Results 21 to 30 of about 3,494,763 (310)
DOCKGROUND Membrane Protein-Protein Set [PDF]
PLOS ONE, 2021 ABSTRACTMembrane proteins play essential role in cellular mechanisms. Despite that and the major progress in experimental structure determination, they are still significantly underrepresented in Protein Data Bank. Thus, computational approaches to protein structure determination, which are important in general, are especially valuable in the case of ...
Ian Kotthoff +2 more
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Polymer-encased nanodiscs with improved buffer compatibility
Scientific Reports, 2017 Styrene-maleic acid copolymers allow for solubilization and reconstitution of membrane proteins into nanodiscs. These polymer-encased nanodiscs are promising platforms for studies of membrane proteins in a near-physiologic environment without the use of ...
Mariana C. Fiori +3 more
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Cells, 2021 Zinc constitutes the second most abundant transition metal in the human body, and it is implicated in numerous cellular processes, including cell division, DNA and protein synthesis as well as for the catalytic activity of many enzymes.
Eva Ramos Becares +3 more
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Membrane protein secretases [PDF]
Biochemical Journal, 1997 A diverse range of membrane proteins of Type I or Type II topology also occur as a circulating, soluble form. These soluble forms are often derived from the membrane form by proteolysis by a group of enzymes referred to collectively as ‘secretases‘ or ‘sheddases’.
N M, Hooper, E H, Karran, A J, Turner
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Substrate-induced conformational dynamics of the dopamine transporter
Nature Communications, 2019 The dopamine transporter is responsible for termination of neurotransmission through Na+-driven reuptake of neurotransmitter from the extracellular space. Here authors use hydrogen-deuterium exchange mass spectrometry to monitor Na+- and dopamine-induced
Anne Kathrine Nielsen +6 more
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Structure and function of H+/K+ pump mutants reveal Na+/K+ pump mechanisms
Nature Communications, 2022 Here, the authors study ion transport mechanisms by introducing mutations to convert an electroneutral proton/potassium pump into a prototypical electrogenic sodium/potassium pump, explaining their selectivity and phosphorylation mechanisms.
Victoria C. Young +6 more
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Membrane-bending proteins [PDF]
Critical Reviews in Biochemistry and Molecular Biology, 2009 Cellular membranes can assume a number of highly dynamic shapes. Many cellular processes also require transient membrane deformations. Membrane shape is determined by the complex interactions of proteins and lipids. A number of families of proteins that directly bend membranes have been identified.
William A, Prinz, Jenny E, Hinshaw
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Membrane protein serendipity [PDF]
Journal of Biological Chemistry, 2018 My scientific career has taken me from chemistry, via theoretical physics and bioinformatics, to molecular biology and even structural biology. Along the way, serendipity led me to work on problems such as the identification of signal peptides that direct protein trafficking, membrane protein biogenesis, and cotranslational protein folding.
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Membrane-mediated protein interactions drive membrane protein organization
Nature Communications, 2022 AbstractThe plasma membrane’s main constituents, i.e., phospholipids and membrane proteins, are known to be organized in lipid-protein functional domains and supercomplexes. No active membrane-intrinsic process is known to establish membrane organization.
Yining Jiang +6 more
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Functional implications of the exon 9 splice insert in GluK1 kainate receptors
eLifeKainate receptors are key modulators of synaptic transmission and plasticity in the central nervous system. Different kainate receptor isoforms with distinct spatiotemporal expressions have been identified in the brain.
Surbhi Dhingra +3 more
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