Results 21 to 30 of about 18,290 (191)

Feasibility and acceptability of injectable artesunate for the treatment of severe malaria in the Democratic Republic of Congo [PDF]

, 2016
The Democratic Republic of the Congo (DRC) changed its national policy for the treatment of severe malaria in both children and adults in 2012 from intravenous quinine to injectable artesunate.
Lengeler, Christian, Henry M. T. Ntuku, Tshefu, Antoinette K., Christian Lengeler, Ntuku Et Al. Malar J, Christian Burri, Antoinette K. Tshefu, Kalemwa, Didier M., Henry M. T. Ntuku, Gianfrancesco Ferrari, Burri, Christian, Didier M. Kalemwa, Ferrari, Gianfrancesco, Ntuku, Henry M. T.   +13 more
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Nrf2 inhibition reverses the resistance of cisplatin-resistant head and neck cancer cells to artesunate-induced ferroptosis

Redox Biology, 2017
Artesunate, an anti-malarial drug, has been repurposed as an anticancer drug due to its induction of cell death via reactive oxygen species (ROS) production.
Jong-Lyel Roh, Eun Hye Kim, Hyejin Jang, Daiha Shin   +3 more
doaj   +1 more source

Artesunate Therapy Alleviates Fracture-Associated Chronic Pain After Orthopedic Surgery by Suppressing CCL21-Dependent TREM2/DAP12 Inflammatory Signaling in Mice

Frontiers in Pharmacology, 2022
Chronic pain after bone fracture and orthopedic surgery is often refractory to most analgesics currently in use, thus emphasizing the urgent need for improved therapeutic medications.
Linlin Zhang, Linlin Zhang, Nan Li, Nan Li, Haoyue Zhang, Haoyue Zhang, Yigang Wang, Yigang Wang, Tianyu Gao, Tianyu Gao, Yuying Zhao, Yuying Zhao, Guolin Wang, Guolin Wang, Yonghao Yu, Yonghao Yu, Chunyan Wang, Chunyan Wang, Yize Li, Yize Li   +19 more
doaj   +1 more source

Development of resistance towards artesunate in MDA-MB-231 human breast cancer cells. [PDF]

, 2011
Breast cancer is the most common cancer and the second leading cause of cancer death in industrialized countries. Systemic treatment of breast cancer is effective at the beginning of therapy.
Ulrich Pfeffer, Killian, Peter H., Fichtner Iduna, Efferth, Thomas, Iduna Fichtner, Pfeffer Ulrich, Pfeffer, U., Emanuel Kronski, Bachmeier Beatrice, Killian, P.H., Fichtner, I., Beatrice Bachmeier, Bachmeier, B., Thomas Efferth, Kronski, Emanuel, Efferth Thomas, Kronski, E., Pfeffer, Ulrich, Fichtner, Iduna, Bachmeier, Beatrice, Peter H. Killian, Peter H Killian, Efferth, T., Kronski Emanuel, Killian Peter H.   +24 more
core   +1 more source

An operational comparative study of quinine and artesunate for the treatment of severe malaria in hospitals and health centres in the Democratic Republic of Congo : the MATIAS study [PDF]

, 2015
The Democratic Republic of the Congo (DRC) has the highest number of severe malaria cases in the world. In early 2012, the National Malaria Control Programme (NMCP) changed the policy for treating severe malaria in children and adults from injectable ...
Lengeler, Christian, Musafiri, Papa N., Tshefu, Antoinette K., Ross, Amanda, Duparc, Stephan, Hugo, Pierre, Luwawu, Joseph N., Ngoie, Symphorien E., Ngwala, Philippe L., Mitembo, Didier K., Burri, Christian, Ferrari, Giovanfrancesco, Ntuku, Henry M.   +12 more
core   +1 more source

Radio-sensitizing potential of artesunate is mediated by targeting stemness and hypoxia markers in solid Ehrlich tumor implanted in mice [PDF]

Egyptian Journal of Cancer and Biomedical Research
Background: Despite the development of various treatment strategies, cancer remains the main cause of death worldwide. Aim: The purpose of this study was to investigate the antitumor effects and radio sensitizing effect of artesunate in combination with ...
Mohamed Morsi, Sanaa El-benhawy, Samar Elblehi, Osama Almesrati, Amal Arab   +4 more
doaj   +1 more source

Praziquantel, mefloquine-praziquantel, and mefloquine-artesunate-praziquantel against Schistosoma haematobium : a randomized, exploratory, open-label trial [PDF]

