Results 11 to 20 of about 10,656,156 (361)

Copper induces cell death by targeting lipoylated TCA cycle proteins

Science, 2022
Copper is an essential cofactor for all organisms, and yet it becomes toxic if concentrations exceed a threshold maintained by evolutionarily conserved homeostatic mechanisms. How excess copper induces cell death, however, is unknown.
Peter Tsvetkov, S. Coy, Boryana Petrova, Margaret B. Dreishpoon, A. Verma, M. Abdusamad, J. Rossen, Lena M Joesch-Cohen, Ranad Humeidi, R. Spangler, J. Eaton, Evgeni M. Frenkel, M. Kocak, S. M. Corsello, S. Lutsenko, Naama Kanarek, S. Santagata, T. Golub   +17 more
semanticscholar   +1 more source

The ever‐increasing importance of cancer as a leading cause of premature death worldwide

Cancer, 2021
The relative importance of cardiovascular disease (CVD) and cancer as leading causes of premature death are examined in this communication. CVD and cancer are now the leading causes in 127 countries, with CVD leading in 70 countries (including Brazil and
F. Bray, M. Laversanne, E. Weiderpass, I. Soerjomataram   +3 more
semanticscholar   +1 more source

Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China

Journal of Emergency Medicine, 2020
Importance Coronavirus disease 2019 (COVID-19) is an emerging infectious disease that was first reported in Wuhan, China, and has subsequently spread worldwide.
Chao-min Wu, Xiaoyan Chen, Yanping Cai, Jia’an Xia, Xiaoping Zhou, Shan Xu, Hanping Huang, Li Zhang, Xia Zhou, C. Du, Yuye Zhang, Juan Song, Sijiao Wang, Yencheng Chao, Zeyong Yang, Jie Xu, Xin Zhou, Dechang Chen, W. Xiong, Lei Xu, Feng Zhou, Jinjun Jiang, C. Bai, Junhua Zheng, Yuanlin Song   +24 more
semanticscholar   +1 more source

OpenSAFELY: factors associated with COVID-19 death in 17 million patients

Nature, 2020
Coronavirus disease 2019 (COVID-19) has rapidly affected mortality worldwide1. There is unprecedented urgency to understand who is most at risk of severe outcomes, and this requires new approaches for the timely analysis of large datasets.
E. Williamson, A. Walker, K. Bhaskaran, S. Bacon, C. Bates, C. Morton, H. Curtis, A. Mehrkar, D. Evans, P. Inglesby, J. Cockburn, H. Mcdonald, B. Mackenna, L. Tomlinson, I. Douglas, C. Rentsch, R. Mathur, A. Wong, R. Grieve, D. Harrison, H. Forbes, A. Schultze, R. Croker, J. Parry, F. Hester, S. Harper, R. Perera, S. Evans, L. Smeeth, B. Goldacre   +29 more
semanticscholar   +1 more source

Necroptosis, pyroptosis and apoptosis: an intricate game of cell death

Cellular & Molecular Immunology, 2021
Cell death is a fundamental physiological process in all living organisms. Its roles extend from embryonic development, organ maintenance, and aging to the coordination of immune responses and autoimmunity.
D. Bertheloot, E. Latz, B. S. Franklin
semanticscholar   +1 more source

