Results 31 to 40 of about 673,332 (240)

A novel binding site between the voltage-dependent calcium channel CaV1.2 subunit and CaVβ2 subunit discovered using a new analysis method for protein–protein interactions

Scientific Reports, 2023
We developed a new method to analyze protein–protein interactions using a dual-inducible prokaryotic expression system. To evaluate protein–protein binding, a chimeric fusion toxin gene was constructed using a DNase-treated short DNA fragment (epitope ...
Agnieszka M. Murakami, Katsuhiro Nagatomo, Ichro Miyoshi, Shirou Itagaki, Yasutaka Niwa, Manabu Murakami   +5 more
doaj   +1 more source

Primary Structure and Conformation of a Tetrodotoxin-Binding Protein in the Hemolymph of Non-Toxic Shore Crab Hemigrapsus sanguineus

Journal of Marine Science and Engineering, 2023
Tetrodotoxin (TTX)-binding proteins are present in toxic TTX-bearing animals, such as pufferfish and gastropods. These may prevent autotoxicity. However, TTX-binding proteins are also found in the nontoxic marine shore crab, Hemigrapsus sanguineus. Here,
Yuji Nagashima, Kenta Fujimoto, Masahiko Okai, Yoichiro Kitani, Aya Yoshinaga-Kiriake, Shoichiro Ishizaki   +5 more
doaj   +1 more source

Cholesterol down-regulates BK channels stably expressed in HEK 293 cells. [PDF]

PLoS ONE, 2013
Cholesterol is one of the major lipid components of the plasma membrane in mammalian cells and is involved in the regulation of a number of ion channels.
Wei Wu, Yan Wang, Xiu-Ling Deng, Hai-Ying Sun, Gui-Rong Li   +4 more
doaj   +1 more source

Bioenergetic Consequences of FLAG Tag Addition to the C-Terminus of Subunit 8 of Yeast Saccharomyces cerevisiae Mitochondrial ATP Synthase

Hayati Journal of Biosciences, 2010
The yeast mitochondrial F1F0-ATP synthase is a multisubunit complex that contains at least 17 different subunits. Subunit 8 of yeast mitochondrial ATP synthase is a hydrophobic protein of 48 amino acids encoded by the mitochondrial ATP8 gene.
I MADE ARTIKA
doaj   +3 more sources

A Subunit Vaccine Based on E2 Protein of Atypical Porcine Pestivirus Induces Th2-type Immune Response in Mice

Viruses, 2018
An atypical porcine pestivirus (APPV) causing congenital tremor type A-II in piglets was identified in China in 2016. An increased number of cases of APPV have been reported in various countries all over the world since 2015.
Huawei Zhang, Wei Wen, Genxi Hao, Huanchun Chen, Ping Qian, Xiangmin Li   +5 more
doaj   +1 more source

Protein Kinase A Regulatory Subunits in Colon Cancer

Neoplasia: An International Journal for Oncology Research, 1999
The protein kinase A (PKA) is classified as type I or II depending on the association of the catalytic subunit with either the RI or RII regulatory subunits.
Chris C. Carlson, Stacy L. Smithers, Karen A. Yeh, Laura L. Burnham, Daniel T. Dransfield   +4 more
doaj   +1 more source

Generation of active protein phosphatase 2A is coupled to holoenzyme assembly. [PDF]

PLoS Biology, 2007
Protein phosphatase 2A (PP2A) is a prime example of the multisubunit architecture of protein serine/threonine phosphatases. Until substrate-specific PP2A holoenzymes assemble, a constitutively active, but nonspecific, catalytic C subunit would constitute
Hans Hombauer, David Weismann, Ingrid Mudrak, Claudia Stanzel, Thomas Fellner, Daniel H Lackner, Egon Ogris   +6 more
doaj   +1 more source

Epigallocatechin gallate restores the reduction of protein phosphatase 2 A subunit B caused by middle cerebral artery occlusion

Laboratory Animal Research, 2023
Background Epigallocatechin gallate (EGCG) is a flavonoid compound commonly found in green tea. It exhibits antioxidant, anti-inflammatory, and neuroprotective effects in cerebral ischemia.
Murad-Ali Shah, Ju-Bin Kang, Dong-Ju Park, Phil Ok Koh   +3 more
doaj   +1 more source

Analytical Insights into Protein–Alum Interactions and Their Impact on Conformational Epitope

Pharmaceutics
Several alum-adjuvanted vaccines have been licensed in the past 40 years. Despite its extensive and continuous use, the immune mechanism of action of alum adjuvants is not yet completely understood. Many different variables during the formulation process
Alessio Corrado, Mila Toppazzini, Alessandro Vadi, Carmine Malzone, Rosy Galasso, Alessandro Donati, Riccardo De Ricco, Francesco Berti   +7 more
doaj   +1 more source

TRAF2 Is a Novel Ubiquitin E3 Ligase for the Na,K-ATPase β-Subunit That Drives Alveolar Epithelial Dysfunction in Hypercapnia

Frontiers in Cell and Developmental Biology, 2021
Several acute and chronic lung diseases are associated with alveolar hypoventilation leading to accumulation of CO2 (hypercapnia). The β-subunit of the Na,K-ATPase plays a pivotal role in maintaining epithelial integrity by functioning as a cell adhesion
Nieves M. Gabrielli, Luciana C. Mazzocchi, Vitalii Kryvenko, Vitalii Kryvenko, Khodr Tello, Khodr Tello, Susanne Herold, Susanne Herold, Rory E. Morty, Rory E. Morty, Rory E. Morty, Friedrich Grimminger, Friedrich Grimminger, Friedrich Grimminger, Laura A. Dada, Werner Seeger, Werner Seeger, Werner Seeger, Werner Seeger, Jacob I. Sznajder, István Vadász, István Vadász   +21 more
doaj   +1 more source