Results 41 to 50 of about 17,074 (196)

Trends in malaria morbidity following the introduction of artesunate plus amodiaquine combination in M'lomp village dispensary, south-western Senegal. [PDF]

, 2008
BACKGROUND: In Thailand, South Africa and Zanzibar, a decrease in malaria morbidity was observed following the introduction of artemisinin-based combination therapy (ACT).
Senghor Paul, Sophie Sarrassat, Le Hesran, Jean Yves, Paul Senghor, Hesran Jean, Le Hesran, Jean-Yves, Senghor, Paul, Jean Yves Le Hesran, Sophie SophieSarrassat, Sarrassat, Sophie, Sarrassat Sophie, Jean Hesran   +11 more
core   +1 more source

Prevention of plant crown gall tumor development by the anti-malarial artesunate of Artemisia annua

Journal für Kulturpflanzen, 2009
The antimalarial drug artesunate, a sesquiterpene trioxane lactone derivative of artemisinin from Artemisia annua L., is known for its extraordinary inhibitory effects on plasmodia and trematodes and also for suppressing the proliferation of human tumor ...
Cornelia I. Ullrich, Monika von Eitzen-Ritter, Annemarie Jockel, Thomas Efferth   +3 more
doaj   +1 more source

Artesunate Inhibits the Development of Esophageal Cancer by Targeting HK1 to Reduce Glycolysis Levels in Areas With Zinc Deficiency

Frontiers in Oncology, 2022
Esophageal cancer (EC) threatens many lives in China, especially in areas with high incidences of EC. Our previous studies proved that zinc deficiency (ZD) promotes the cell cycle, thus promoting the progression of EC in areas with a high incidence of EC.
Jing Jin, Dongli Guo, Yingying Wang, Wenpeng Jiao, Daojuan Li, Yutong He   +5 more
doaj   +1 more source

Artemisinins [PDF]

, 2005
Artemisinins were discovered to be highly effective antimalarial drugs shortly after the isolation of the parent artemisinin in 1971 in China. These compounds combine potent, rapid antimalarial activity with a wide therapeutic index and an absence of ...
C J Woodrow, S Krishna, Woodrow, C. J., Haynes, R. K., Woodrow, CJ, Krishna, S., Haynes, RK, Krishna, S, R K Haynes   +8 more
core   +1 more source

Biological measure of compliance to Artesunate plus Amodiaquine association: interest in a Mono-Desethyl-Amodiaquine blood assay? [PDF]

, 2009
The deployment of Artemisinin-based Combination Therapy for treating uncomplicated malaria poses problems in the patient compliance to these new treatments.
Le Hesran, Jean Yves, Le Hesran, Jean-Yves, Sakho, M., Sakho, Madiagne, Sarrassat, Sophie   +4 more
core   +1 more source

Spectrophotometric analysis of artesunate injections available in community pharmacies in Northern and Western Uganda

Future Science OA
Aim The surge in different brands of artesunate injection in Uganda, has raised the need for this study, which aimed at quantifying the actual amount of artesunate in different brands of artesunate injections available in Northern and Western Uganda ...
Ebere Emilia Ayogu, Emmanuel Aryon Ngolryeko, Joseph Obiezu Chukwujekwu Ezeonwumelu, Ibrahim Garba Wawata, Bashir Olaniyi Sadiq   +4 more
doaj   +1 more source

Pharmacometric evaluation of pre‐referral rectal artesunate in children with severe malaria

British Journal of Clinical Pharmacology, EarlyView.
Aims Parenteral artesunate is the preferred first‐line treatment for severe malaria. Pre‐referral rectal artesunate suppositories are recommended where parenteral treatment is inaccessible. In this study, we compared dihydroartemisinin exposure and model‐predicted early parasite clearance following rectal artesunate and intravenous artesunate in ...
Ayorinde Adehin, Marie A. Onyamboko, Caterina Fanello, Nicholas J. White, Nicholas P. J. Day, Richard M. Hoglund, Joel Tarning   +6 more
wiley   +1 more source

Development of a simple and specific direct competitive ELISA for the determination of artesunate using an anti-artesunate polyclonal antiserum [PDF]

, 2016
Background: Since artesunate (ART) became a vital component of artemisinin (ARM)-based combination therapies for the treatment for malaria,counterfeit ART drugs have spread in regions of Southeast Asia and Africa. The consumption of counterfeit ART drugs
Mitsui, Yoshinori, Yoshinori Mitsui, Yoshinori Mitsui   +2 more
core   +2 more sources

Protectiveness of Artesunate Given Prior Ischemic Cerebral Infarction Is Mediated by Increased Autophagy

Frontiers in Neurology, 2018
Background: Ischemic cerebral infarction is a severe clinical condition that can cause serious mortality. Artesunate, an anti-malarial drug that is widely used in cancer treatment, is known to facilitate accelerated cell apoptosis.
Ming Shao, Yue Shen, Hongjing Sun, Delong Meng, Wei Huo, Xu Qi   +5 more
doaj   +1 more source

Repurposing Drugs for Malaria through a Human Dose Prediction: A Case Study with Berzosertib

Clinical Pharmacology &Therapeutics, EarlyView.
Repurposing drugs whose clinical safety has been established offers a valuable approach to reduce the cost and time associated with the development of new drugs for malaria. Here, we investigate the potential to repurpose the anticancer kinase inhibitor berzosertib for the treatment of malaria, by assessing whether a predicted efficacious human dose ...
Devasha Redhi, Mwila Mulubwa, Mmakwena M. Mmonwa, Mathew Njoroge, Liezl Krugmann, Kelly Chibale   +5 more
wiley   +1 more source