Results 21 to 30 of about 1,351,970 (298)

Epigenetic Dysregulation of the Homeobox A5 (HOXA5) Gene Associates with Subcutaneous Adipocyte Hypertrophy in Human Obesity

open access: yesCells, 2022
Along with insulin resistance and increased risk of type 2 diabetes (T2D), lean first-degree relatives of T2D subjects (FDR) feature impaired adipogenesis in subcutaneous adipose tissue (SAT) and subcutaneous adipocyte hypertrophy well before diabetes ...
Luca Parrillo   +12 more
doaj   +1 more source

Antibody CDR amino acids underlying the functionality of antibody repertoires in recognizing diverse protein antigens

open access: yesScientific Reports, 2022
Antibodies recognize protein antigens with exquisite specificity in a complex aqueous environment, where interfacial waters are an integral part of the antibody–protein complex interfaces.
Hung-Pin Peng   +8 more
doaj   +1 more source

Recent advances in aptamer-based targeted drug delivery systems for cancer therapy

open access: yesFrontiers in Bioengineering and Biotechnology, 2022
The past decade has become an important strategy in precision medicine for the targeted therapy of many diseases, expecially various types of cancer. As a promising targeted element, nucleic acid aptamers are single-stranded functional oligonucleotides ...
Fei Gao   +5 more
doaj   +1 more source

The Impact of Translating English Haiku on the Emergence of Haiku in Persian Literature [PDF]

open access: yesمطالعات بین‌رشته‌ای ادبیات، هنر و علوم انسانی
This study aims to conduct a comparative analysis of translated English haikus and Iranian haikus, exploring whether Persian haikus (composed in Persian) exhibit literary characteristics influenced by translated haikus or possess distinct traits. To this
Fatemeh Parham, Meead Jahantigh
doaj   +1 more source

Safety of pharmacologic interventions for neuropsychiatric symptoms in dementia: a systematic review and network meta-analysis

open access: yesBMC Geriatrics, 2020
Background Prescribing trends suggest that pharmacologic alternatives to antipsychotics are gaining in popularity, but randomized trial (RCT) data of their comparative safety is scarce.
Jennifer A. Watt   +10 more
doaj   +1 more source

Molecular Engineering of Polymyxin B for Imaging and Treatment of Bacterial Infections

open access: yesFrontiers in Chemistry, 2022
The emergence of multi-drug resistant bacteria and the lack of novel antibiotics to combat them have led to the revival of polymyxin B, a previously abandoned antibiotic due to its potential nephrotoxicity and neurotoxicity.
Minghao Wu   +5 more
doaj   +1 more source

Geographic variation in walking activity in the red flour beetle Tribolium castaneum

open access: yesPopulation Ecology, EarlyView.
This study examined whether there is geographic variation in field populations, focusing on the moving activity in the red flour beetle Tribolium castaneum. Results showed significant differences in moving activity among field populations but no correlation with latitude or meteorological factors.
Kentarou Matsumura
wiley   +1 more source

E-COMMERCE CONNECTING CHINA AND LATIN AMERICA VIA DIGITAL SILK-ROAD

open access: yesRevista Cubana de Administración Pública y Empresarial, 2022
Latin America is the natural extension of the “Maritime Silk Road” and its exchanges and cooperation with China have become increasingly frequent in recent years.
Xiaoyu Li   +4 more
doaj   +1 more source

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

open access: yesFEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali   +3 more
wiley   +1 more source

Translation and Translational Control in Dinoflagellates [PDF]

open access: yesMicroorganisms, 2018
Dinoflagellates are unicellular protists that feature a multitude of unusual nuclear features, including large genomes, packaging of DNA without histones, and multiple gene copies organized as tandem gene arrays. Furthermore, all dinoflagellate mRNAs experience trans-splicing with a common 22-nucleotide splice leader (SL) sequence.
Sougata Roy, Rosemary Jagus, David Morse
openaire   +4 more sources

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