Apoptotic cell death in disease—Current understanding of the NCCD 2023

Cell Death and Differentiation, 2023
Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in mammalian systems have elucidated the key contribution of this ...
I. Vitale, F. Pietrocola, Emma Guilbaud, Stuart A. Aaronson, J. Abrams, D. Adam, M. Agostini, P. Agostinis, E. Alnemri, L. Altucci, I. Amelio, D. Andrews, R. Aqeilan, E. Arama, E. Baehrecke, Siddharth Balachandran, D. Bano, N. Barlev, J. Bartek, N. Bazan, C. Becker, F. Bernassola, M. Bertrand, M. Bianchi, M. Blagosklonny, J. Blander, G. Blandino, K. Blomgren, C. Borner, C. Bortner, P. Bove, P. Boya, C. Brenner, P. Brož, T. Brunner, R. Damgaard, G. Calin, M. Campanella, E. Candi, M. Carbone, D. Carmona-Gutierrez, F. Cecconi, F. K. Chan, Guoqiang Chen, Quan Chen, Youhai H. Chen, E. Cheng, J. Chipuk, J. Cidlowski, A. Ciechanover, G. Ciliberto, M. Conrad, J. Cubillos-Ruiz, P. Czabotar, V. D’Angiolella, M. Daugaard, T. Dawson, V. Dawson, R. De Maria, B. de Strooper, K. Debatin, R. Deberardinis, A. Degterev, G. Del Sal, M. Deshmukh, F. Di Virgilio, M. Diederich, Scott J. Dixon, B. Dynlacht, W. El-Deiry, J. Elrod, K. Engeland, G. Fimia, C. Galassi, C. Ganini, A. García-Sáez, Abhishek D Garg, C. Garrido, E. Gavathiotis, M. Gerlic, Sourav Ghosh, D. Green, L. Greene, H. Gronemeyer, G. Häcker, G. Hajnóczky, J. Hardwick, Y. Haupt, Sudan He, D. Heery, M. Hengartner, C. Hetz, David A Hildeman, H. Ichijo, Satoshi Inoue, M. Jäättelä, Ana Janic, B. Joseph, Philipp J Jost, T. Kanneganti, M. Karin, H. Kashkar, T. Kaufmann, G. Kelly, O. Kepp, A. Kimchi, R. Kitsis, D. Klionsky, R. Kluck, D. Krysko, D. Kulms, Sharad Kumar, S. Lavandero, I. Lavrik, J. Lemasters, Gianmaria Liccardi, A. Linkermann, S. Lipton, R. Lockshin, C. López-Otín, T. Luedde, M. MacFarlane, F. Madeo, W. Malorni, G. Manic, R. Mantovani, S. Marchi, J. Marine, S. Martin, J. Martinou, P. Mastroberardino, J. Medema, P. Mehlen, P. Meier, G. Melino, S. Melino, Edward A. Miao, U. Moll, C. Muñoz-Pinedo, D. Murphy, M. Niklison-Chirou, F. Novelli, G. Núñez, A. Oberst, D. Ofengeim, J. Opferman, M. Oren, M. Pagano, T. Panaretakis, M. Pasparakis, J. Penninger, F. Pentimalli, David M. Pereira, S. Pervaiz, M. Peter, P. Pinton, Giovanni Porta, J. Prehn, H. Puthalakath, G. Rabinovich, K. Rajalingam, K. Ravichandran, M. Rehm, J. Ricci, R. Rizzuto, N. Robinson, C. Rodrigues, B. Rotblat, C. Rothlin, D. Rubinsztein, T. Rudel, A. Rufini, K. Ryan, K. Sarosiek, A. Sawa, E. Sayan, K. Schroder, L. Scorrano, F. Sesti, F. Shao, Yufang Shi, G. Sica, J. Silke, H. Simon, A. Sistigu, A. Stephanou, B. Stockwell, Flavie Strapazzon, A. Strasser, Liming Sun, E. Sun, Qiang Sun, G. Szabadkai, S. Tait, D. Tang, Nektarios Tavernarakis, C. Troy, B. Turk, N. Urbano, P. Vandenabeele, T. Vanden Berghe, M. V. Vander Heiden, J. Vanderluit, A. Verkhratsky, A. Villunger, S. von Karstedt, A. Voss, K. Vousden, D. Vučić, Daniela Vuri, E. Wagner, H. Walczak, D. Wallach, Ruoning Wang, Ying Wang, Achim Weber, Will Wood, T. Yamazaki, Huang-Tian Yang, Z. Zakeri, J. Zawacka-Pankau, Lin Zhang, Haibing Zhang, B. Zhivotovsky, Wenzhao Zhou, M. Piacentini, G. Kroemer, L. Galluzzi   +227 more
semanticscholar   +1 more source

Death doula working practices and models of care: the views of death doula training organisations

BMC Palliative Care, 2023
Background The role of death doula has emerged in recent years, arguably as a result of overwhelming demands on carers, healthcare professionals and service providers in end-of-life care.
Deb Rawlings, Lauren Miller-Lewis, Jennifer Tieman, Kate Swetenham   +3 more
doaj   +1 more source

