Results 21 to 30 of about 13,149 (197)

Safety, tolerability, pharmacokinetics and pharmacodynamics of HSK31858, a novel oral dipeptidyl peptidase‐1 inhibitor, in healthy volunteers: An integrated phase 1, randomized, double‐blind, placebo‐controlled, single‐ and multiple‐ascending dose study

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Dipeptidyl peptidase‐1 (DPP‐1) inhibitors have been studied for the treatment of neutrophil‐mediated inflammatory diseases including bronchiectasis, bronchial asthma and cystic fibrosis. This study evaluated the pharmacokinetics, pharmacodynamics, safety and tolerability of DPP‐1 inhibitor HSK31858 in healthy Chinese volunteers.
Yuhao Wang, Chao Yu, Mengyue Hu, Lu Wang, Meixia Chen, Hanmo Liu, Nan Wu, Jie Hou   +7 more
wiley   +1 more source

The potential of deep learning in improving K‐12 students' writing skills: A systematic review

British Educational Research Journal, EarlyView.
Abstract The purpose of this study is to examine the relationship between technology‐supported writing instruction at the K‐12 level and deep learning approaches and to understand the trends in this field. In the study, 12 articles selected from Web of Science, Scopus, ERIC and EBSCO databases were systematically analysed.
Mazhar Bal, Emre Öztürk
wiley   +1 more source

Beyond the ‘dilemma of difference’: An analysis of stories from experienced teachers, about their inclusive practice

British Educational Research Journal, EarlyView.
Abstract Efforts to strengthen inclusive practice in education have been found to be underpinned by encounters with dilemmas. In particular, much has been written about the ‘dilemma of difference’, which is the perceived tension between wanting to provide for individual needs in education and wanting to avoid stigmatising individuals by treating them ...
Tracy Edwards
wiley   +1 more source

Fifty years of research on the Joulters ooid sandbody—Impact on carbonate sedimentology and diagenesis and lessons learned from an invaluable analogue

The Depositional Record, EarlyView.
The Joulters ooid sandbody of northern Great Bahama Bank is a vast expanse of muddy ooid sands partly rimmed by clean ooid sands and formed into a relatively thick layer of significant extent. Knowledge of the development of depositional and diagenetic patterns in the Joulters example has forwarded our general understanding of carbonate sedimentology ...
Harris Paul
wiley   +1 more source

The first 25 years of satellite carbonate sedimentology: What have we learned?

The Depositional Record, EarlyView.
Observations of the suspension and transport of carbonate sediments from reefs, banks and shallow shelves have been made by satellite instruments for ca 25 years. With an increasing number of instruments in space, providing advanced observational capabilities, remarkable insights have been gained concerning carbonate sedimentological processes. Details
James G. Acker, R. Jude Wilber
wiley   +1 more source

Maze‐Out: A Serious Game to Enhance Treatment for Eating Disorders. A Randomized Controlled Trial

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective This study evaluated the effectiveness of Maze Out, a serious game (SG) codesigned by patients with eating disorders (ED) and clinicians as an adjunct to treatment as usual (TAU) for improving self‐efficacy, self‐image, and engagement in individuals with ED.
Maria Mercedes Guala, Aida Bikic, Kim Bul, David Clinton, Anna Mejdal, Helene Nygaard Nielsen, René Klinkby Støving, Anette Søgaard Nielsen   +7 more
wiley   +1 more source

Acoustic features are independently associated with heart failure and pulmonary hypertension

ESC Heart Failure, EarlyView.
Abstract Introduction Acoustic analysis of speech has discriminated decompensated acute heart failure (HF). Speech rate (SR) and cepstral peak prominence (CPP) variation are among features previously evaluated. However, the association between SR and CPP and chronic stable HF with and without pulmonary hypertension (PH) as well as PH alone have not ...
Jaskanwal Deep S. Sara, Keiko Ishikawa, Yan Li, D.M. Anisuzzaman, Lilach O. Lerman, Amir Lerman, Diana Orbelo   +6 more
wiley   +1 more source

Family therapy for emerging adults with anorexia nervosa: Expert opinion on evidence, practice considerations, and future directions

European Eating Disorders Review, EarlyView.
Abstract Various forms of eating disorder focused family therapy (FT‐ED) have been developed and evaluated for adolescents. FT‐ED for adolescent anorexia nervosa (AN) focuses on empowering parents/carers with the knowledge and skills required to facilitate recovery for their child.
Elizabeth Dodge, Julian Baudinet, Amelia Austin, Ivan Eisler, Daniel Le Grange, Gina Dimitropoulos   +5 more
wiley   +1 more source

Sputum Microbiota Compositions Correlate With Metabolome and Clinical Outcomes of COPD‐Bronchiectasis Association: A Prospective Cohort Study

Exploration, EarlyView.
This study aimed to determine how microbiota compositions (via 16S rRNA sequencing) correlate with clinical outcome and metabolome (via liquid chromatography/mass spectrometry) of CBA. Sputum microbiome and metabolome profiles of CBA were well separated from COPD but not bronchiectasis, partly driven by the higher abundance of Proteobacteria in CBA ...
Zhen‐feng He, Xiao‐xian Zhang, Cui‐xia Pan, Xin‐zhu Yi, Yan Huang, Chun‐lan Chen, Shan‐shan Zha, Lai‐jian Cen, Han‐qin Cai, Lei Yang, Jia‐qi Gao, Hui‐min Li, Zhen‐hong Lin, Sheng‐zhu Lin, Zhang Wang, Nan‐shan Zhong, Wei‐jie Guan   +16 more
wiley   +1 more source

Reimagining higher education: The impact of learner outcome metrics in Ireland and beyond

Future in Educational Research, EarlyView.
Abstract A college is an institution that exists to provide instruction. Subtly but profoundly, we are shifting to a new paradigm: a college is an institution that exists to produce learning (Barr & Tagg, 1995, p. 13). This paper traces the evolution of learner outcomes, from their progeny as a diagnostic tool in accurately measuring learning gains and
Gerry Dunne
wiley   +1 more source