Results 21 to 30 of about 10,656,156 (361)

Copy Number Variation and Structural Genomic Findings in 116 Cases of Sudden Unexplained Death between 1 and 28 Months of Age

Advanced Genetics, 2023
In sudden unexplained death in pediatrics (SUDP) the cause of death is unknown despite an autopsy and investigation. The role of copy number variations (CNVs) in SUDP has not been well‐studied. Chromosomal microarray (CMA) data are generated for 116 SUDP
Catherine A. Brownstein, Elise Douard, Robin L. Haynes, Hyun Yong Koh, Alireza Haghighi, Christine Keywan, Bree Martin, Sanda Alexandrescu, Elisabeth A. Haas, Sara O. Vargas, Monica H. Wojcik, Sébastien Jacquemont, Annapurna H. Poduri, Richard D. Goldstein, Ingrid A. Holm   +14 more
doaj   +1 more source

PTEN-lipid Binding Assay

Bio-Protocol, 2013
The lipid and protein interactions are an integral and important part of many cellular signaling pathways. The understanding of the selective and specific interaction of the given lipid molecule with the target protein is required for studying cellular ...
Sridhar Kavela, Swapnil Shinde, Subbareddy Maddika   +2 more
doaj   +1 more source

Controls on the spatial distribution of oceanic δ¹³C_DIC [PDF]

, 2013
We describe the design and evaluation of a large ensemble of coupled climate–carbon cycle simulations with the Earth system model of intermediate complexity GENIE.
Death, R. M., Edwards, N. R., Holden, P. B., Müller, S. A., Oliver, K. I. C., Ridgwell, A.   +5 more
core   +3 more sources

Trial watch: Immunogenic cell death induction by anticancer chemotherapeutics

OncoImmunology, 2017
The expression “immunogenic cell death” (ICD) refers to a functionally unique form of cell death that facilitates (instead of suppressing) a T cell-dependent immune response specific for dead cell-derived antigens. ICD critically relies on the activation
Abhishek D. Garg, Sanket More, Nicole Rufo, Odeta Mece, Maria Livia Sassano, Patrizia Agostinis, Laurence Zitvogel, Guido Kroemer, Lorenzo Galluzzi   +8 more
doaj   +1 more source

Macrophage biology plays a central role during ionizing radiation-elicited tumor response

Biomedical Journal, 2017
Radiation therapy is one of the major therapeutic modalities for most solid tumors. The anti-tumor effect of radiation therapy consists of the direct tumor cell killing, as well as the modulation of tumor microenvironment and the activation of immune ...
Qiuji Wu, Awatef Allouch, Isabelle Martins, Nazanine Modjtahedi, Eric Deutsch, Jean-Luc Perfettini   +5 more
doaj   +1 more source

Cell-in-cell structure mediates in-cell killing suppressed by CD44

Cell Discovery, 2022
Penetration of immune cells into tumor cells was believed to be immune-suppressive via cell-in-cell (CIC) mediated death of the internalized immune cells.
Yan Su, Hongyan Huang, Tianzhi Luo, You Zheng, Jie Fan, He Ren, Meng Tang, Zubiao Niu, Chenxi Wang, Yuqi Wang, Zhengrong Zhang, Jianqing Liang, Banzhan Ruan, Lihua Gao, Zhaolie Chen, Gerry Melino, Xiaoning Wang, Qiang Sun   +17 more
doaj   +1 more source

Social Death [PDF]

, 2016
This review will outline various ways in which the notion of 'social death’ can be understood, and how they can be related to clinical practice. The idea of social death is used to analytically represent how someone can be identified and treated as if ...
Borgstrom, Brittain, Caswell, E. Borgstrom, Králová, Mulkay, Schneider, Sweeting, Sweeting, Unruh, Walter   +10 more
core   +1 more source

“They want you to know who they really are inside of the old visage”—biographical storytelling as a methodological tool to explore emotional challenges in old age

BMC Geriatrics, 2023
Background Growing older is often associated with resilience, contentedness and inner growth. Older people however are also at risk of confronting unique emotional challenges as a result of varied ageing-related experiences.
Chao Fang, Alastair Comery, Sam Carr
doaj   +1 more source

Adverse effects of prenatal tobacco smoke exposure on biological parameters of the developing brainstem

Neurobiology of Disease, 2005
We aimed to study the consequences of chronic exposure to tobacco smoke in utero on the morphological and functional maturation of the brainstem by comparing stillbirths of smoker mothers versus nonsmoker mothers.
Anna Maria Lavezzi, Giulia Ottaviani, Luigi Matturri   +2 more
doaj   +1 more source

Acid sphingomyelinase-dependent autophagic degradation of GPX4 is critical for the execution of ferroptosis

Cell Death and Disease, 2021
Ferroptosis is a type of regulated cell death characterized by ROS accumulation and devastating lipid peroxidation (LPO). The role of acid sphingomyelinase (ASM), a key enzyme in sphingolipid metabolism, in the induction of apoptosis has been studied ...
Faisal Thayyullathil, Anees Rahman Cheratta, Ameer Alakkal, Karthikeyan Subburayan, Siraj Pallichankandy, Yusuf A. Hannun, Sehamuddin Galadari   +6 more
doaj   +1 more source