Results 61 to 70 of about 18,290 (191)

A randomized open-label trial of artesunate- sulfadoxine-pyrimethamine with or without primaquine for elimination of sub-microscopic P. falciparum parasitaemia and gametocyte carriage in eastern Sudan. [PDF]

, 2007
BACKGROUND: In areas of seasonal malaria transmission, treatment of asymptomatic carriers of malaria parasites, whose parasitaemia persists at low densities throughout the dry season, could be a useful strategy for malaria control.
El-Sayed, Badria, Ageep, Tellal, Salah-Eldin El-Zaki, Ahmed Babiker, Fathi Mansour, Nahla Gadalla, Tellal Ageep, Paul Milligan, El-Sayed Badria, Babiker Hamza, Baraka Omer, Babiker, Hamza, Milligan Paul, Milligan, Paul, El-Zaki Salah-Eldin, Omer Baraka, Gadalla Nahla, Gadalla, Nahla, Baraka, Omer, Babiker Ahmed, Ageep Tellal, Badria El-Sayed, Babiker, Ahmed, Mansour, Fathi, Mansour Fathi, Hamza Babiker, El-Zaki, Salah-Eldin   +26 more
core   +1 more source

First use of intravenous artesunate in Liberia and effect on patient mortality relative to artemeter and quinine: a cross-sectional study

The Lancet Global Health, 2014
Background: Intravenous artesunate reduces mortality by 35% relative to intravenous quinine. In 2010, WHO changed guidelines favouring intravenous artesunate, yet wide-scale adoption lags.
Dr. Wilson Wang, MD, Augustine Koryon, BS, Bernice Dahn, MD   +2 more
doaj   +1 more source

Oxaziridines: Versatile Reagents in Modern Organic Synthesis

The Chemical Record, EarlyView.
Being capable of transferring an O atom and N‐group/atom, oxaziridines are considered multitasking agents. These are employed for diverse organic transformations, such as epoxidation of olefins, α‐ and γ‐hydroxylation/amination of carbonyl compounds, oxidation of sulfides, [3+2]cycloaddition with unsaturated systems.
Ajeet Chandra, Subba Rao Cheekatla, Keshaba Nanda Parida   +2 more
wiley   +1 more source

Artemisinin combination therapies for treatment of uncomplicated malaria in Uganda. [PDF]

, 2006
OBJECTIVES: To compare the efficacy and safety of artemisinin combination therapies for the treatment of uncomplicated falciparum malaria in Uganda. DESIGN: Randomized single-blind controlled trial.
Staedke Sarah G, Rosenthal, Philip J, Yeka, Adoke, Banek, Kristin, Yeka Adoke, Dorsey, Grant, Staedke, Sarah G, Bakyaita Nathan, Dorsey Grant, Banek Kristin, Bukirwa, Hasifa, Talisuna Ambrose, Rosenthal Philip J, Talisuna, Ambrose, Rwakimari, John Bosco, Kamya Moses R, Kamya, Moses R, Bukirwa Hasifa, Wabwire-Mangen Fred, Bakyaita, Nathan, Wabwire-Mangen, Fred, Rwakimari John Bosco   +21 more
core   +1 more source

Artesunate Alleviates Paclitaxel-Induced Neuropathic Pain in Mice by Decreasing Metabotropic Glutamate Receptor 5 Activity and Neuroinflammation in Primary Sensory Neurons

Frontiers in Molecular Neuroscience, 2022
Experimental studies on the pathogenetic process of paclitaxel-induced neuropathic pain (PINP) have been initially carried out, but PINP still has no effective therapy. Recently reported studies have highlighted the involvement of glutamate receptors and
Yize Li, Jiamin Kang, Ying Xu, Nan Li, Yang Jiao, Chenxu Wang, Chunyan Wang, Guolin Wang, Yonghao Yu, Jingjing Yuan, Linlin Zhang   +10 more
doaj   +1 more source

Developmental Toxicity Study for the Antimalarial Drug Combination Cabamiquine‐Pyronaridine Using a Translational Approach

Birth Defects Research, Volume 118, Issue 10, October 2026.
ABSTRACT Background The safety of pharmacological treatments during pregnancy is a significant concern, as many medications lack comprehensive reproductive safety data. This creates gaps in therapeutic options for pregnant women, particularly malaria, which poses serious risks to maternal and fetal health.
Wookyung Kim, Geum‐Sil Cho, Andreas Gado, Tobias Hyun Ho Baeurle, Habib Karimi, Filippo Venezia, Claude Oeuvray, Thomas Spangenberg, Sebastian G. Wicha, Claudia Demarta‐Gatsi   +9 more
wiley   +1 more source

Simple field assays to check quality of current artemisinin-based antimalarial combination formulations. [PDF]

, 2009
INTRODUCTION: Malaria continues to be one of the major public health problems in Africa, Asia and Latin America. Artemisinin derivatives (ARTs; artesunate, artemether, and dihydroartemisinin) derived from the herb, Artemisia annua, are the most effective
Ioset, Jean-Robert, Kaur, Harparkash, Harparkash Kaur, Kaur Harparkash, Jean-Robert Ioset, Ioset Jean-Robert   +5 more
core   +2 more sources

Artesunate Decreases β-Catenin Expression, Cell Proliferation and Apoptosis Resistance in the MG-63 Human Osteosarcoma Cell Line

Cellular Physiology and Biochemistry, 2017
Background: This study aims to determine the effects of artesunate on proliferation, apoptosis and β-catenin expression in the human osteosarcoma cell line MG-63.
Peng Chen, Wan-Li Gu, Ming-Zhi Gong, Jun Wang, Dong-Qing Li   +4 more
doaj   +1 more source

Artesunate attenuates inflammatory injury and inhibits the NF-κB pathway in a mouse model of cerebral ischemia

Journal of International Medical Research, 2021
Objective Inflammation is an important factor in the pathological process of cerebral ischemia. Artesunate exhibits a broad range of anti-inflammatory properties in many diseases.
Ying Liu, Wei Dang, Shiyang Zhang, Lina Wang, Xiangjian Zhang   +4 more
doaj   +1 more source

High risk of severe anaemia after chlorproguanil-dapsone+artesunate antimalarial treatment in patients with G6PD (A-) deficiency. [PDF]

, 2008
BACKGROUND: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common inherited human enzyme defect. This deficiency provides some protection from clinical malaria, but it can also cause haemolysis after administration of drugs with oxidant ...
Modiano David, Fanello, C. I., Modiano, D., Karema, C., Lee, Sue, Bancone Germana, Uwimana, A, KAREMA C, Avellino Pamela, David Modiano, UWIMANA A, Uwimana, A., Fanello, CI, Germana Bancone, d'Alessandro Umberto, LEE SJ, Umberto d'Alessandro, Uwimana, Aline, Karema, C, Lee Sue J., Avellino, P, Modiano, D, Karema Corine, Pamela Avellino, Karema, Corine, D'Alessandro, U., D'ALESSANDRO U, Bancone, Germana, d'Alessandro, Umberto, Fanello Caterina I., Modiano, David, FANELLO CI, Fanello, Caterina I, Lee, S. J., Lee, Sue J, Sue J Lee, Corine Karema, Uwimana Aline, Aline Uwimana, D'Alessandro, U, Avellino, Pamela, Avellino, P., Caterina I Fanello, Bancone, G.   +43 more
core   +2 more sources