Results 21 to 30 of about 128,340 (326)

Clinical implications of m6A‐related regulators YTHDF1 and YTHDF2 in hepatocellular carcinoma

Precision Medical Sciences, Volume 11, Issue 4, Page 174-185, December 2022., 2022
YTHDF1 and YTHDF2 are important regulators related to m6A, and their roles in Hepatocellular carcinoma (HCC) have been limited and contradictory in previous studies. In this study, the clinical implications of YTHDF1 and YTHDF2 in HCC were first explored using bioinformatics in the TCGA database.
Nanfang Qu, Xuemei Zhang, Xianbin Wu, Xia Zhou, Zhejun Deng, Lei Ma, Yanhua Liu, Wenhong Ge, Huanghuang Jiang, Longkuan Xu, Haixing Jiang   +10 more
wiley   +1 more source

Factors Associated With Rates of HBsAg Seroclearance in Adults With Chronic HBV Infection: A Systematic Review and Meta-analysis.

Gastroenterology, 2019
BACKGROUND & AIMS Seroclearance of hepatitis B surface antigen (HBsAg) is a marker for clearance of chronic hepatitis B virus (HBV) infection, but reported annual incidence rates of HBsAg seroclearance vary.
Y. Yeo, H. Ho, Hwai I. Yang, T. Tseng, T. Hosaka, H. Trinh, Min-Sun Kwak, Young Min Park, J. Fung, M. Buti, Manuel Rodríguez, S. Treeprasertsuk, C. Preda, T. Ungtrakul, P. Charatcharoenwitthaya, Xiangyong Li, Jiayi Li, Jian Q. Zhang, M. Le, Bin Wei, B. Zou, A. Le, Donghak Jeong, Nicholas Chien, Leslie Y. Kam, Chiao-Chin Lee, M. Riveiro‐Barciela, D. Istratescu, T. Sriprayoon, Y. Chong, T. Tanwandee, M. Kobayashi, F. Suzuki, M. Yuen, Hyo‐suk Lee, J. Kao, A. Lok, Chun-Ying Wu, M. Nguyen   +38 more
semanticscholar   +1 more source

Modelling hepatitis D virus RNA and HBsAg dynamics during nucleic acid polymer monotherapy suggest rapid turnover of HBsAg

Scientific Reports, 2020
Hepatitis D virus (HDV) requires hepatitis B surface antigen (HBsAg) for its assembly and release. Current HBV treatments are only marginally effective against HDV because they fail to inhibit HBsAg production/secretion.
L. Shekhtman, S. Cotler, L. Hershkovich, S. Uprichard, M. Bazinet, V. Pantea, V. Cebotarescu, Lilia Cojuhari, P. Jimbei, A. Krawczyk, U. Dittmer, A. Vaillant, H. Dahari   +12 more
semanticscholar   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Hepatitis B virus movement through the hepatocyte: An update

Biology of the Cell, Volume 114, Issue 12, Page 325-348, December 2022., 2022
Model of intracellular trafficking routes of progeny hepatitis B virus (HBV) viral and subviral particles through the liver cell involving nucleocytoplasmic shuttling, movement through the ER/Golgi secretory pathway, and budding and release through the multivesicular body (MVB) and/or secretory autophagosomes (sAP) axis.
Reinhild Prange
wiley   +1 more source

Detection of early-stage hepatocellular carcinoma in asymptomatic HBsAg-seropositive individuals by liquid biopsy

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance We detected cfDNA somatic mutations in combination with protein markers to efficiently identify early stage HCC from asymptomatic HBsAg-seropositive individuals in a community population.
C. Qu, Yuting Wang, Pei-pei Wang, Kun-Tian Chen, Min-jie Wang, H. Zeng, Jianquan Lu, Q. Song, B. Diplas, D. Tan, C. Fan, Q. Guo, Zheng Zhu, H. Yin, Liping Jiang, Xixi Chen, Hui Zhao, Huan He, Yong Wang, Guangyu Li, X. Bi, Xinming Zhao, Tao-yang Chen, Hongping Tang, Chuanguo Lv, Dongmei Wang, Wanqing Chen, Jianguo Zhou, Hong Zhao, Jianqiang Cai, Xiaoyue Wang, Sizhen Wang, Hai Yan, Y. Zeng, W. Cavenee, Y. Jiao   +35 more
semanticscholar   +1 more source

Identification by enzyme immunoassay of escape mutants S143L and G145R of hepatitis B virus (Hepadnaviridae: Orthohepadnavirus: Hepatitis B virus)

Вопросы вирусологии, 2022
Introduction. The achievement of the goal of the World Health Organization to eliminate viral hepatitis B by 2030 seems to be problematic partly due to the presence of escape mutants of its etiological agent, hepatitis B virus (HBV) (iHepadnaviridae ...
M. V. Konopleva, A. A. Feldsherova, D. A. Elgort, T. A. Tupoleva, N. A. Kokhanovskaya, V. N. Pankratova, T. A. Semenenko, A. P. Suslov   +7 more
doaj   +1 more source

Immunization against Hepatitis B Surface Antigen (HBsAg) in a Cohort of Nursing Students Two Decades after Vaccination: Surprising Feedback [PDF]

, 2019
Health-care students can be exposed to biological risks during university training. The persistence of long-term immunogenicity against hepatitis B virus (HBV) was analyzed in a cohort of nursing students two decades after primary vaccination. A total of
Claudio Costantino, Emanuele Amodio, Francesco Vitale, Maria Gabriella Verso   +3 more
core   +1 more source

Breakdown of adaptive immunotolerance induces hepatocellular carcinoma in HBsAg-tg mice

Nature Communications, 2019
Hepatitis B virus (HBV) can induce chronic inflammation, cirrhosis, and eventually hepatocellular carcinoma (HCC). Despite evidence suggesting a link between adaptive immunity and HBV-related diseases in humans, the immunopathogenic mechanisms involved ...
Lu Zong, Hui Peng, Cheng-song Sun, Fenglei Li, M. Zheng, Yongyan Chen, Haiming Wei, R. Sun, Z. Tian   +8 more
semanticscholar   +1 more source

HDV can constrain HBV genetic evolution in hbsag: Implications for the identification of innovative pharmacological targets [PDF]

, 2018
Chronic HBV + HDV infection is associated with greater risk of liver fibrosis, earlier hepatic decompensation, and liver cirrhosis hepatocellular carcinoma compared to HBV mono-infection.
Andreoni, Massimo, Angelico, Mario, Barlattani, Angelo, Battisti, Arianna, Bertoli, Ada, Cappiello, Giuseppina, Carioti, Luca, Ceccherini-Silberstein, Francesca, Colagrossi, Luna, Coppola, Nicola, De Cristofaro, Maria, DE SANCTIS, Giuseppe Maria, Fabeni, Lavinia, Fleury, Hervé, Iapadre, Nerio, Lanza, Alfonso Galeota, Lenci, Ilaria, Lichtner, Miriam, Malagnino, Vincenzo, Mari, Terenzio, Marignani, Massimo, Mastroianni, Claudio, Minichini, Carmine, Nebuloso, Elena, Pasquazzi, Caterina, Perno, Carlo-Federico, Piermatteo, Lorenzo, Salpini, Romina, Sarmati, Loredana, Scutari, Rossana, Spanò, Alberto, Stanzione, Maria, Stornaiuolo, Gianfranca, Svicher, Valentina, Trimoulet, Pascale   +34 more
core   +2 more sources