Results 21 to 30 of about 24,814 (247)
Clinics, 2010 OBJECTIVE: The present study was designed to further investigate the effect of amitriptyline, a classical tricyclic antidepressant, on carrageenan-induced paw edema in rats. METHODS: First, amitriptyline was administered intraperitoneally (i.p.) at doses
Valiollah Hajhashemi +4 more
doaj +1 more source
Old Drugs for JAK-STAT Pathway Inhibition in COVID-19 [PDF]
, 2020 The pandemic threat of COVID-19 with more than 37 million cases in which about 5 percent entering critical stage characterized by cytokine storm and hyperinflammatory condition, the state more often leads to admission to intensive care unit with rapid mortality.
arxiv +1 more source
Cytoprotective Effects of Melatonin Against Amitriptyline-Induced Toxicity in Isolated Rat Hepatocytes [PDF]
Advanced Pharmaceutical Bulletin, 2015 Purpose: Amitriptyline, one of the commonly used tricyclic antidepressants, caused rare but severe hepatotoxicity in patients who received it continuously. Previous findings showed that the intermediate metabolites of amitriptyline produced by CYP450 are
Shohreh Taziki +3 more
doaj +1 more source
Brazilian Journal of Pharmaceutical Sciences, 2018 Interactions between herbs and drugs may increase or decrease the pharmacological or toxicological effects of either component. Experimental data on the pharmacokinetic interactions between herbal products and drugs are limited.
Fowad Khurshid +6 more
doaj +1 more source
Nepal Journal of Neuroscience, 2021 Introduction Primary headache disorder, characterized by recurrent headache is the most prevalent disease leading to widespread ill health and impaired quality of life.
Babu Ram Pokharel +5 more
doaj +1 more source
Amitriptyline-mediated cognitive enhancement in aged 3×Tg Alzheimer's disease mice is associated with neurogenesis and neurotrophic activity. [PDF]
PLoS ONE, 2011 Approximately 35 million people worldwide suffer from Alzheimer's disease (AD). Existing therapeutics, while moderately effective, are currently unable to stem the widespread rise in AD prevalence.
Wayne Chadwick +11 more
doaj +1 more source
Cardiotoxicity of amitriptyline and doxepin [PDF]
Clinical Pharmacology and Therapeutics, 1981 The cardiotoxicity of the tricyclic antidepressants amitriptyline and doxepin were compared in an animal with acute overdose. The mean repetitive extrasystole threshold (RET) decreased 71.5% with amitriptyline and 27.5% with doxepin (mean blood levels 933 ng/ml and 1889 ng/ml). Physostigmine reversed these effects.
Tobis, Jonathan M, Aronow, Wilbert S
openaire +4 more sources
Basic &Clinical Pharmacology &Toxicology, Volume 132, Issue 1, Page 111-119, January 2023., 2023 Abstract Information regarding deaths caused by poisoning or adverse effects of medication in Danish persons not using illicit narcotic drugs (PNUIDs) is sparse. To characterize aetiology, demographics, and death scene, we reviewed all legal autopsies performed at Aarhus University from 2017 to 2019 and isolated 96 deaths caused by medications in ...
Charlotte U. Andersen +4 more
wiley +1 more source
Frontiers in Psychiatry, 2022 Auditory hallucination is usually associated with psychiatric diseases and organic brain illness. It was rarely found as adverse events of antidepressants.
Motoko Watanabe +8 more
doaj +1 more source
European Journal of Neurology, Volume 30, Issue 1, Page 224-234, January 2023., 2023 How long is the response to galcanezumab in real life? Findings: In this longitudinal cohort study, considering 1‐year treatment, the included 191 patients presented a 50% response rate (RR) to galcanezumab for a median of 9 cumulative months. Favorable predictive factors were monthly migraine days ≥50% RR in the first month of therapy, and effective ...
Fabrizio Vernieri +32 more
wiley +1 more source