Results 11 to 20 of about 536,263 (355)
GABAergic motor neurons bias locomotor decision-making in C. elegans
Nature Communications, 2020 Motor neurons are generally considered to be passive receivers of commands from other neurons. However, this study shows that motor neurons may shape locomotor behaviour by regulating premotor neurons, and that premotor neurons serve to integrate ...
Ping Liu, Bojun Chen, Zhao-Wen Wang
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PLoS Biology, 2022 The ability of terrestrial vertebrates to effectively move on land is integrally linked to the diversification of motor neurons into types that generate muscle force (alpha motor neurons) and types that modulate muscle proprioception, a task that in ...
Mudassar N Khan +14 more
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Neurons other than motor neurons in motor neuron disease.
Histology and histopathology, 2017 Amyotrophic lateral sclerosis (ALS) is typically defined by a loss of motor neurons in the central nervous system. Accordingly, morphological analysis for decades considered motor neurons (in the cortex, brainstem and spinal cord) as the neuronal population selectively involved in ALS.
Ruffoli R +7 more
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Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion. [PDF]
PLoS ONE, 2015 Cell adhesion molecules belonging to the immunoglobulin superfamily (IgSF) control synaptic specificity through hetero- or homophilic interactions in different regions of the nervous system.
Zirong Gu +7 more
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Nature Communications, 2021 Here the authors show in a model of ALS that motor neurons receive stronger inhibitory synaptic inputs than slow motor neurons, and disease progression is associated with specific loss of inhibitory synapses onto fast motor neurons.
Ilary Allodi +4 more
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Determining monkey free choice long before the choice is made: the principal role of prefrontal neurons involved in both decision and motor processes [PDF]
, 2016 When choices are made freely, they might emerge from pre-existing neural activity. However, whether neurons in the prefrontal cortex (PF) show this anticipatory effect and, if so, in which part of the process they are involved is still debated. To answer
Genovesio, Aldo, Marcos, Encarni
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BMJ, 2011 Diane Sackett experienced the first symptoms of motor neurone disease in 2004, and died in September 2009. Diane’s husband, Brian, was her main carer.
Mohamed Sakel, Brian Sackett
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Mutant UBQLN2P497H in motor neurons leads to ALS-like phenotypes and defective autophagy in rats [PDF]
, 2018 Mutations in ubiquilin2 (UBQLN2) have been linked to abnormal protein aggregation in amyotrophic lateral sclerosis (ALS). The mechanisms underlying UBQLN2-related neurodegenerative diseases remain unclear.
Chen, Tianhong +4 more
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Postgraduate Medical Journal, 2002 Abstract Motor neurone disease (MND), or amyotrophic lateral sclerosis (ALS), is a neurodegenerative disorder of unknown aetiology. Progressive motor weakness and bulbar dysfunction lead to premature death, usually from respiratory failure. Confirming the diagnosis may initially be difficult until the full clinical features are manifest.
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Disease Models & Mechanisms, 2016 Spinal muscular atrophy (SMA), characterized by specific degeneration of spinal motor neurons, is caused by mutations in the survival of motor neuron 1, telomeric (SMN1) gene and subsequent decreased levels of functional SMN. How the deficiency of SMN, a
Chong-Chong Xu +4 more
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