Results 41 to 50 of about 7,380 (205)

In Vitro Evaluation of CYP‐Mediated Metabolism of Fezolinetant and Pharmacokinetic Interaction Between Fezolinetant and Fluvoxamine in Healthy Postmenopausal Smokers and Nonsmokers

The Journal of Clinical Pharmacology, Volume 65, Issue 4, Page 508-519, April 2025.
Abstract Fezolinetant is an oral, nonhormonal, neurokinin 3 receptor antagonist treatment option for moderate to severe vasomotor symptoms associated with menopause. An in vitro study using human recombinant cytochrome P450 (CYP) enzymes and human liver microsomes showed that fezolinetant is metabolized to its major but inactive metabolite, ES259564 ...
Megumi Iwai, Jace Nielsen, Mayuko Miyagawa, Melanie Patton, Peter L. Bonate, Xuegong Wang, Tomasz Wojtkowski, Angela Sinn, Jiayin Huang   +8 more
wiley   +1 more source

Synthesis and Evaluation of Some New Isoquine Analogues for Antimalarial Activity

E-Journal of Chemistry, 2009
Amodiaquine is a 4-aminoquinoline antimalarial that can cause adverse side effects including hepatic and haematological toxicity. The drug toxicity involves the formation of an electrophilic metabolite, amodiaquine quinoneimine (AQQI), which binds to ...
Chandra Nath Saha, Sanjib Bhattacharya, Dipak Chetia   +2 more
doaj   +1 more source

Polimorfismos del gen pfmdr1 en muestras clínicas de Plasmodium falciparum y su relación con la respuesta terapéutica a antipalúdicos y paludismo grave en Colombia

Biomédica: revista del Instituto Nacional de Salud, 2007
Introducción. El gen pfmdr1 de Plasmodium falciparum se describió como un gen de resistencia a diversos antipalúdicos. Sin embargo, no se han estudiado el papel de su polimorfismo en la respuesta terapéutica al tratamiento con antipalúdicos en Colombia ...
Paula Montoya, Alberto Tobón, Silvia Blair, Jaime Carmona, Amanda Maestre   +4 more
doaj   +1 more source

PBPK‐Led Assessment of Antimalarial Drug Concentrations in Breastmilk: A Strategy for Optimal Use of Prediction Methods to Guide Decision Making in an Understudied Population

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 4, Page 738-750, April 2025.
ABSTRACT Treatment of breastfeeding mothers with malaria is challenging due to the lack of information describing drug exposure in milk and the daily dose to the breastfed infant. Physiologically based pharmacokinetic (PBPK) modeling was used to predict milk‐to‐plasma (M/P) ratios, infant daily doses (IDD) and relative infant doses (RID) for five ...
Lisa M. Almond, Khaled Abduljalil, Amita Pansari, Beata Kusmider, Hannah M. Jones, Karen Rowland Yeo, Iain Gardner, Muhammad Faisal, Anne Claire Marrast, Myriam El Gaaloul, Jörg J. Möhrle, Nada Abla   +11 more
wiley   +1 more source

Oral amodiaquine microparticles repurposed for the treatment of visceral leishmaniasis

Scientific African, 2022
Background: Leishmaniasis, a neglected tropical disease, is caused by parasites from the genus Leishmania and transmitted by the female phlebotamine sandfly.
Henry Nettey, Isaac Joe Erskine, Afia Antwi Mensah, Nana Kwame Ofori Gyamera, Charles Kwadwo Obuobi, Doris Kumadoh, Isaac Julius Asiedu-Gyekye, Grace Lovia Allotey-Babington   +7 more
doaj  

Gametocitemia en malaria por Plasmodium falciparum tratada con amodiaquina o artesunato

Biomédica: revista del Instituto Nacional de Salud, 2008
Introducción. Las relaciones de la gametocitemia de Plasmodium falciparum con el tratamiento antipalúdico han sido poco estudiadas en América. Objetivo.
Jaime Carmona-Fonseca, Eliana Arango, Silvia Blair   +2 more
doaj   +1 more source

Use of population pharmacokinetic‐pharmacodynamic modelling to inform antimalarial dose optimization in infants

British Journal of Clinical Pharmacology, Volume 91, Issue 4, Page 968-980, April 2025.
Infants bear a significant malaria burden but are usually excluded from participating in early dose optimization studies that inform dosing regimens of antimalarial therapy. Unlike older children, infants' exclusion from early‐phase trials has resulted in limited evidence to guide accurate dosing of antimalarial treatment for uncomplicated malaria or ...
Clifford G. Banda, Joel Tarning, Karen I. Barnes   +2 more
wiley   +1 more source

Eficacia de la combinación amodiaquina más sulfadoxinapirimetamina y de la cloroquina para el tratamiento del paludismo en Córdoba, Colombia, 2006

Biomédica: revista del Instituto Nacional de Salud, 2008
Introducción. La disminución de la eficacia de los medicamentos antipalúdicos en el mundo y en Colombia, dificulta el control de la enfermedad. Objetivo.
Manuel Alberto Pérez, Liliana Jazmín Cortés, Ángela Patricia Guerra, Angélica Knudson, Carlos Usta, Rubén Santiago Nicholls   +5 more
doaj   +1 more source

Pharmacokinetics of a Novel Piperaquine Dispersible Granules Formulation Under Fasting and Various Fed Conditions Versus Piperaquine Tablets When Fasted in Healthy Tanzanian Adults: A Randomized, Phase I Study

Clinical and Translational Science, Volume 18, Issue 2, February 2025.
ABSTRACT Piperaquine tetraphosphate (PQP), a long‐acting antimalarial, is being considered in a combination for chemoprevention. Dihydroartemisinin‐piperaquine tablets (hard and dispersible) approved for the treatment of acute uncomplicated malaria should be administered in a fasted state, as PQP bioavailability increases with food.
Florence A. Milando, Said Jongo, Salim Abdulla, Gloria Nyaulingo, Anneth‐Mwasi Tumbo, Sarah Mswata, Juliether Tiago, Beatus S. Bongole, Ashura Mirambo, Kamaka Kassimu, Hussein Mbarak, Mohammed A. Rashid, Ali Hamad, Michael Mihayo, Tunu Ndanzi, Omary Zuberi, Naima Saadia, Mariam Somboka, Mariam Yamba‐Yamba, Theresia Ngonyani, Amina Nditi, Margaret Msuya, Bakari Mwalimu, Hajirani M. Msuya, Khamis Awadh, Ali Ali, Anne Claire Marrast, Denis Gossen, Alice Neequaye, Myriam El‐Gaaloul, Hanu Ramachandruni, Isabelle Borghini‐Fuhrer   +31 more
wiley   +1 more source

Plasmodium falciparum genetic factors rather than host factors are likely to drive resistance to ACT in Ghana

Malaria Journal, 2020
Background Artemisinin-based combination therapy (ACT) partner drugs, currently used in Ghana are lumefantrine, amodiaquine and piperaquine. Plasmodium falciparum isolates with reduced susceptibility to these partner drugs may affect treatment outcome ...
Peter Hodoameda, Nancy Odurowah Duah-Quashie, Charles Oheneba Hagan, Sena Matrevi, Benjamin Abuaku, Kwadwo Koram, Neils Ben Quashie   +6 more
doaj   +1 more source