Results 41 to 50 of about 26,165 (195)

Sulfadoxine-pyrimethamine–based combinations for malaria : a randomised blinded trial to compare efficacy, safety and selection of resistance in Malawi [PDF]

, 2008
Background: In Malawi, there has been a return of Plasmodium falciparum sensitivity to chloroquine (CQ) since sulfadoxinepyrimethamine (SP) replaced CQ as first line treatment for uncomplicated malaria.
David J. Bell, Suzgo K. Nyirongo, Mavuto Mukaka, Ed E. Zijlstra, Christopher V. Plowe, Malcolm E. Molyneux, Steve A. Ward, Peter A. Winstanley, Aric Gregson, CV Plowe, MK Laufer, P Olumese, CO Obonyo, P Brasseur, AF Gasasira, CS Hatton, KA Neftel, P Olliaro, AA Djimde, JG Kublin, CV Plowe, A Cattamanchi, JG Kublin, TO Abuya, SR Hawley, G Dorsey, CE Rwagacondo, WM Watkins, CT Happi, GS Humphreys, SL Nsobya, I Zongo, C Dokomajilar, C Sisowath, MT Duraisingh, AP Alker, PA Phillips-Howard, D Douer, R Carr, EG Rhodes, ME Ellis   +40 more
core   +7 more sources

Protectiveness of Artesunate Given Prior Ischemic Cerebral Infarction Is Mediated by Increased Autophagy

Frontiers in Neurology, 2018
Background: Ischemic cerebral infarction is a severe clinical condition that can cause serious mortality. Artesunate, an anti-malarial drug that is widely used in cancer treatment, is known to facilitate accelerated cell apoptosis.
Ming Shao, Yue Shen, Hongjing Sun, Delong Meng, Wei Huo, Xu Qi   +5 more
doaj   +1 more source

Genetic and genomic approaches for the discovery of parasite genes involved in antimalarial drug resistance [PDF]

, 2013
The biggest threat to the war on malaria is the continued evolution of drug resistance by the parasite. Resistance to almost all currently available antimalarials now exists in Plasmodium falciparum which causes the most suffering among all human malaria
Mwangi, J.M., Ranford-Cartwright, L.C.
core   +1 more source

Theranostic nanoplatform for high‐performance dual‐modal magnetic resonance imaging‐guided therapy of orthotopic hepatocellular carcinoma

BMEMat, EarlyView.
This article introduces a biomimetic Mn‐doped polydopamine nanoplatform (HAMM NPs) coated with cancer cell membranes. It enables targeted hepatocellular carcinoma theranostics via T1/T2 dual‐mode magnetic resonance imaging and tumor microenvironment‐triggered sonodynamic therapy/chemodynamic therapy, achieving potent antitumor efficacy in subcutaneous ...
Jiayin Lin, Wenbo Chen, Xiuqi Hou, Kai Wang, Fan Liu, Ruling Zhang, Zhong Cao, Jian Zheng   +7 more
wiley   +1 more source

Pyronaridine–artesunate and artemether–lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in Kenyan children: a randomized controlled non-inferiority trial

Malaria Journal, 2018
Background Pyronaridine–artesunate is a novel artemisinin-based combination therapy. The efficacy and safety of pyronaridine–artesunate were compared with artemether–lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in ...
Johanna M. Roth, Patrick Sawa, Nicodemus Makio, George Omweri, Victor Osoti, Selpha Okach, Felix Choy, Henk D. F. H. Schallig, Pètra Mens   +8 more
doaj   +1 more source

Repurposing Drugs for Malaria through a Human Dose Prediction: A Case Study with Berzosertib

Clinical Pharmacology &Therapeutics, EarlyView.
Repurposing drugs whose clinical safety has been established offers a valuable approach to reduce the cost and time associated with the development of new drugs for malaria. Here, we investigate the potential to repurpose the anticancer kinase inhibitor berzosertib for the treatment of malaria, by assessing whether a predicted efficacious human dose ...
Devasha Redhi, Mwila Mulubwa, Mmakwena M. Mmonwa, Mathew Njoroge, Liezl Krugmann, Kelly Chibale   +5 more
wiley   +1 more source

Incidence and outcomes of childhood status epilepticus in Kano, northern Nigeria

Epilepsia Open, EarlyView.
Abstract Objective Convulsive status epilepticus (CSE) is a major neurological emergency in childhood, but population‐based data from low‐ and middle‐income countries remain limited. We estimated the incidence, mortality, neurological outcomes, and predictors of adverse outcomes among children with CSE in Kano, northern Nigeria.
Umar A. Sabo, Halima Kabir, Aminu T. Abdullahi, Halima Adamu, Auwal S. Salihu, Abba M. Abdullahi, Aminu Wada, Zubairu Iliyasu, Jamilu Zakari, Safiya Gambo, Binta W. Jibir, Muktar H. Aliyu, Usman J. Wudil, Donna J. Ingles, Heather L. Prigmore, Bryan E. Shepherd, Angela R. Paolucci, Edwin Trevathan   +17 more
wiley   +1 more source

The Antifungal Activity of Artesunate toward Candida albicans: Two Opposite Activities

Microbiology Indonesia, 2020
The artemisinin and its derivatives antifungal activity continue to be an interesting research object, with the potential shown to be developed as an antifungal compound.
MOHAMMAD RIZKI F ADHIL PRATAMA, DARYONO HADI TJAHJONO, TUTUS GUSDINAR   +2 more
doaj   +1 more source

Efficacy and Safety of Anal High‐Grade Squamous Intraepithelial Lesion Treatment Modalities: A Systematic Review

ANZ Journal of Surgery, EarlyView.
ABSTRACT Background There is compelling evidence that treating high‐grade squamous intraepithelial lesions (HSIL), the anal squamous cell cancer (ASCC) precursor, reduces the risk of developing ASCC. Using high‐resolution anoscopy (HRA), surgical excision, ablative and topical therapies are widely used to treat HSIL.
Matthew Joseph Marino, Sophie Jones, Nicholas Reid Caldwell, Catherine Cartwright, Benedict Blacket, Richard Clive Turner   +5 more
wiley   +1 more source

First use of intravenous artesunate in Liberia and effect on patient mortality relative to artemeter and quinine: a cross-sectional study

The Lancet Global Health, 2014
Background: Intravenous artesunate reduces mortality by 35% relative to intravenous quinine. In 2010, WHO changed guidelines favouring intravenous artesunate, yet wide-scale adoption lags.
Dr. Wilson Wang, MD, Augustine Koryon, BS, Bernice Dahn, MD   +2 more
doaj   +1 more source