Results 11 to 20 of about 298,029 (336)

A potential biomarker of cognitive impairment: The olfactory dysfunction and its genes expression

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1884-1897, December 2022., 2022
Abstract Objective Accumulation evidence has reported that olfactory impairment may be an essential clinical marker and predictor of mild cognitive impairment or Alzheimer's disease. Method Participants were enrolled in the population‐based, prospective study in Fuxin county, Liaoning province, China between 2019 and 2021.
Jiayi Song, Jiahui Xu, Wei Yuan, Ruixue Li, Hui Guo, Hanshu Gao, Cuiying Gu, Wenjing Feng, Yanan Ma, Haiqiang Guo, Zhaoqing Sun, Liqiang Zheng   +11 more
wiley   +1 more source

The clinical spectrum of SMA‐PME and in vitro normalization of its cellular ceramide profile

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1941-1952, December 2022., 2022
Abstract Objective The objectives of this study were to define the clinical and biochemical spectrum of spinal muscular atrophy with progressive myoclonic epilepsy (SMA‐PME) and to determine if aberrant cellular ceramide accumulation could be normalized by enzyme replacement.
Michelle M. Lee, Graeme S. V. McDowell, Darryl C. De Vivo, Daniel Friedman, Samuel F. Berkovic, Maria Spanou, Argirios Dinopoulos, Katheryn Grand, Pedro A. Sanchez‐Lara, Michelle Allen‐Sharpley, Jodi Warman‐Chardon, Alexander Solyom, Thierry Levade, Edward H. Schuchman, Steffany A. L. Bennett, David A. Dyment, Toni S. Pearson   +16 more
wiley   +1 more source

Brain magnetic resonance imaging predictors in anti‐N‐methyl‐D‐aspartate receptor encephalitis

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1974-1984, December 2022., 2022
Abstract Objective Brain magnetic resonance imaging (MRI) findings in anti‐N‐methyl‐D‐aspartate receptor (NMDAR) encephalitis are nonspecific and rarely have obvious associations with clinical characteristics and outcomes. This study aimed to comprehensively describe the MRI features of patients with NMDAR encephalitis, examine their associations with ...
Ying‐Ying Zhao, Bing Han, Cui‐Hong Qin, Xue‐Xiu Shi, Wen‐Jing Yun, Meng Wang, Bo Yuan, Tong‐Wen Sun, Hai‐Xu Wang   +8 more
wiley   +1 more source

A Novel Group Cognitive Behavioral Therapy Approach to Adult Non-rapid Eye Movement Parasomnias

Frontiers in Psychiatry, 2021
Background: Following the success of Cognitive Behavioral Therapy (CBT) for insomnia, there has been a growing recognition that similar treatment approaches might be equally beneficial for other major sleep disorders, including non-rapid eye movement ...
David O'Regan, David O'Regan, Alexander Nesbitt, Alexander Nesbitt, Nazanin Biabani, Panagis Drakatos, Panagis Drakatos, Hugh Selsick, Hugh Selsick, Guy D. Leschziner, Guy D. Leschziner, Guy D. Leschziner, Joerg Steier, Joerg Steier, Adam Birdseye, Iain Duncan, Seán Higgins, Seán Higgins, Veena Kumari, Veena Kumari, Paul R. Stokes, Allan H. Young, Ivana Rosenzweig, Ivana Rosenzweig   +23 more
doaj   +1 more source

Sleep quality, daytime sleepiness and daytime functioning among Thai obstructive sleep apnea patients receiving continuous positive airway pressure therapy [PDF]

Journal of Health Research, 2022
Purpose – The purpose is to assess the effectiveness of continuous positive airway pressure (CPAP) treatment on sleep quality, daytime sleepiness and daytime functioning among Thai obstructive sleep apnea (OSA) patients.
Theerakorn Theerakittikul, Jindarat Chaiard, Jirawan Deeluea   +2 more
doaj   +1 more source

A Large Collection of Real-world Pediatric Sleep Studies [PDF]

Sci Data 9, 421 (2022), 2021
Despite being crucial to health and quality of life, sleep -- especially pediatric sleep -- is not yet well understood. This is exacerbated by lack of access to sufficient pediatric sleep data with clinical annotation. In order to accelerate research on pediatric sleep and its connection to health, we create the Nationwide Children's Hospital (NCH ...
arxiv   +1 more source

NLRP3 Deficiency Protects Against Intermittent Hypoxia-Induced Neuroinflammation and Mitochondrial ROS by Promoting the PINK1-Parkin Pathway of Mitophagy in a Murine Model of Sleep Apnea

Frontiers in Immunology, 2021
Obstructive sleep apnea (OSA) associated neurocognitive impairment is mainly caused by chronic intermittent hypoxia (CIH)-triggered neuroinflammation and oxidative stress. Previous study has demonstrated that mitochondrial reactive oxygen species (mtROS)
Xu Wu, Xu Wu, Linjing Gong, Liang Xie, Liang Xie, Wenyu Gu, Xinyuan Wang, Zilong Liu, Zilong Liu, Shanqun Li, Shanqun Li   +10 more
doaj   +1 more source

Digital CBTI hubs as a treatment augmentation strategy in military clinics: study protocol for a pragmatic randomized clinical trial

Trials, 2023
Background Chronic insomnia is the most prevalent sleep disorder among military service members, and it compromises readiness, performance, and physical and mental health. Cognitive behavioral treatment for insomnia (CBTI) is the standard of care for the
Anne Germain, Megan Wolfson, Matthew S. Brock, Brian O’Reilly, Hunter Hearn, Shelley Knowles, Vincent Mysliwiec, Meredith L. Wallace   +7 more
doaj   +1 more source

The optimal dose of Ramelteon for the better treatment adherence of delayed sleep–wake phase disorder: a dropout rate study

Frontiers in Neurology, 2023
BackgroundEvidence regarding the effectiveness of melatonin receptor agonists in treating delayed sleep–wake phase disorder (DSWPD) remains limited. This study aimed to determine the optimal dose of ramelteon, a melatonin receptor agonist, for the better
Shunsuke Takagi, Shunsuke Takagi, Shunsuke Takagi, Shunsuke Takagi, Genichi Sugihara, Hidehiko Takahashi, Hidehiko Takahashi, Yuichi Inoue, Yuichi Inoue   +8 more
doaj   +1 more source

Executive Functioning and Personality Traits in Insomnia Disorder: A Preliminary Report on the Clinical Importance of Objective and Subjective Reduction of Total Sleep Time

Mediterranean Journal of Clinical Psychology, 2020
To confirm and extend previous findings on the relationships between executive functioning (EF) and insomnia, as well as the available evidence on the associations between personality traits and insomnia, 30 consecutively-admitted insomnia participants ...
Antonella Somma, Sara Marelli, Margherita Barranca, Giulia Gialdi, Chiara Lucini, Alessandra Castelnuovo, Samantha Mombelli, Luigi Ferini-Strambi, Andrea Fossati   +8 more
doaj   +1 more source