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

Cell Death and Differentiation, 2018
Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives.
L. Galluzzi, I. Vitale, S. Aaronson, J. Abrams, D. Adam, P. Agostinis, E. Alnemri, L. Altucci, I. Amelio, D. Andrews, M. Annicchiarico-Petruzzelli, A. Antonov, E. Arama, E. Baehrecke, N. Barlev, N. Bazan, F. Bernassola, M. Bertrand, K. Bianchi, M. Blagosklonny, K. Blomgren, C. Borner, P. Boya, C. Brenner, M. Campanella, E. Candi, D. Carmona-Gutierrez, F. Cecconi, F. K. Chan, N. Chandel, E. Cheng, J. Chipuk, J. Cidlowski, A. Ciechanover, G. Cohen, M. Conrad, J. Cubillos-Ruiz, P. Czabotar, V. D’Angiolella, T. Dawson, V. Dawson, V. de Laurenzi, R. De Maria, K. Debatin, R. Deberardinis, M. Deshmukh, N. Di Daniele, F. Di Virgilio, V. Dixit, S. Dixon, C. Duckett, B. Dynlacht, W. El-Deiry, J. Elrod, G. Fimia, S. Fulda, A. García-Sáez, Abhishek D Garg, C. Garrido, E. Gavathiotis, P. Golstein, E. Gottlieb, D. Green, L. Greene, H. Gronemeyer, A. Gross, G. Hajnóczky, J. Hardwick, I. Harris, M. Hengartner, C. Hetz, H. Ichijo, M. Jäättelä, B. Joseph, P. Jost, P. Juin, W. Kaiser, M. Karin, T. Kaufmann, O. Kepp, A. Kimchi, R. Kitsis, D. Klionsky, R. Knight, Sharad Kumar, Sam W. Lee, J. Lemasters, B. Levine, A. Linkermann, S. Lipton, R. Lockshin, C. López-Otín, S. Lowe, Tom Luedde, E. Lugli, M. MacFarlane, F. Madeo, M. Malewicz, W. Malorni, G. Manic, J. Marine, Seamus J. Martin, J. Martinou, J. Medema, P. Mehlen, P. Meier, S. Melino, Edward A. Miao, J. Molkentin, U. Moll, C. Muñoz-Pinedo, S. Nagata, G. Núñez, A. Oberst, M. Oren, M. Overholtzer, M. Pagano, T. Panaretakis, M. Pasparakis, J. Penninger, David M. Pereira, S. Pervaiz, M. Peter, M. Piacentini, P. Pinton, J. Prehn, H. Puthalakath, G. Rabinovich, M. Rehm, R. Rizzuto, C. Rodrigues, D. Rubinsztein, T. Rudel, K. Ryan, E. Sayan, L. Scorrano, F. Shao, Yufang Shi, J. Silke, H. Simon, A. Sistigu, B. Stockwell, A. Strasser, G. Szabadkai, S. Tait, D. Tang, Nektarios Tavernarakis, A. Thorburn, Y. Tsujimoto, B. Turk, T. Vanden Berghe, P. Vandenabeele, M. V. Vander Heiden, A. Villunger, H. Virgin, K. Vousden, D. Vučić, E. Wagner, H. Walczak, D. Wallach, Ying Wang, J. Wells, Will Wood, Junying Yuan, Z. Zakeri, B. Zhivotovsky, L. Zitvogel, G. Melino, G. Kroemer   +168 more
semanticscholar   +1 more source

Entosis: The emerging face of non-cell-autonomous type IV programmed death

Biomedical Journal, 2017
The present review summarizes recent experimental evidences about the existence of the non-cell-autonomous death entosis in physiological and pathophysiological contexts, discusses some aspects of this form of cell death, including morphological ...
Isabelle Martins, Syed Qasim Raza, Laurent Voisin, Haithem Dakhli, Frédéric Law, Dorine De Jong, Awatef Allouch, Maxime Thoreau, Catherine Brenner, Eric Deutsch, Jean-Luc Perfettini   +10 more
doaj   +1 more source

Interrogating Michel Foucault’s counter-conduct: theorising the subjects and practices of resistance in global politics [PDF]

, 2016
Resistance, and its study, is on the rise: visible and politically discernible practices of dissent against sovereignty ad economic exploitation, such as protesting, agitating and occupying have received increased analytical attention in the past decade.
Death, Carl, Malmvig, Helle, Odysseos, Louiza   +2 more
core   +1 more source