Results 31 to 40 of about 18,290 (191)

Oral activated charcoal prevents experimental cerebral malaria in mice and in a randomized controlled clinical trial in man did not interfere with the pharmacokinetics of parenteral artesunate. [PDF]

, 2010
BACKGROUND: Safe, cheap and effective adjunct therapies preventing the development of, or reducing the mortality from, severe malaria could have considerable and rapid public health impact.
Conway, David J, Owens, Benjamin MJ, Harparkash Kaur, Brian M J Foxwell, Sumariwalla, Percy F., Percy F Sumariwalla, Kevin J Tracey, Sant Muangnoicharoen, Paul M Kaye, Conway, David J., Ulloa, Luis, Kaye, Paul M., de Souza, J Brian, Muangnoicharoen, Sant, Luis Ulloa, David J Conway, Warhurst, David C., Tracey, Kevin J, Ward, Steve, Sumariwalla, Percy F, Michael Walther, Stephen A Ward, Ward, Stephen A, Uduak Okomo, Alexander, Neal D, Momodou Jasseh, Aziz, Naveed, Walther, Michael, Naveed Aziz, Tracey, Kevin J., Jasseh, Momodou, de Souza, Brian B., David C Warhurst, Kaur, Harparkash, Foxwell, Brian MJ, Warhurst, David C, Neal D Alexander, Owens, Benjamin M.J., Benjamin M J Owens, Okomo, Uduak, Foxwell, Brian M.J., J Brian de Souza, Alexander, Neal D., Kaye, Paul M   +43 more
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Pre-referral intranasal artesunate powder for cerebral malaria: a proof-of-concept study

Malaria Journal, 2022
Background Malaria still kills young children in rural endemic areas because early treatment is not available. Thus, the World Health Organization recommends the administration of artesunate suppositories as pre-referral treatment before transportation ...
Yobouet Ines Kouakou, Aurelien Millet, Elodie Fromentin, Nathalie Hauchard, Gonçalo Farias, Maxime Fieux, Aurelie Coudert, Roukayatou Omorou, Ibrahim Bin Sa’id, Adeline Lavoignat, Guillaume Bonnot, Anne-Lise Bienvenu, Stephane Picot   +12 more
doaj   +1 more source

Open-label comparative clinical study of chlorproguanil−dapsone fixed dose combination (Lapdap™) alone or with three different doses of artesunate for uncomplicated plasmodium falciparum malaria [PDF]

, 2008
The objective of this study was to determine the appropriate dose of artesunate for use in a fixed dose combination therapy with chlorproguanil−dapsone (CPG−DDS) for the treatment of uncomplicated falciparum ...
Peter A Winstanley, Nyirenda, Maggie, Kanjala, Maxwell K., Molyneux, Malcolm, Sam Dunyo, Stephan Duparc, Paula L Kirby, Winstanley Peter A., Kirby, Paula L., Blencowe, Hannah, Daniel G Wootton, Woessner, Mary, Thomas Kanyok, Stephen Ward, Opara, Hyginus, Molyneux Malcolm, Winstanley, Peter A, Wootton Daniel G., Maggie Nyirenda, Ward, Stephen, Dunyo, Sam, Giancarlo A Biagini, Kanjala, Maxwell K, Nyirenda Maggie, Kanyok Thomas, Maxwell K Kanjala, Opara Hyginus, Duparc, Stephan, Kanyok, Thomas, Queen Dube-Mbeye, Duparc Stephan, Malcolm Molyneux, Neate, Colin, Biagini, Giancarlo A, Biagini Giancarlo A., Ward Stephen, Kirby Paula L., Wootton, Daniel G., Wootton, Daniel G, Kirby, Paula L, Hannah Blencowe, Mary Woessner, Kanjala Maxwell K., Molyneux, Malcolm E., Biagini, Giancarlo A., Woessner Mary, Dube-Mbeye Queen, Colin Neate, Hyginus Opara, Neate Colin, Blencowe Hannah, Dunyo Sam, Winstanley, Peter, Dube-Mbeye, Queen, Ward, Steve, Biagini, Giancarlo; id_orcid, Winstanley, Peter A.   +56 more
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KEAP1 Is Required for Artesunate Anticancer Activity in Non-Small-Cell Lung Cancer [PDF]

, 2021
Artesunate is the most common treatment for malaria throughout the world. Artesunate has anticancer activity likely through the induction of reactive oxygen species, the same mechanism of action utilized in Plasmodium falciparum infections. Components of
J. Robert McCorkle, Plattner, Rina, Erin Schuler, Sally R. Ellingson, McCorkle, J. Robert, Anthony McDowell, Hill, Kristen S., Jill M. Kolesar, Rina Plattner, Kolesar, Jill M., McDowell, Anthony, Jr., Ellingson, Sally R., Kristen S. Hill, Schuler, Erin   +13 more
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Artesunate-induced testicular injury: Oil from selected spices blend modulates redox homeostasis and exacerbates steroidogenesis in rat models

