylated gold nanoparticles-ribonuclease induced oxidative stress and apoptosis in colorectal cancer cells [PDF]

open access: yesBioImpacts, 2020
Introduction: Currently, drug-induced reactive oxygen species (ROS) mediating apoptosis pathway have extensively been investigated in designing effective strategies for colorectal cancer (CRC) chemotherapy.
Mostafa Akbarzadeh Khiavi   +7 more
doaj   +1 more source

Bovine Pancreatic RNase A: An Insight into the Mechanism of Antitumor Activity In Vitro and In Vivo

open access: yesPharmaceutics, 2022
In this investigation, we extensively studied the mechanism of antitumor activity of bovine pancreatic RNase A. Using confocal microscopy, we show that after RNase A penetration into HeLa and B16 cells, a part of the enzyme remains unbound with the ...
Islam Saber Ead Mohamed   +6 more
doaj   +1 more source

A Comparative Study of the Structures of Bovine and Ovine Pancreatic Ribonucleases

open access: hybridJournal of Biological Chemistry, 1959
Christian B. Anfinsen   +3 more
openalex   +4 more sources

Revisiting the Formation of a Native Disulfide Bond: Consequences for Protein Regeneration and Beyond

open access: yesMolecules, 2020
Oxidative protein folding involves the formation of disulfide bonds and the regeneration of native structure (N) from the fully reduced and unfolded protein (R).
Mahesh Narayan
doaj   +1 more source

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