Results 11 to 20 of about 58,844 (318)
Human polyomavirus JC virus genome [PDF]
Journal of Virology, 1984 The complete DNA sequence of the human JC virus, which was found to consist of 5,130 nucleotide pairs, is presented. The amino acid sequence of six proteins could be deduced: the early, nonstructural proteins, large T and small t antigens; the late capsid proteins, VP1, VP2, and VP3; and the agnogene product encoded within the late leader sequence ...
Richard J. Frisque +2 more
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JC virus detection and JC virus-specific immunity in natalizumab-treated Multiple Sclerosis patients [PDF]
Journal of Translational Medicine, 2012 Background The use of natalizumab in multiple sclerosis (MS) may favour JC virus reactivation; this phenomenon is usually asymptomatic but can, albeit rarely, evolve into frank progressive multifocal leucoencephalopathy (PML). Methods JCV-specific CD8+ T
Mancuso Roberta +8 more
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JC virus-induced progressive multifocal leukoencephalopathy in a presumably healthy patient [PDF]
BMC Neurology, 2022 Background JC virus (JCV) is common among healthy individuals and remains latent but may be reactivated under immunosuppressive conditions, resulting in progressive multifocal leukoencephalopathy (PML).
Xiang Wang +4 more
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Oligosaccharides as Receptors for JC Virus [PDF]
Journal of Virology, 2002 ABSTRACT JC virus (JCV) belongs to the polyomavirus family of double-stranded DNA viruses and in humans causes a demyelinating disease of the central nervous system, progressive multifocal leukoencephalopathy. Its hemagglutination activity and entry into host cells have been reported to depend on an N-linked glycoprotein containing sialic ...
Rika Komagome +6 more
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Newly diagnosed AIDS patient with cerebellar JC virus [PDF]
IDCases, 2023 We present a case of a 57-year-old man with newly diagnosed acquired immunodeficiency syndrome (AIDS) infection who initially sought care for progressive dysarthria and gait instability.
Sergio Alvarez-Mulett +2 more
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JC Virus Granule Cell Neuronopathy and Lymphoma [PDF]
Open Forum Infectious Diseases, 2018 Abstract Neurological opportunistic infections are going to increase. Clinicians should be aware of the neurological spectrum of JC virus manifestations, including granule cell neuronopathy. Detection of JC virus DNA by polymerase chain reaction in cerebrospinal fluid should be realized in the assessment of a progressive cerebellar ...
Jacques Gasnault +5 more
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Adaptive mutations in the JC virus protein capsid are associated with progressive multifocal leukoencephalopathy (PML). [PDF]
PLoS Genetics, 2009 PML is a progressive and mostly fatal demyelinating disease caused by JC virus infection and destruction of infected oligodendrocytes in multiple brain foci of susceptible individuals.
Shamil R Sunyaev +3 more
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JC Virus Infection of the Brain [PDF]
American Journal of Neuroradiology, 2010 Since its initial description, there have been significant changes in the epidemiology, pathogenesis, and clinical and imaging manifestations of JCV infection of brain. The most common clinical manifestation is PML. Other recently described CNS manifestations are JCE, JCVGCN, and JCM.
Joel K. Curé +4 more
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JC Virus: An oncogenic virus in animals and humans? [PDF]
Seminars in Cancer Biology, 2009 JC virus (JCV) is a human polyomavirus of the Polyomaviridae family, which also includes BK virus and simian vacuolating virus 40 (SV40). JC virus was first isolated in 1971 from the brain of a patient with Progressive Multifocal Leukoencephalopathy (PML). Like other polyomaviruses, JCV has a restricted host range. The virus infects the majority of the
Walter J. Atwood, Melissa S. Maginnis
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Brain tumors of owl monkeys inoculated with JC virus contain the JC virus genome [PDF]
Journal of Virology, 1984 The DNA from astrocytomas that developed in adult owl monkeys 16 to 36 months after intracranial inoculation with JC virus (JCV) was examined for the presence of the JCV genome by hybridization to cloned JCV DNA. The JCV genome was found to be integrated into the cellular DNA in all tumors examined.
Duard L. Walker +5 more
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