Within-session variability as quality control for oscillometry in health and disease
ERJ Open Research, 2021 Oscillometry is increasingly adopted in respiratory clinics, but many recommendations regarding measurement settings and quality control remain subjective.
Louise M. Harkness +8 more
doaj +1 more source
The nature of small-airway obstruction in chronic obstructive pulmonary disease.
New England Journal of Medicine, 2004 BACKGROUND Chronic obstructive pulmonary disease (COPD) is a major public health problem associated with long-term exposure to toxic gases and particles. We examined the evolution of the pathological effects of airway obstruction in patients with COPD.
J. Hogg +10 more
semanticscholar +1 more source
Expression of the SARS-CoV-2 ACE2 Receptor in the Human Airway Epithelium
American Journal of Respiratory and Critical Care Medicine, 2020 Rationale: Infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease (COVID-19), a predominantly respiratory illness.
Haijun Zhang +6 more
semanticscholar +1 more source
Reduced Local Response to Corticosteroids in Eosinophilic Chronic Rhinosinusitis with Asthma
Biomolecules, 2020 Eosinophilic chronic rhinosinusitis (ECRS), a subgroup of chronic rhinosinusitis with nasal polyps, is recognized as a refractory eosinophilic disorder characterized by both upper and lower airway inflammation.
Yoshiki Kobayashi +7 more
doaj +1 more source
Airway Resistance, Airway Conductance, Specific Airway Resistance, and Specific Airway Conductance in Children [PDF]
Pediatric Research, 1983 In 82 healthy children and in asthmatic children before and during positive allergen provocation test, airway resistance (Raw), airway conductance (Gaw), specific airway resistance (SRaw), and specific airway conductance (SGaw) were measured by body plethysmography during quiet breathing.
M. Leben, H von der Hardt
openaire +3 more sources
A revised airway epithelial hierarchy includes CFTR-expressing ionocytes
Nature, 2018 The airways of the lung are the primary sites of disease in asthma and cystic fibrosis. Here we study the cellular composition and hierarchy of the mouse tracheal epithelium by single-cell RNA-sequencing (scRNA-seq) and in vivo lineage tracing.
Daniel T. Montoro +28 more
semanticscholar +1 more source
TGF-β1 Activates Nasal Fibroblasts through the Induction of Endoplasmic Reticulum Stress
Biomolecules, 2020 (1) Background: Tissue remodeling and extracellular matrix (ECM) accumulation contribute to the development of chronic inflammatory diseases of the upper airway.
Jae-Min Shin +5 more
doaj +1 more source
Lower airway dysbiosis affects lung cancer progression.
Cancer Discovery, 2020 In lung cancer, enrichment of the lower airway microbiota with oral commensals commonly occurs and ex vivo models support that some of these bacteria can trigger host transcriptomic signatures associated with carcinogenesis. Here, we show that this lower
Jun-Chieh J. Tsay +41 more
semanticscholar +1 more source
Role of IL‐25, IL‐33, and TSLP in triggering united airway diseases toward type 2 inflammation
Allergy. European Journal of Allergy and Clinical Immunology, 2020 Under the concept of "united airway diseases," the airway is a single organ wherein upper and lower airway diseases are commonly comorbid. The upper and lower airways are lined with respiratory epithelium that plays a vital role in immune surveillance ...
H. Hong +4 more
semanticscholar +1 more source
Airway Remodeling in Asthma: Tumor of the Airway? [PDF]
Respiration, 2013 properties and the therapy has been shown to have an acute and sustained beneficial effect on lung function (changes in FEV 1 ) in chronic persistent asthma [6] . Antileukotrienes do not have major side effects and appear to be well tolerated by most patients [7] , but a limitation of their widespread use may be due to the large percentage of ...
Stephan F. van Eeden, Chun Y. Seow
openaire +3 more sources