Results 41 to 50 of about 432,537 (413)

A Hydrophobic Gate in an Ion Channel: The Closed State of the Nicotinic Acetylcholine Receptor [PDF]

Physical Biology, 3(2):147-159, 2006, 2005
The nicotinic acetylcholine receptor (nAChR) is the prototypic member of the `Cys-loop' superfamily of ligand-gated ion channels which mediate synaptic neurotransmission, and whose other members include receptors for glycine, gamma-aminobutyric acid, and serotonin.
arxiv   +1 more source

Cholinergic Pathway SNPs and Postural Control in 477 Older Adults

Frontiers in Aging Neuroscience, 2018
Objective: To determine whether single nucleotide polymorphisms (SNPs) of the cholinergic system and quantitative parameters of postural control are associated in healthy older adults.
Carina Arnold, Carina Arnold, Claudia Schulte, Claudia Schulte, Mariana Moscovich, Ulrike Sünkel, Ulrike Sünkel, Laura Zaunbrecher, Laura Zaunbrecher, Florian Metzger, Florian Metzger, Thomas Gasser, Thomas Gasser, Gerhard W. Eschweiler, Gerhard W. Eschweiler, Ann-Kathrin Hauser, Ann-Kathrin Hauser, Daniela Berg, Daniela Berg, Daniela Berg, Walter Maetzler, Walter Maetzler, Walter Maetzler   +22 more
doaj   +1 more source

Loss of GABA co-transmission from cholinergic neurons impairs behaviors related to hippocampal, striatal, and medial prefrontal cortex functions

Frontiers in Behavioral Neuroscience, 2022
Introduction: Altered signaling or function of acetylcholine (ACh) has been reported in various neurological diseases, including Alzheimer’s disease, Tourette syndrome, epilepsy among others.
R. Oliver Goral, R. Oliver Goral, Kathryn M. Harper, Briana J. Bernstein, Briana J. Bernstein, Sydney A. Fry, Sydney A. Fry, Patricia W. Lamb, Sheryl S. Moy, Jesse D. Cushman, Jesse D. Cushman, Jerrel L. Yakel   +11 more
doaj   +1 more source

Case report: Immune remission from generalized myasthenia gravis in a dog with a thymoma and cholangiocellular carcinoma

Frontiers in Veterinary Science, 2023
A 9-year-old male neutered Cockapoo was presented with an acute and progressive history of exercise induced weakness involving all limbs, and bilateral decreased ability to blink.
Thomas Mignan, Thomas Mignan, Robert White, Kimberley Stee, Giuseppe Bonanno, Mike Targett, Mark Lowrie   +6 more
doaj   +1 more source

Acetylcholine and cholinergic receptors

Brain and Neuroscience Advances, 2019
This review provides a distillate of the advances in knowledge about the neurotransmitter functions of acetylcholine over the 50-year period between 1967 and 2017, together with incremental information about the cognate nicotinic and muscarinic ...
D. Brown
semanticscholar   +1 more source

A Microbioassay for Acetylcholine.

Experimental Biology and Medicine, 1961
SummaryA microbioassay for acetylcholine is described in which a solution containing acetylcholine is microperfused onto the endplate area of a chronically denervated skeletal muscle fiber. The endpoint, a brief tetanus, can be produced by application of as little as 0.15 μl of a solution which contains acetylcholine chloride at a concentration of 2.5 ×
William L. Nastuk, Leonard Levine
openaire   +3 more sources

NACHO Mediates Nicotinic Acetylcholine Receptor Function throughout the Brain

Cell Reports, 2017
Neuronal nicotinic acetylcholine receptors (nAChRs) participate in diverse aspects of brain function and mediate behavioral and addictive properties of nicotine.
Jose A. Matta, Shenyan Gu, Weston B. Davini, Brian Lord, Edward R. Siuda, Anthony W. Harrington, David S. Bredt   +6 more
doaj   +1 more source

Psychological stress induces an increase in cholinergic enteric neuromuscular pathways mediated by glucocorticoid receptors

Frontiers in Neuroscience, 2023
IntroductionRepeated acute stress (RASt) is known to be associated with gastrointestinal dysfunctions. However, the mechanisms underlying these effects have not yet been fully understood.
Justine Blin, Justine Blin, Camille Gautier, Philippe Aubert, Tony Durand, Thibauld Oullier, Laetitia Aymeric, Laetitia Aymeric, Philippe Naveilhan, Damien Masson, Damien Masson, Michel Neunlist, Kalyane Bach-Ngohou, Kalyane Bach-Ngohou   +13 more
doaj   +1 more source

A fast genetically encoded fluorescent sensor for faithful in vivo acetylcholine detection in mice, fish, worms and flies [PDF]

, 2020
Here we design and optimize a genetically encoded fluorescent indicator, iAChSnFR, for the ubiquitous neurotransmitter acetylcholine, based on a bacterial periplasmic binding protein.
Borden, Philip M., Fan, Chengcheng, Lester, Henry A., Rees, Douglas C., Shivange, Amol V.   +4 more
core  

Endogenous cholinergic inputs and local circuit mechanisms govern the phasic mesolimbic dopamine response to nicotine [PDF]

, 2013
Nicotine exerts its reinforcing action by stimulating nicotinic acetylcholine receptors (nAChRs) and boosting dopamine (DA) output from the ventral tegmental area (VTA).
A Taly, AA Grace, AJ Yu, AO Komendantov, AR Tapper, B Buisson, B Katz, Boris Gutkin, C Lüscher, C Shelley, CP Fenster, DB Carr, E Lichtenstein, E Sher, EJ Nestler, F Marti, FE Pontieri, G Di Chiara, G Di Chiara, G Di Chiara, GL Forster, HD Mansvelder, HD Mansvelder, HR Wilson, IW Jones, J Cornwall, J Grenhoff, JA Dani, Ja Dani, JB Eaton, JE Henningfield, JE Rose, JN Reynolds, JP Changeux, JP Changeux, JP Changeux, JR Clements, JR Wooltorton, K Chergui, Karl J. Friston, KG Paradiso, LE Chavez-Noriega, M Gao, M Garzón, M Graupner, M Mameli-Engvall, M Wu, MG Lacey, Michael Graupner, MJ Christie, MR Picciotto, MR Picciotto, N Champtiaux, P Dayan, PW Kalivas, R Exley, R Giniatullin, R Klink, R Nashmi, Reinoud Maex, RL Papke, S Erhardt, S Ikemoto, S Tolu, SA Oakman, SC Steffensen, SR Grady, SR Sesack, SW Johnson, SW Johnson, TC Jhou, V David, V Gerzanich, V Gerzanich, VI Pidoplichko, WA Corrigall, X Peng, ZM Fagen, ZY Tong   +78 more
core   +4 more sources