Results 31 to 40 of about 17,074 (196)

Pre-referral intranasal artesunate powder for cerebral malaria: a proof-of-concept study

Malaria Journal, 2022
Background Malaria still kills young children in rural endemic areas because early treatment is not available. Thus, the World Health Organization recommends the administration of artesunate suppositories as pre-referral treatment before transportation ...
Yobouet Ines Kouakou, Aurelien Millet, Elodie Fromentin, Nathalie Hauchard, Gonçalo Farias, Maxime Fieux, Aurelie Coudert, Roukayatou Omorou, Ibrahim Bin Sa’id, Adeline Lavoignat, Guillaume Bonnot, Anne-Lise Bienvenu, Stephane Picot   +12 more
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Artesunate reduces but does not prevent posttreatment transmission of Plasmodium falciparum to Anopheles gambiae. [PDF]

, 2001
Combination therapy that includes artemisinin derivatives cures most falciparum malaria infections. Lowering transmission by reducing gametocyte infectivity would be an additional benefit.
Targett, G, Jawara, M, Doherty, T, Milligan, P, von Seidlein, L, Sutherland, C, Drakeley, C, Coleman, R, Pinder, M, Walraven, G, Deen, J   +10 more
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Artemisinin resistance in Plasmodium falciparum malaria. [PDF]

, 2009
BACKGROUND: Artemisinin-based combination therapies are the recommended first-line treatments of falciparum malaria in all countries with endemic disease.
Yi, Poravuth, Singhasivanon, Pratap, Day, Nicholas PJ, Ariey, Frederic, Lindegardh, Niklas, Lim, Pharath, Dondorp, Arjen M, Ringwald, Pascal, Socheat, Duong, Hanpithakpong, Warunee, Silamut, Kamolrat, Lwin, Khin Maung, Imwong, Mallika, Phyo, Aung Phae, Das, Debashish, Lee, Sue J, Herdman, Trent, White, Nicholas J, Chotivanich, Kesinee, Yeung, Shunmay, Tarning, Joel, Nosten, François, An, Sen Sam   +22 more
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Artesunate-induced testicular injury: Oil from selected spices blend modulates redox homeostasis and exacerbates steroidogenesis in rat models

Clinical Nutrition Experimental, 2016
The therapeutic potential of oil from blends of selected culinary spices against artesunate-induced testicular injury in albino rats was investigated. Two groups of rats each were pretreated with the oil at 1.5 and 3.00 mL respectively for seven days and
John A. Ajiboye, Ochuko L. Erukainure, Emeka E. Okoro, Godfrey Asieba   +3 more
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Pre-clinical study of iron oxide nanoparticles fortified artesunate for efficient targeting of malarial parasiteResearch in context

EBioMedicine, 2019
Background: Artesunate the most potent antimalarial is widely used for the treatment of multidrug-resistant malaria. The antimalarial cytotoxicity of artesunate has been mainly attributed to its selective, irreversible and iron- radical-mediated damage ...
Deepika Kannan, Nisha Yadav, Shakeel Ahmad, Pragya Namdev, Souvik Bhattacharjee, Bimlesh Lochab, Shailja Singh   +6 more
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Parasitaemia and gametocytaemia after treatment with chloroquine, pyrimethamine/sulfadoxine, and pyrimethamine/sulfadoxine combined with artesunate in young Gambians with uncomplicated malaria. [PDF]

, 2001
As part of a study to assess the infectivity of gametocytes after treatment with four antimalarial regimens, the efficacy of each treatment was also determined.
Targett, G, Gijs Walraven, Jawara, M, Doherty, T, Lorenz von Seidlein, Tom Doherty, von Seidlein, L, Coleman, R, Musa Jawara, Geoffrey Targett, Rosalind Coleman, Walraven, G   +11 more
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Primaquine clears submicroscopic Plasmodium falciparum gametocytes that persist after treatment with sulphadoxine-pyrimethamine and artesunate. [PDF]