, 2014
Treatment and morbidity control of schistosomiasis relies on a single drug, praziquantel. Hence, there is a pressing need to develop additional therapeutics against schistosomiasis.
Silué, Kigbafori D., Monsan, N'Chou, Jennifer Keiser, Eliézer K. N'Goran (108853), Utzinger, Jürg, Nicaise A. N'Guessan (195087), Nicaise A N'Guessan, Adiossan, Lukas K., Lukas K Adiossan, Jürg Utzinger (39609), N'Chou Monsan, Kigbafori D. Silué (128980), Eliézer K N'Goran, Keiser, Jennifer, N'Chou Monsan (599780), N'Goran, Eliézer K., Jennifer Keiser (39606), N'Guessan, Nicaise A., Kigbafori D Silué, Jürg Utzinger, Lukas K. Adiossan (599779)   +20 more
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Effects of Artesunate on the Invasion of Lung Adenocarcinoma A549 Cells
and Expression of ICAM-1 and MMP-9

Chinese Journal of Lung Cancer, 2013
Background and objective Artesunate, an anti-malarial drug, elicits an inhibitory effect on pulmonary carcinoma. However, the mechanisms of artesunate activity on pulmonary carcinoma have not been completely elucidated.
Xianshan CHEN, Kunyuan HAN, Fengxia CHEN, Congming WU, Weiyi HUANG   +4 more
doaj   +1 more source

Artesunate shows potent anti-tumor activity in B-cell lymphoma

Journal of Hematology & Oncology, 2018
Background Although chemo-immunotherapy has led to an improved overall survival for most B-cell lymphoma types, relapsed and refractory disease remains a challenge. The malaria drug artesunate has previously been identified as a growth suppressor in some
Thea Kristin Våtsveen, Marit Renée Myhre, Chloé Beate Steen, Sébastien Wälchli, Ole Christian Lingjærde, Baoyan Bai, Pierre Dillard, Theodossis A. Theodossiou, Toril Holien, Anders Sundan, Else Marit Inderberg, Erlend B. Smeland, June Helen Myklebust, Morten P. Oksvold   +13 more
doaj   +1 more source

Chlorproguanil−Dapsone−Artesunate versus Artemether−Lumefantrine : a randomized, double-blind phase III trial in African children and adolescents with uncomplicated plasmodium falciparum malaria [PDF]

, 2009
Chlorproguanil−dapsone−artesunate (CDA) was developed as an affordable, simple, fixed-dose artemisinin-based combination therapy for use in Africa. This trial was a randomized parallel-group, double-blind, double-dummy study to compare CDA and artemether−
Peter A Winstanley, Pamba Allan, Guiguemdé, Robert, Stephan Duparc, Paula L Kirby, Esamai, Fabian, Ezedinachi, Emmanuel U, Ward, S.A., Umeh, Rich E., Borrmann Steffen, Winstanley Peter A., Kirby, Paula L., Kellam, Lynda, Premji, Z., Greenwood, Brian, Ward, Stephen A, Premji, Zul, Lynda Kellam, Ezedinachi Emmanuel U., Oguche, Stephen, Owusu-Agyei, S., Stephen Oguche, Greenwood Brian, Oguche Stephen, Owusu-Agyei Seth, Winstanley, Peter A, Oguche, S, Emmanuel U Ezedinachi, Pamba, Allan, Rich E Umeh, Greenwood, B., Umeh Rich E., Zul Premji, Kellam, L., Winstanley, P.A., Duparc, Stephan, Owusu-Agyei, Seth, Duparc Stephan, Guiguemdé Robert, Guiguemde, R., Ward, S. A., Umeh, Rich Enujioke, Allan Pamba, Ward, Steve, Fabian Esamai, Ezedinachi, Emmanuel U., Umeh, R.E., Stephen A Ward, Kellam Lynda, Premji Zul, Esamai Fabian, Duparc, S., Kirby Paula L., Sowunmi Akintunde, Kirby, Paula L, Brian Greenwood, Pamba, A., Kirby, P.L., Rénia, Laurent, Ward Stephen A., Borrmann, S., Seth Owusu-Agyei, Robert Guiguemdé, Akintunde Sowunmi, Sowunmi, Akintunde, Ezedinachi, E.U., Umeh, Rich E, Sowunmi, A., Oguche, S., Borrmann, Steffen, Esamai, F., Steffen Borrmann, Winstanley, Peter, Winstanley, Peter A.   +73 more
core   +1 more source