Morphological characteristics of motor neurons do not determine their relative susceptibility to degeneration in a mouse model of severe spinal muscular atrophy. [PDF]
PLoS ONE, 2012 Spinal muscular atrophy (SMA) is a leading genetic cause of infant mortality, resulting primarily from the degeneration and loss of lower motor neurons.
Sophie R Thomson +6 more
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Neurotrophic requirements of human motor neurons defined using amplified and purified stem cell-derived cultures. [PDF]
PLoS ONE, 2014 Human motor neurons derived from embryonic and induced pluripotent stem cells (hESCs and hiPSCs) are a potentially important tool for studying motor neuron survival and pathological cell death.
Nuno Jorge Lamas +6 more
doaj +5 more sources
Onecut-dependent Nkx6.2 transcription factor expression is required for proper formation and activity of spinal locomotor circuits. [PDF]
, 2020 In the developing spinal cord, Onecut transcription factors control the diversification of motor neurons into distinct neuronal subsets by ensuring the maintenance of Isl1 expression during differentiation.
A Espana +36 more
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BMJ, 2011 Diane Sackett experienced the first symptoms of motor neurone disease in 2004, and died in September 2009. Diane’s husband, Brian, was her main carer.
Brian, Sackett, Mohamed, Sakel
openaire +2 more sources
GABAergic motor neurons bias locomotor decision-making in C. elegans
Nature Communications, 2020 Motor neurons are generally considered to be passive receivers of commands from other neurons. However, this study shows that motor neurons may shape locomotor behaviour by regulating premotor neurons, and that premotor neurons serve to integrate ...
Ping Liu, Bojun Chen, Zhao-Wen Wang
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Distinct Corticostriatal GABAergic Neurons Modulate Striatal Output Neurons and Motor Activity
Cell Reports, 2017 Summary: The motor cortico-basal ganglion loop is critical for motor planning, execution, and learning. Balanced excitation and inhibition in this loop is crucial for proper motor output.
Sarah Melzer +5 more
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Neurons other than motor neurons in motor neuron disease.
Histology and histopathology, 2017 Amyotrophic lateral sclerosis (ALS) is typically defined by a loss of motor neurons in the central nervous system. Accordingly, morphological analysis for decades considered motor neurons (in the cortex, brainstem and spinal cord) as the neuronal population selectively involved in ALS.
Ruffoli R +7 more
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Determining monkey free choice long before the choice is made: the principal role of prefrontal neurons involved in both decision and motor processes [PDF]
, 2016 When choices are made freely, they might emerge from pre-existing neural activity. However, whether neurons in the prefrontal cortex (PF) show this anticipatory effect and, if so, in which part of the process they are involved is still debated. To answer
Genovesio, Aldo, Marcos, Encarni
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Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion. [PDF]
PLoS ONE, 2015 Cell adhesion molecules belonging to the immunoglobulin superfamily (IgSF) control synaptic specificity through hetero- or homophilic interactions in different regions of the nervous system.
Zirong Gu +7 more
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PLoS Biology, 2022 The ability of terrestrial vertebrates to effectively move on land is integrally linked to the diversification of motor neurons into types that generate muscle force (alpha motor neurons) and types that modulate muscle proprioception, a task that in ...
Mudassar N Khan +14 more
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