Results 61 to 70 of about 26,165 (195)

Artesunate attenuates inflammatory injury and inhibits the NF-κB pathway in a mouse model of cerebral ischemia

Journal of International Medical Research, 2021
Objective Inflammation is an important factor in the pathological process of cerebral ischemia. Artesunate exhibits a broad range of anti-inflammatory properties in many diseases.
Ying Liu, Wei Dang, Shiyang Zhang, Lina Wang, Xiangjian Zhang   +4 more
doaj   +1 more source

Efficacy and safety of moxidectin, synriam, synriam-praziquantel versus praziquantel against schistosoma haematobium and S. mansoni infections: a randomized, exploratory phase 2 trial [PDF]

, 2016
Schistosomiasis affects millions of people, yet treatment options are limited. The antimalarial Synriam (piperaquine 150 mg/arterolane 750 mg) and the anthelminthic moxidectin revealed promising antischistosomal properties in preclinical or clinical ...
Barda, Beatrice, Coulibaly, Jean T., Hattendorf, Jan, Huwyler, Jörg, Keiser, Jennifer, Puchkov, Maxim   +5 more
core   +3 more sources

Artesunate Induces G0/G1 Phase Arrest in Tumor Cells and Associates With Cyclin‐Dependent Kinase 4 (CDK4)

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Background Non‐small cell lung cancer (NSCLC) is the leading cause of cancer‐related death worldwide. Cyclin‐dependent kinase 4 (CDK4) is a well‐validated oncogenic driver in NSCLC, yet current CDK4 inhibitors—predominantly based on the aminopyrimidine scaffold—are limited by structural homogeneity and the rapid emergence of acquired ...
Xinyu Chi, Qicong Chen, Gang Wang, Honglin Luo, Shenhong Qu, Xiaosu Zou   +5 more
wiley   +1 more source

Comparative study of efficacy of artesunate plus cotrimoxazole and artesunate plus chloroquine in the treatment of malaria in Nigerian children: a preliminary report [PDF]

Journal of Vector Borne Diseases, 2010
Background & objectives: The study was undertaken to evaluate the efficacy of cotrimoxazole plusartesunate and to compare the efficacy of this combination with that of artesunate plus chloroquinein the treatment of acute uncomplicated falciparum malaria ...
F.A. Fehintola, S.T. Balogun
doaj  

Hematological and biochemical effects of sub-chronic artesunate exposure in rats

Toxicology Reports, 2015
Artesunate is a potent and rapidly acting blood schizontocide used to treat chloroquine resistant malaria. Artesunate has been reported to cause embryo, reduced reproductive capacity, hepatotoxicity, neurotoxicity and hematological abnormalities ...
Papiya Bigoniya, Taranginee Sahu, Vikalp Tiwari   +2 more
doaj   +1 more source

Declining Burden of Plasmodium vivax in a Population in Northwestern Thailand from 1995 to 2016 before Comprehensive Primaquine Prescription for Radical Cure. [PDF]

, 2020
All Plasmodium cases have declined over the last decade in northwestern Thailand along the Myanmar border. During this time, Plasmodium vivax has replaced Plasmodium falciparum as the dominant species. The decline in P.
Carrara, Verena I, Charunwatthana, Prakaykaew, Chu, Cindy S, McGready, Rose, Nosten, François, Parker, Daniel M, Proux, Stéphane   +6 more
core  

Delayed haemolysis after treatment with intravenous artesunate in patients with severe malaria in India

Malaria Journal, 2020
Background Parenteral artesunate is the treatment of choice for severe malaria. It is safe, efficacious and well tolerated anti-malarial. However, delayed haemolysis has been reported in travellers, non-immune individuals and in African children. Methods
Deepali Savargaonkar, Manoj Kumar Das, Amar Verma, Jeevan K. Mitra, C. P. Yadav, Bina Srivastava, Anupkumar R. Anvikar, Neena Valecha   +7 more
doaj   +1 more source

Artesunate Alleviates Paclitaxel-Induced Neuropathic Pain in Mice by Decreasing Metabotropic Glutamate Receptor 5 Activity and Neuroinflammation in Primary Sensory Neurons

Frontiers in Molecular Neuroscience, 2022
Experimental studies on the pathogenetic process of paclitaxel-induced neuropathic pain (PINP) have been initially carried out, but PINP still has no effective therapy. Recently reported studies have highlighted the involvement of glutamate receptors and
Yize Li, Jiamin Kang, Ying Xu, Nan Li, Yang Jiao, Chenxu Wang, Chunyan Wang, Guolin Wang, Yonghao Yu, Jingjing Yuan, Linlin Zhang   +10 more
doaj   +1 more source

Primacy of effective communication and its influence on adherence to artemether-lumefantrine treatment for children under five years of age: a qualitative study. [PDF]

, 2012
BACKGROUND\ud \ud Prompt access to artemesinin-combination therapy (ACT) is not adequate unless the drug is taken according to treatment guidelines. Adherence to the treatment schedule is important to preserve efficacy of the drug.
A Chinbuah, A Rowe, C Carpenter, C Falade, C Hoepfl, C Wongsrichanalai, D Ofori-Adjei, D Simba, D Simba, D Simba, D Zurovac, Daudi O Simba, Deodatus Kakoko, E Ashley, E Rutebemberwa, J Cresswell, J Nsungwa-Sabiiti, J Todd, L Conteh, M Denscombe, M DiMatteo, M DiMatteo, M George, M Gomes, M Thiede, MQ Patton, N Beer, N White, N White, P Choo, P Piola, P Piola, P Travis, R Bogdan, R Ruslami, S Kvåle, S McCombie, S Sirima, S Yeung   +38 more
core   +5 more sources

Complete Dialysis‐Free Recovery From Severe Malaria–Associated Acute Kidney Injury and Multiorgan Failure: A Case Report and Brief Literature Review

Clinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT Severe malaria remains a major cause of acute kidney injury and multiorgan failure in endemic regions, often requiring renal replacement therapy. However, access to dialysis is limited in many resource‐constrained settings, making outcomes highly dependent on early diagnosis and effective antimalarial treatment. We report a 32‐year‐old man who
Tamirat Godebo Woyimo, Amare Hailu Ashine, Mohammed Kedir Shukri, Yonas Damtew Bejiga, Ragasa Getachew, Yosef Bekele Bonsa, Rediet Girmaye, Tsion Haile Woldemariam, Adugna Lamessa   +8 more
wiley   +1 more source