Clinical Nutrition Experimental, 2016
The therapeutic potential of oil from blends of selected culinary spices against artesunate-induced testicular injury in albino rats was investigated. Two groups of rats each were pretreated with the oil at 1.5 and 3.00 mL respectively for seven days and
John A. Ajiboye, Ochuko L. Erukainure, Emeka E. Okoro, Godfrey Asieba   +3 more
doaj   +1 more source

Parasitaemia and gametocytaemia after treatment with chloroquine, pyrimethamine/sulfadoxine, and pyrimethamine/sulfadoxine combined with artesunate in young Gambians with uncomplicated malaria. [PDF]

, 2001
As part of a study to assess the infectivity of gametocytes after treatment with four antimalarial regimens, the efficacy of each treatment was also determined.
Targett, G, Gijs Walraven, Jawara, M, Doherty, T, Lorenz von Seidlein, Tom Doherty, von Seidlein, L, Coleman, R, Musa Jawara, Geoffrey Targett, Rosalind Coleman, Walraven, G   +11 more
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Pre-clinical study of iron oxide nanoparticles fortified artesunate for efficient targeting of malarial parasiteResearch in context

EBioMedicine, 2019
Background: Artesunate the most potent antimalarial is widely used for the treatment of multidrug-resistant malaria. The antimalarial cytotoxicity of artesunate has been mainly attributed to its selective, irreversible and iron- radical-mediated damage ...
Deepika Kannan, Nisha Yadav, Shakeel Ahmad, Pragya Namdev, Souvik Bhattacharjee, Bimlesh Lochab, Shailja Singh   +6 more
doaj   +1 more source

Primaquine clears submicroscopic Plasmodium falciparum gametocytes that persist after treatment with sulphadoxine-pyrimethamine and artesunate. [PDF]

, 2007
BACKGROUND: P. falciparum gametocytes may persist after treatment with sulphadoxine-pyrimethamine (SP) plus artesunate (AS) and contribute considerably to malaria transmission.
Alifrangis, M., Mosha, F., Anders Enevold, Bousema, Teun, Arnold Ndaro, Shekalaghe Seif, Shekalaghe, Seif, van Meegeren Monique, Sauerwein Robert, Sauerwein, R.W., Seif Shekalaghe, Gosling Roly, Shekalaghe, S., Ndaro, A., Frank Mosha, Enevold Anders, Drakeley, Chris, Gosling, R., Chris Drakeley, Monique van Meegeren, Teun Bousema, Meegeren, M. van, Robert Sauerwein, van Meegeren, Monique, Enevold, A., Bousema, T., Sauerwein, R., Mosha, Frank, Alifrangis Michael, Drakeley Chris, Bousema Teun, Ndaro Arnold, Gosling, Roly, Drakeley, C., Enevold, Anders, Michael Alifrangis, Alifrangis, Michael, Sauerwein, Robert, Mosha Frank, Meegeren, M.E.R. van, Roly Gosling, Ndaro, Arnold   +41 more
core   +2 more sources

A randomised controlled trial to assess the efficacy of dihydroartemisinin-piperaquine for the treatment of uncomplicated falciparum malaria in Peru [PDF]

, 2007
Background. Multi-drug resistant falciparum malaria is an important health problem in the Peruvian Amazon region. We carried out a randomised open label clinical trial comparing mefloquine-artesunate, the current first line treatment in this region, with
Casapia, M, Bernasconi, Andrea, Torres, Kathy, Grande, Tanilu, Erhart, Annette, Llanos-Cuentas, A., Umberto D'Alessandro, D'Alessandro Umberto, Caterina Fanello, Torres, K., Christopher Delgado, Grande, T., Casapia Martin, Casapia, M., D'Alessandro, U., Delgado, C, Fanello, C., Grande, T, Llanos-Cuentas Alejandro, Gamboa Dioni, Delgado Christopher, Erhart, A., Bernasconi, A., Tanilu Grande, Torres Kathy, Martin Casapia, Delgado, Christopher, Erhart, A, Fanello Caterina, Torres, K, Llanos-Cuentas, A, Andrea Bernasconi, Llanos-Cuentas, Alejandro, Delgado, C., Gamboa, Dioni, Bernasconi Andrea, Gamboa, D, Fanello, C, Fanello, Caterina, Gamboa, D., Bernasconi, A, Kathy Torres, Casapia, Martin, Alejandro Llanos-Cuentas, D'Alessandro, Umberto, Dioni Gamboa, Annette Erhart, D'Alessandro, U, Grande Tanilu, Erhart Annette   +49 more
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Safety and efficacy of methylene blue combined with artesunate or amodiaquine for uncomplicated falciparum malaria [PDF]

, 2008
Besides existing artemisinin-based combination therapies, alternative safe, effective and affordable drug combinations against falciparum malaria are needed. Methylene blue (MB) was the first synthetic antimalarial drug ever used, and recent studies have
Walter-Sack, Ingeborg, Coulibaly, Boubacar, Sié, Ali, Schirmer, R. Heiner, Zoungrana, Augustin, Meissner, Peter E., Müller, Olaf, Kouyaté, Bocar, Klose, Christina, Mockenhaupt, Frank P., Mansmann, Ulrich   +10 more
core   +1 more source