, 2007
BACKGROUND: P. falciparum gametocytes may persist after treatment with sulphadoxine-pyrimethamine (SP) plus artesunate (AS) and contribute considerably to malaria transmission.
Alifrangis, M., Mosha, F., Anders Enevold, Bousema, Teun, Arnold Ndaro, Shekalaghe Seif, Shekalaghe, Seif, van Meegeren Monique, Sauerwein Robert, Sauerwein, R.W., Seif Shekalaghe, Gosling Roly, Shekalaghe, S., Ndaro, A., Frank Mosha, Enevold Anders, Drakeley, Chris, Gosling, R., Chris Drakeley, Monique van Meegeren, Teun Bousema, Meegeren, M. van, Robert Sauerwein, van Meegeren, Monique, Enevold, A., Bousema, T., Sauerwein, R., Mosha, Frank, Alifrangis Michael, Drakeley Chris, Bousema Teun, Ndaro Arnold, Gosling, Roly, Drakeley, C., Enevold, Anders, Michael Alifrangis, Alifrangis, Michael, Sauerwein, Robert, Mosha Frank, Meegeren, M.E.R. van, Roly Gosling, Ndaro, Arnold   +41 more
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A randomised controlled trial to assess the efficacy of dihydroartemisinin-piperaquine for the treatment of uncomplicated falciparum malaria in Peru [PDF]

, 2007
Background. Multi-drug resistant falciparum malaria is an important health problem in the Peruvian Amazon region. We carried out a randomised open label clinical trial comparing mefloquine-artesunate, the current first line treatment in this region, with
Casapia, M, Bernasconi, Andrea, Torres, Kathy, Grande, Tanilu, Erhart, Annette, Llanos-Cuentas, A., Umberto D'Alessandro, D'Alessandro Umberto, Caterina Fanello, Torres, K., Christopher Delgado, Grande, T., Casapia Martin, Casapia, M., D'Alessandro, U., Delgado, C, Fanello, C., Grande, T, Llanos-Cuentas Alejandro, Gamboa Dioni, Delgado Christopher, Erhart, A., Bernasconi, A., Tanilu Grande, Torres Kathy, Martin Casapia, Delgado, Christopher, Erhart, A, Fanello Caterina, Torres, K, Llanos-Cuentas, A, Andrea Bernasconi, Llanos-Cuentas, Alejandro, Delgado, C., Gamboa, Dioni, Bernasconi Andrea, Gamboa, D, Fanello, C, Fanello, Caterina, Gamboa, D., Bernasconi, A, Kathy Torres, Casapia, Martin, Alejandro Llanos-Cuentas, D'Alessandro, Umberto, Dioni Gamboa, Annette Erhart, D'Alessandro, U, Grande Tanilu, Erhart Annette   +49 more
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Safety and efficacy of methylene blue combined with artesunate or amodiaquine for uncomplicated falciparum malaria [PDF]

, 2008
Besides existing artemisinin-based combination therapies, alternative safe, effective and affordable drug combinations against falciparum malaria are needed. Methylene blue (MB) was the first synthetic antimalarial drug ever used, and recent studies have
Walter-Sack, Ingeborg, Coulibaly, Boubacar, Sié, Ali, Schirmer, R. Heiner, Zoungrana, Augustin, Meissner, Peter E., Müller, Olaf, Kouyaté, Bocar, Klose, Christina, Mockenhaupt, Frank P., Mansmann, Ulrich   +10 more
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The application of nano artesunate mixture in biomedicine

Tạp chí Khoa học Đại học Mở Thành phố Hồ Chí Minh - Kỹ thuật và Công nghệ, 2019
In this paper, nano β-cyclodextrin-alginate-artesunate nanoparticles ranging from 20nm to 80nm were synthesized, the fairly uniform diameters of particles were applied to enhance drug delivery.
Phạm Thị Hồng Tân
doaj   +1 more source