Results 21 to 30 of about 360,464 (238)
Optimal Allocation of Gold Standard Testing under Constrained Availability: Application to Assessment of HIV Treatment Failure [PDF]
, 2020 The World Health Organization (WHO) guidelines for monitoring the effectiveness of HIV treatment in resource-limited settings (RLS) are mostly based on clinical and immunological markers (e.g., CD4 cell counts). Recent research indicates that the guidelines are inadequate and can result in high error rates.
arxiv +1 more source
Acta Scientiarum. Health Sciences, 2015 While a 42-year-old male patient was being prepared for deceased-donor renal transplantation, anti-HLA-A2 antibodies were detected in the serum by enzyme-linked immunosorbent assay (ELISA) method.
Hugo Mendonça Mundim +5 more
doaj +1 more source
Iranian Journal of Microbiology, 2021 Background and Objectives: Bacillus probiotics have been recently considered in biotechnological researches, and food additives. The present study was aimed to investigate the effects of Bacillus subtilis probiotics (PY79 and ATCC 6633) and their ...
Raheleh Ostovan +3 more
doaj
PLoS ONE, 2017 The role of natural killer (NK) cell function in HIV disease especially in the setting of long-term antiretroviral therapy (ART) and viral suppression is not fully understood.
Zhenwu Luo +9 more
semanticscholar +1 more source
Journal of Pancreatology, 2020 Pancreatic ductal adenocarcinoma (PDAC) has a high mortality rate and is notoriously refractory to multiple cancer treatments. In recent years, cancer therapy has expanded beyond traditional cytotoxic chemotherapy to targeted agents and immunotherapy ...
D. Siolas +2 more
semanticscholar +1 more source
Bayesian Models and Decision Algorithms for Complex Early Phase Clinical Trials [PDF]
Statistical Science 2010, Vol. 25, No. 2, 227-244, 2010 An early phase clinical trial is the first step in evaluating the effects in humans of a potential new anti-disease agent or combination of agents. Usually called "phase I" or "phase I/II" trials, these experiments typically have the nominal scientific goal of determining an acceptable dose, most often based on adverse event probabilities.
arxiv +1 more source
Neoplasia: An International Journal for Oncology Research, 2000 Immunoglobulin T-cell receptors (IgTCRs) combine the specificity of antibodies with the potency of cellular killing by grafting antibody recognition domains onto TCR signaling chains.
C.O. Yun +4 more
doaj +1 more source
Search and capture efficiency of dynamic microtubules for centrosome relocation during IS formation [PDF]
Biophysical Journal (2019), 2019 Upon contact with antigen presenting cells (APCs) cytotoxic T lymphocytes (T cells) establish a highly organized contact zone denoted as immunological synapse (IS). The formation of the IS implies relocation of the microtubule organizing center (MTOC) towards the contact zone, which necessitates a proper connection between MTOC and IS via dynamic ...
arxiv +1 more source
Smooth and probabilistic PARAFAC model with auxiliary covariates [PDF]
arXiv, 2021 In immunological and clinical studies, matrix-valued time-series data clustering is increasingly popular. Researchers are interested in finding low-dimensional embedding of subjects based on potentially high-dimensional longitudinal features and investigating relationships between static clinical covariates and the embedding.
arxiv
Journal of Immunology, 2019 Key Points IgG fucosylation status and target cell Ag density determine NK cell ADCC. Aspecific serum IgG bound to FcγRIIIa and target cell glycocalyx limit NK cell ADCC. NK cell FcγRIIIa is preferentially occupied by high-affinity afucosylated serum IgG.
A. R. Temming +13 more
semanticscholar +1 more source