Results 21 to 30 of about 17,074 (196)

Radio-sensitizing potential of artesunate is mediated by targeting stemness and hypoxia markers in solid Ehrlich tumor implanted in mice [PDF]

Egyptian Journal of Cancer and Biomedical Research
Background: Despite the development of various treatment strategies, cancer remains the main cause of death worldwide. Aim: The purpose of this study was to investigate the antitumor effects and radio sensitizing effect of artesunate in combination with ...
Mohamed Morsi, Sanaa El-benhawy, Samar Elblehi, Osama Almesrati, Amal Arab   +4 more
doaj   +1 more source

An operational comparative study of quinine and artesunate for the treatment of severe malaria in hospitals and health centres in the Democratic Republic of Congo : the MATIAS study [PDF]

, 2015
The Democratic Republic of the Congo (DRC) has the highest number of severe malaria cases in the world. In early 2012, the National Malaria Control Programme (NMCP) changed the policy for treating severe malaria in children and adults from injectable ...
Lengeler, Christian, Musafiri, Papa N., Tshefu, Antoinette K., Ross, Amanda, Duparc, Stephan, Hugo, Pierre, Luwawu, Joseph N., Ngoie, Symphorien E., Ngwala, Philippe L., Mitembo, Didier K., Burri, Christian, Ferrari, Giovanfrancesco, Ntuku, Henry M.   +12 more
core   +1 more source

In-vivo efficacy of amodiaquine-artesunate in children with uncomplicated Plasmodium falciparum malaria in western Kenya. [PDF]

, 2009
OBJECTIVES: To assess the efficacy of amodiaquine-artesunate in an area with high chloroquine resistance in western Kenya. METHODS: Twenty-eight day in-vivo efficacy trial of amodiaquine-artesunate in 103 children aged 6-59 months in western Kenya with ...
Thwing, JI, Slutsker, L, Odero, CO, McMorrow, M, Hamel, MJ, Desai, M, Odhiambo, FO, Otieno, KO, Kariuki, S, Roper, C, Vulule, J, Newman, RD, Ord, R   +12 more
core   +1 more source

KEAP1 Is Required for Artesunate Anticancer Activity in Non-Small-Cell Lung Cancer [PDF]

, 2021
Artesunate is the most common treatment for malaria throughout the world. Artesunate has anticancer activity likely through the induction of reactive oxygen species, the same mechanism of action utilized in Plasmodium falciparum infections. Components of
J. Robert McCorkle, Plattner, Rina, Erin Schuler, Sally R. Ellingson, McCorkle, J. Robert, Anthony McDowell, Hill, Kristen S., Jill M. Kolesar, Rina Plattner, Kolesar, Jill M., McDowell, Anthony, Jr., Ellingson, Sally R., Kristen S. Hill, Schuler, Erin   +13 more
core   +2 more sources

Praziquantel, mefloquine-praziquantel, and mefloquine-artesunate-praziquantel against Schistosoma haematobium : a randomized, exploratory, open-label trial [PDF]

, 2014
Treatment and morbidity control of schistosomiasis relies on a single drug, praziquantel. Hence, there is a pressing need to develop additional therapeutics against schistosomiasis.
Silué, Kigbafori D., Monsan, N'Chou, Jennifer Keiser, Eliézer K. N'Goran (108853), Utzinger, Jürg, Nicaise A. N'Guessan (195087), Nicaise A N'Guessan, Adiossan, Lukas K., Lukas K Adiossan, Jürg Utzinger (39609), N'Chou Monsan, Kigbafori D. Silué (128980), Eliézer K N'Goran, Keiser, Jennifer, N'Chou Monsan (599780), N'Goran, Eliézer K., Jennifer Keiser (39606), N'Guessan, Nicaise A., Kigbafori D Silué, Jürg Utzinger, Lukas K. Adiossan (599779)   +20 more
core   +1 more source

Effects of Artesunate on the Invasion of Lung Adenocarcinoma A549 Cells
and Expression of ICAM-1 and MMP-9

Chinese Journal of Lung Cancer, 2013
Background and objective Artesunate, an anti-malarial drug, elicits an inhibitory effect on pulmonary carcinoma. However, the mechanisms of artesunate activity on pulmonary carcinoma have not been completely elucidated.
Xianshan CHEN, Kunyuan HAN, Fengxia CHEN, Congming WU, Weiyi HUANG   +4 more
doaj   +1 more source

Artesunate shows potent anti-tumor activity in B-cell lymphoma

Journal of Hematology & Oncology, 2018
Background Although chemo-immunotherapy has led to an improved overall survival for most B-cell lymphoma types, relapsed and refractory disease remains a challenge. The malaria drug artesunate has previously been identified as a growth suppressor in some
Thea Kristin Våtsveen, Marit Renée Myhre, Chloé Beate Steen, Sébastien Wälchli, Ole Christian Lingjærde, Baoyan Bai, Pierre Dillard, Theodossis A. Theodossiou, Toril Holien, Anders Sundan, Else Marit Inderberg, Erlend B. Smeland, June Helen Myklebust, Morten P. Oksvold   +13 more
doaj   +1 more source

Chlorproguanil−Dapsone−Artesunate versus Artemether−Lumefantrine : a randomized, double-blind phase III trial in African children and adolescents with uncomplicated plasmodium falciparum malaria [PDF]

