Results 71 to 80 of about 18,290 (191)

Comparative study of efficacy of artesunate plus cotrimoxazole and artesunate plus chloroquine in the treatment of malaria in Nigerian children: a preliminary report [PDF]

Journal of Vector Borne Diseases, 2010
Background & objectives: The study was undertaken to evaluate the efficacy of cotrimoxazole plusartesunate and to compare the efficacy of this combination with that of artesunate plus chloroquinein the treatment of acute uncomplicated falciparum malaria ...
F.A. Fehintola, S.T. Balogun
doaj  

Hematological and biochemical effects of sub-chronic artesunate exposure in rats

Toxicology Reports, 2015
Artesunate is a potent and rapidly acting blood schizontocide used to treat chloroquine resistant malaria. Artesunate has been reported to cause embryo, reduced reproductive capacity, hepatotoxicity, neurotoxicity and hematological abnormalities ...
Papiya Bigoniya, Taranginee Sahu, Vikalp Tiwari   +2 more
doaj   +1 more source

Delayed haemolysis after treatment with intravenous artesunate in patients with severe malaria in India

Malaria Journal, 2020
Background Parenteral artesunate is the treatment of choice for severe malaria. It is safe, efficacious and well tolerated anti-malarial. However, delayed haemolysis has been reported in travellers, non-immune individuals and in African children. Methods
Deepali Savargaonkar, Manoj Kumar Das, Amar Verma, Jeevan K. Mitra, C. P. Yadav, Bina Srivastava, Anupkumar R. Anvikar, Neena Valecha   +7 more
doaj   +1 more source

Osteomyelitis: Epidemiology, Classification, Pathophysiology, Clinical Features, Diagnosis, and Management

MedComm, Volume 7, Issue 10, October 2026.
The immunosuppressive in OM Staphylococcus aureus employs multiple physical barriers to evade host immunity during skeletal infection, including biofilm formation on implant surfaces and necrotic bone tissues, invasion into the osteocyte lacuno‐canalicular network (OLCN), intracellular persistence within osteoblasts, osteoclasts, and osteocytes, and ...
Qingqiang Lei, Liangbin Lin, Peidong Pu, Jie Chen, Xianchao Su, Shubao Liu, Yanli Tong, Hui Yu   +7 more
wiley   +1 more source

Randomized trial of artesunate+amodiaquine, sulfadoxine-pyrimethamine+amodiaquine, chlorproguanal-dapsone and SP for malaria in pregnancy in Tanzania. [PDF]

, 2009
BACKGROUND: Malaria in pregnancy is serious, and drug resistance in Africa is spreading. Drugs have greater risks in pregnancy and determining the safety and efficacy of drugs in pregnancy is therefore a priority.
Greenwood, Brian M, Kandi Muze, Briceño, Marnie, Briceño Marnie, Christopher J. M. Whitty, Whitty Christopher J. M., Mutabingwa, Theonest K, I Muze, Drakeley, Chris, Ord Rosalynn, Chris Drakeley, Whitty, Christopher JM, Theonest K Mutabingwa, Ord, Rosalynn, Mutabingwa Theonest K., Drakeley Chris, Christopher J M Whitty, Theonest K. Mutabingwa, Greenwood Brian M., Brian M Greenwood, Rosalynn Ord, Brian M. Greenwood, Muze Kandi, Muze, Kandi, Marnie Briceño   +24 more
core   +1 more source

Versatile Detection of Cellular Protein via Fluorescence Anisotropy

Advanced Science, Volume 13, Issue 51, 14 September 2026.
Cell Lysate Fluorescence Anisotropy (CFAST) utilizes long lifetime dye‐labeled nanobodies for rapid protein quantification in minimally purified, complex cell lysate. When coupled with cellular thermal shift, CFAST allows high‐throughput detection of endogenous protein‐small molecule engagement, facilitating the discovery of novel binders for ...
Qing Tang, Yuan‐Ping Wei, Ricky Ruiqi Ma, Na Wei, Tammy Zihan Zhou, Hilary Kung‐Yu Ho, Zafar Iqbal Bhat, Iqra Ishrat, Xiaoyu Li, Judy Wai Ping Yam, Yung Hou Wong, Qiankun Wang, Justin L. Tan   +12 more
wiley   +1 more source

The Effect of Artesunate on Bleomycin‑Induced Pulmonary Fibrosis

Acta Clinica Croatica
Despite new drug alternatives, no curative treatment for idiopathic pulmonary fibrosis (IPF) currently exists. This study aimed to evaluate the effects of artesunate on fibrosis, pulmonary hypertension, and inflammation-related changes in IPF.
Aysun Şengul, Oğuzhan Okutan, Bülent Altınsoy, Ceyda Anar, Onur Yazıcı, Fazilet Dede, Sibel Köktürk, Cüneyt Özer, Osman Fuat Sönmez, Gökhan Metin   +9 more
doaj   +1 more source

Shifting from quinine to artesunate as first-line treatment of severe malaria in children and adults: Saving more lives

Journal of Infection and Public Health, 2014
Summary: Severe malaria kills more than a half million people each year. Based on high-quality evidence of the efficacy superiority of artesunate over quinine in adults and children with severe malaria, the World Health Organization guidelines have been ...
Jean Jacques N. Noubiap
doaj   +1 more source

Malaria‐Associated Secondary Hematophagocytic Lymphohistocytosis—A Case Report and Comprehensive Literature Review (sHLH)

Clinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT Malaria‐associated secondary HLH, though rare, is often overlooked. Clinicians should maintain a high‐index of suspicion in travelers returning from malaria‐endemic regions who develop severe to rapidly worsening inflammatory illness, as early recognition is critical for survival.
Indresh Yadav, Sulav Kumar Jha, Sweta Singh, Dipesh Kumar Mandal, Saurav Jha   +4 more
wiley   +1 more source

Mechanobiological feedback loops and quantitative decision thresholds in organ fibrosis: Translational principles for antifibrotic therapy

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
Multiorgan fibrosis arises when chronic injury activates fibroblasts and remodels extracellular matrix, whose increasing stiffness sustains disease through mechanotransduction pathways. Bidirectional cellular‐matrix feedback operates across lung, heart, liver, and kidney.
Amedeo Lonardo, Ralf Weiskirchen
wiley   +1 more source