Recent Advances in the Therapeutic Efficacy of Artesunate
Pharmaceutics, 2022 Artesunate, a semisynthetic artemisinin derivative, is well-known and used as the first-line drug for treating malaria. Apart from treating malaria, artesunate has also been found to have biological activity against a variety of cancers and viruses.
Blessing A Aderibigbe
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Preparations of Rectal Suppositories Containing Artesunate
Pharmaceutics, 2020 Rectal artesunate suppositories are a useful option for pre-referral treatment of severe malaria, specifically in children under 6 years of age in remote malaria-endemic areas.
Hyunah Cho
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Artesunate nanoliposomes in hepatocellular carcinoma: mechanistic ferroptosis induction and translational opportunities [PDF]
Discover OncologyArtesunate nanoliposomes are lipid-based nanoscale vesicles encapsulating the antimalarial agent artesunate, which have shown potential to suppress hepatocellular carcinoma (HCC) growth and metastasis by modulating ferroptosis-related pathways.
Chunxia Zhao +7 more
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EBioMedicine, 2015 Background: Artesunate is an antimalarial agent with broad anti-cancer activity in in vitro and animal experiments and case reports. Artesunate has not been studied in rigorous clinical trials for anticancer effects.
Sanjeev Krishna +2 more
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Possible mechanisms of the hypoglycaemic effect of artesunate: Gender implication
Metabolism Open, 2021 Background: We investigated the mechanism of artesunate’s glucose-modulating effect especially with gender implication. Methods: Twenty-five (25) male and 25 female rats were separately and blindly allocated into five identical groups (n = 5/group ...
Abdullateef Isiaka Alagbonsi +4 more
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YM155, specific survivin inhibitor, can enhance artesunate-induced cytotoxicity in HCT116 colon cancer cells [PDF]
Korean Journal of Clinical Oncology, 2020 Purpose A water-soluble variant of the artemisinin called artesunate, approved as an antimalarial agent, can induce cell death on various cancer cell types. We studied the mechanism of cell death of artesunate on HCT116 colorectal cancer cells.
Eui Tae Kim, Dong-Guk Park
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Preclinical Evaluation of Artesunate as an Antineoplastic Agent in Ovarian Cancer Treatment
Diagnostics, 2021 Background: Ovarian cancer is the deadliest gynecologic malignancy despite current first-line treatment with a platinum and taxane doublet. Artesunate has broad antineoplastic properties but has not been investigated in combination with carboplatin and ...
Anthony McDowell +7 more
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Artesunate abolishes germinal center B cells and inhibits autoimmune arthritis. [PDF]
PLoS ONE, 2014 The antimalarial drug artemisinin and its derivatives exhibit potent immunosuppressive activity in several autoimmune disease models, however the mechanisms are not well-understood.
Lifei Hou +2 more
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Role of transferrin receptor and the ABC transporters ABCB6 and ABCB7 for resistance and differentiation of tumor cells towards artesunate. [PDF]
PLoS ONE, 2007 The anti-malarial artesunate also exerts profound anti-cancer activity. The susceptibility of tumor cells to artesunate can be enhanced by ferrous iron.
Gerhard Kelter +6 more
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Frontiers in Pharmacology, 2020 Objective: The purpose of this meta-analysis of longitudinal studies is to determine the safety and efficacy of artesunate combined with other forms of adjunctive therapies for severe malaria.Methods: Following the PRISMA guidelines, we searched multiple
Yuanyuan Zou +18 more
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