Results 71 to 80 of about 26,165 (195)

The Effect of Artesunate on Bleomycin‑Induced Pulmonary Fibrosis

Acta Clinica Croatica
Despite new drug alternatives, no curative treatment for idiopathic pulmonary fibrosis (IPF) currently exists. This study aimed to evaluate the effects of artesunate on fibrosis, pulmonary hypertension, and inflammation-related changes in IPF.
Aysun Şengul, Oğuzhan Okutan, Bülent Altınsoy, Ceyda Anar, Onur Yazıcı, Fazilet Dede, Sibel Köktürk, Cüneyt Özer, Osman Fuat Sönmez, Gökhan Metin   +9 more
doaj   +1 more source

Shifting from quinine to artesunate as first-line treatment of severe malaria in children and adults: Saving more lives

Journal of Infection and Public Health, 2014
Summary: Severe malaria kills more than a half million people each year. Based on high-quality evidence of the efficacy superiority of artesunate over quinine in adults and children with severe malaria, the World Health Organization guidelines have been ...
Jean Jacques N. Noubiap
doaj   +1 more source

Inventory Management Performance for Lifesaving Maternal and Child Health Medicines in Amhara Regional State, Ethiopia: A Facility‐Based Cross‐Sectional Mixed Method Study

Health Science Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background and Aims Maternal mortality is a major public health issue in Ethiopia, with 412 deaths per 100,000 live births. Pregnancy‐related causes make up 25% of female deaths, highlighting the crisis's seriousness. Improving inventory management could enhance health system performance.
Ayalew Sirbemo Degebo, Gizachew Tilahun
wiley   +1 more source

Prospective evaluation of BDProbeTec strand displacement amplification (SDA) system for diagnosis of tuberculosis in non-respiratory and respiratory samples. [PDF]

, 2004
Nucleic acid amplification techniques (NAATs) have been demonstrated to make significant improvements in the diagnosis of tuberculosis (TB), particularly in the time to diagnosis and the diagnosis of smear-negative TB. The BD ProbeTec strand displacement
Billington, OJ, Gillespie, SH, Gosling, RD, Ling, CL, Lipman, MC, McHugh, TD, Patel, S, Pope, CF   +7 more
core   +2 more sources

Disarming the Hsp70–Bim Alliance: Small‐Molecule and Peptidic Disruptors of a Chaperone‐Apoptotic Switch in Cancer

ChemistryOpen, Volume 15, Issue 4, April 2026.
Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel, Mohammed Al‐zharani, Lina M. Alneghery, Noha A. Ahmed, Faris F. Aba Alkhayl, Al Mokhtar Lamsabhi   +5 more
wiley   +1 more source

Targeting Ferroptosis With Natural Products for the Treatment of Skeletal System Disease: An Updated Review

Journal of Cellular and Molecular Medicine, Volume 30, Issue 7, April 2026.
ABSTRACT Skeletal system diseases, encompassing chronic disorders of the skeletal system which commonly include osteoarthritis, rheumatoid arthritis, osteoporosis and osteosarcoma. Their incidence rates have been increasing in recent years, resulting in significant social and economic burdens.
Qian Yi, Jinye Li, Guotian Luo, Jiachen Li, Dahang Yang, Wei Sun, Weichao Sun, Wei You, Lei Yang   +8 more
wiley   +1 more source

Simultaneous Spectrophotometric Estimation of Artesunate and Mefloquine

Journal of Chemistry, 2013
A simple, rapid, precise, and accurate UV-visible spectrophotometric method has been developed for the simultaneous determination of Artesunate in combination with Mefloquine. For developing the method, methanol was used as a solvent.
T. M. Kalyankar, R. B. Kakade, M. S. Attar, A. R. Kamble   +3 more
doaj   +1 more source

Attenuated Bacteria‐Based Tumor Therapy: Clinical Application Risks, Marketing Approval Restrictions, and Coping Strategies

Advanced Science, Volume 13, Issue 16, 18 March 2026.
This review comprehensively overviews attenuated bacteria‐based tumor therapy, highlighting key methodologies and recent progress. It examines strategies for enhancing safety, stabilizing efficacy, optimizing manufacturing, and navigating regulatory pathways.
Yucheng Liu, Junhong Yao, Jiaxin Deng, Minjie Zhou, Kaiyue Shen, Shishuo Sun, Xiaoge Gao, Qing Zhang, Haiheng Xu   +8 more
wiley   +1 more source

Trends and Patterns of Adverse Drug Reaction Reporting in Sierra Leone: A Retrospective Analysis of VigiFlow Data (2008–2022)

Pharmacoepidemiology and Drug Safety, Volume 35, Issue 3, March 2026.
ABSTRACT Purpose Adverse drug reactions (ADRs) present significant obstacles for healthcare systems, impacting both patient safety and the effectiveness of treatments. Despite this, there is a scarcity of research on ADR reports in Sierra Leone, especially over long periods.
Isatu Jalloh, Onome Thomas Abiri, Peter Bai James, Rajesh Vagiri, Neelaveni Padayachee   +4 more
wiley   +1 more source

Stimulation of Suicidal Erythrocyte Death by Artesunate

Cellular Physiology and Biochemistry, 2014
Background: The artemisinin derivative artesunate is effective in the treatment of severe malaria and is considered for the treatment of malignancy. Artesunate triggers tumor cell apoptosis, an effect at least in part mediated by mitochondria.
Kousi Alzoubi, Salvatrice Calabrò, Rosi Bissinger, Majed Abed, Caterina Faggio, Florian Lang   +5 more
doaj   +1 more source