, 2009
Chlorproguanil−dapsone−artesunate (CDA) was developed as an affordable, simple, fixed-dose artemisinin-based combination therapy for use in Africa. This trial was a randomized parallel-group, double-blind, double-dummy study to compare CDA and artemether−
Peter A Winstanley, Pamba Allan, Guiguemdé, Robert, Stephan Duparc, Paula L Kirby, Esamai, Fabian, Ezedinachi, Emmanuel U, Ward, S.A., Umeh, Rich E., Borrmann Steffen, Winstanley Peter A., Kirby, Paula L., Kellam, Lynda, Premji, Z., Greenwood, Brian, Ward, Stephen A, Premji, Zul, Lynda Kellam, Ezedinachi Emmanuel U., Oguche, Stephen, Owusu-Agyei, S., Stephen Oguche, Greenwood Brian, Oguche Stephen, Owusu-Agyei Seth, Winstanley, Peter A, Oguche, S, Emmanuel U Ezedinachi, Pamba, Allan, Rich E Umeh, Greenwood, B., Umeh Rich E., Zul Premji, Kellam, L., Winstanley, P.A., Duparc, Stephan, Owusu-Agyei, Seth, Duparc Stephan, Guiguemdé Robert, Guiguemde, R., Ward, S. A., Umeh, Rich Enujioke, Allan Pamba, Ward, Steve, Fabian Esamai, Ezedinachi, Emmanuel U., Umeh, R.E., Stephen A Ward, Kellam Lynda, Premji Zul, Esamai Fabian, Duparc, S., Kirby Paula L., Sowunmi Akintunde, Kirby, Paula L, Brian Greenwood, Pamba, A., Kirby, P.L., Rénia, Laurent, Ward Stephen A., Borrmann, S., Seth Owusu-Agyei, Robert Guiguemdé, Akintunde Sowunmi, Sowunmi, Akintunde, Ezedinachi, E.U., Umeh, Rich E, Sowunmi, A., Oguche, S., Borrmann, Steffen, Esamai, F., Steffen Borrmann, Winstanley, Peter, Winstanley, Peter A.   +73 more
core   +1 more source

Oral activated charcoal prevents experimental cerebral malaria in mice and in a randomized controlled clinical trial in man did not interfere with the pharmacokinetics of parenteral artesunate. [PDF]

, 2010
BACKGROUND: Safe, cheap and effective adjunct therapies preventing the development of, or reducing the mortality from, severe malaria could have considerable and rapid public health impact.
Conway, David J, Owens, Benjamin MJ, Harparkash Kaur, Brian M J Foxwell, Sumariwalla, Percy F., Percy F Sumariwalla, Kevin J Tracey, Sant Muangnoicharoen, Paul M Kaye, Conway, David J., Ulloa, Luis, Kaye, Paul M., de Souza, J Brian, Muangnoicharoen, Sant, Luis Ulloa, David J Conway, Warhurst, David C., Tracey, Kevin J, Ward, Steve, Sumariwalla, Percy F, Michael Walther, Stephen A Ward, Ward, Stephen A, Uduak Okomo, Alexander, Neal D, Momodou Jasseh, Aziz, Naveed, Walther, Michael, Naveed Aziz, Tracey, Kevin J., Jasseh, Momodou, de Souza, Brian B., David C Warhurst, Kaur, Harparkash, Foxwell, Brian MJ, Warhurst, David C, Neal D Alexander, Owens, Benjamin M.J., Benjamin M J Owens, Okomo, Uduak, Foxwell, Brian M.J., J Brian de Souza, Alexander, Neal D., Kaye, Paul M   +43 more
core   +1 more source

Open-label comparative clinical study of chlorproguanil−dapsone fixed dose combination (Lapdap™) alone or with three different doses of artesunate for uncomplicated plasmodium falciparum malaria [PDF]

, 2008
The objective of this study was to determine the appropriate dose of artesunate for use in a fixed dose combination therapy with chlorproguanil−dapsone (CPG−DDS) for the treatment of uncomplicated falciparum ...
Peter A Winstanley, Nyirenda, Maggie, Kanjala, Maxwell K., Molyneux, Malcolm, Sam Dunyo, Stephan Duparc, Paula L Kirby, Winstanley Peter A., Kirby, Paula L., Blencowe, Hannah, Daniel G Wootton, Woessner, Mary, Thomas Kanyok, Stephen Ward, Opara, Hyginus, Molyneux Malcolm, Winstanley, Peter A, Wootton Daniel G., Maggie Nyirenda, Ward, Stephen, Dunyo, Sam, Giancarlo A Biagini, Kanjala, Maxwell K, Nyirenda Maggie, Kanyok Thomas, Maxwell K Kanjala, Opara Hyginus, Duparc, Stephan, Kanyok, Thomas, Queen Dube-Mbeye, Duparc Stephan, Malcolm Molyneux, Neate, Colin, Biagini, Giancarlo A, Biagini Giancarlo A., Ward Stephen, Kirby Paula L., Wootton, Daniel G., Wootton, Daniel G, Kirby, Paula L, Hannah Blencowe, Mary Woessner, Kanjala Maxwell K., Molyneux, Malcolm E., Biagini, Giancarlo A., Woessner Mary, Dube-Mbeye Queen, Colin Neate, Hyginus Opara, Neate Colin, Blencowe Hannah, Dunyo Sam, Winstanley, Peter, Dube-Mbeye, Queen   +53 more
core   +1 more source