Results 81 to 90 of about 26,165 (195)

Varying efficacy of artesunate+amodiaquine and artesunate+sulphadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria in the Democratic Republic of Congo: a report of two in-vivo studies [PDF]

, 2009
BACKGROUND: Very few data on anti-malarial efficacy are available from the Democratic Republic of Congo (DRC). DRC changed its anti-malarial treatment policy to amodiaquine (AQ) and artesunate (AS) in 2005.
A Brockman, A Nahum, A Ndayiragije, AM Kabanywanyi, AO Talisuna, AP Alker, B Greenhouse, Chantal van Overmeir, CV Plowe, Célestin Nsibu Ndosimao, D Francis, Elizabeth Ashley, G Snounou, Ingrid van den Broek, Jean-Paul Guthmann, Jean-Paul Guthmann, JG Kublin, JG Kublin, JP Guthmann, Juliet Kyomuhendo, LC Ranford-Cartwright, M Ndounga, M Ndounga, Maryline Bonnet, Michel van Herp, MR Kamya, P Piola, Pedro Pablo Palma Urrutia, R Pearce, RN Price, S Cohuet, TB Swarthout, World Health Organization   +32 more
core   +2 more sources

Artemisinin‐Based Combination Therapies in East Africa: A Systematic Review of Quality, Clinical Efficacy, and Regulatory Progress Towards Sustainable Malaria Control

Tropical Medicine &International Health, Volume 31, Issue 3, Page 254-273, March 2026.
ABSTRACT Background Malaria is a major public health issue in East Africa, leading to widespread illness and fatalities, especially among vulnerable populations such as children under 5 years of age and pregnant women. Artemisinin‐based combination therapies (ACTs) are the primary treatment modality; however, their efficacy is undermined by the ...
Yesuneh Tefera Mekasha, Addisu Afrassa Tegegne, Tapfumanei Mashe, Million Girma, Gemmechu Hasen, Sileshi Belew   +5 more
wiley   +1 more source

Capacity strengthening in malaria research: the Gates Malaria Partnership.

, 2006
The Gates Malaria Partnership (GMP) includes five African and four European partner institutions. Its research programme has five priority areas involving an extensive range of field-based studies.
Bhasin, Amit, Bowler, Cathy H, Greenwood, Brian M, Naylor, Heather, Targett, Geoffrey A   +4 more
core   +1 more source

Rocaglates as dual-targeting agents for experimental cerebral malaria [PDF]

, 2018
Cerebral malaria (CM) is a severe and rapidly progressing complication of infection by Plasmodium parasites that is associated with high rates of mortality and morbidity.
Ayi, Kodjo, Brown, Lauren E., Cencic, Regina, Crandall, Ian, Gros, Philippe, Kain, Kevin C., Kennedy, James M., Langlais, David, Moradin, Neda, Pelletier, Jerry, Porco, John A., Schmeing, Martin, Tarry, Michael J.   +12 more
core   +1 more source

Antimalarial Polyethylene Glycol–Lumefantrine Conjugates: Synthesis and Effect of Linker Chemistry on Drug Release

Advanced Therapeutics, Volume 9, Issue 2, February 2026.
Research into advanced therapeutics for malaria are rare. We investigate how linker chemistry governs the release kinetics of the antimalarial lumefantrine from polyethylene glycol conjugates. A clear correlation between diacid linker length and drug release rate is established, enabling rational design of conjugates with controlled release.
Thenesia R. Govender, William M. R. Matshe, Nokuthula Dube, Zamani E. D. Cele, Aurelia A. Williams, Lynne A. Pilcher, Mohammed O. Balogun   +6 more
wiley   +1 more source

Surface‐Coated Inorganic Nanomaterials for Drug Delivery: Chemical Design, Biomedical Applications, and Mechanistic Insights

Advanced NanoBiomed Research, Volume 6, Issue 2, February 2026.
This review explores how surface‐coated inorganic nanomaterials are chemically engineered for advanced drug delivery. It highlights design principles, coating strategies, and biomedical applications, emphasizing how surface chemistry governs biocompatibility, targeting, and controlled release.
Hossein Daneshgar, Sepideh Ahmadi, Nikzad Abbariki, Navid Rabiee, Sidi A. Bencherif   +4 more
wiley   +1 more source

Artesunate [PDF]

Reactions Weekly, 2020
  +4 more sources

Anti-malarial drug artesunate restores metabolic changes in experimental allergic asthma [PDF]

, 2016
The anti-malarial drug artesunate possesses anti-inflammatory and anti-oxidative actions in experimental asthma, comparable to corticosteroid. We hypothesized that artesunate may modulate disease-relevant metabolic alterations in allergic asthma.
Cheng, Chang, Ho, Wanxing Eugene, Huang, Shao-Min, Ong, Choon Nam, Peh, Hong Yong, Tannenbaum, Steven R, Wong, W. S. Fred, Xu, Fengguo, Xu, Yong-Jiang   +8 more
core   +1 more source

A stratified random survey of the proportion of poor quality oral artesunate sold at medicine outlets in the Lao PDR – implications for therapeutic failure and drug resistance

Malaria Journal, 2009
Background Counterfeit oral artesunate has been a major public health problem in mainland SE Asia, impeding malaria control. A countrywide stratified random survey was performed to determine the availability and quality of oral artesunate in pharmacies ...
Vongsack Latsamy, Khounsaknalath Lamphet, Hostetler Dana, Mildenhall Dallas C, Nyadong Leonard, Hampton Christina Y, Insixiengmay Vongsavanh, Phommavong Khamlieng, Manolin Ot, Fernández Facundo M, Green Michael D, Sengaloundeth Sivong, Phompida Samlane, Vanisaveth Viengxay, Syhakhang Lamphone, Newton Paul N   +15 more
doaj   +1 more source

Malaria vaccine - is it still required? Are vaccine alternatives enough to achieve malaria control? [PDF]

, 2014
Despite ongoing continuous research towards developing a malaria vaccine, we have still not achieved this target and the malaria parasite continues to kill thousands, especially children in developing countries.
Fsadni, Claudia
core   +2 more sources