Results 11 to 20 of about 18,290 (191)

Cost-effectiveness of parenteral artesunate for treating children with severe malaria in sub-Saharan Africa [PDF]

Bulletin of the World Health Organization, 2011
OBJECTIVE: To explore the cost-effectiveness of parenteral artesunate for the treatment of severe malaria in children and its potential impact on hospital budgets. METHODS: The costs of inpatient care of children with severe malaria were assessed in four
Yoel Lubell, Arthorn Riewpaiboon, Arjen M Dondorp, Lorenz von Seidlein, Olugbenga A Mokuolu, Margaret Nansumba, Samwel Gesase, Alison Kent, George Mtove, Rasaq Olaosebikan, Wirichada Pan Ngum, Caterina I Fanello, Ilse Hendriksen, Nicholas PJ Day, Nicholas J White, Shunmay Yeung   +15 more
doaj   +2 more sources

Artesunate-, sulfadoxine-, and pyrimethamine-induced cardiotoxicity

BLDE University Journal of Health Sciences, 2016
Here, we report oral artesunate, sulphadoxine and pyrimethamine (sp) induced cardio toxicity case in a female patient. Artesunate is a highly efficacious and relatively safe antimalarial drug.
Divya Goel, Shafiqa Aslam, Rani Walia, Akshay Sadhotra   +3 more
doaj   +2 more sources

Simultaneous Spectrophotometric Estimation of Artesunate and Mefloquine [PDF]

Journal of Chemistry, 2013
A simple, rapid, precise, and accurate UV-visible spectrophotometric method has been developed for the simultaneous determination of Artesunate in combination with Mefloquine. For developing the method, methanol was used as a solvent.
T. M. Kalyankar, R. B. Kakade, M. S. Attar, A. R. Kamble   +3 more
doaj   +2 more sources

Stimulation of Suicidal Erythrocyte Death by Artesunate

Cellular Physiology and Biochemistry, 2014
Background: The artemisinin derivative artesunate is effective in the treatment of severe malaria and is considered for the treatment of malignancy. Artesunate triggers tumor cell apoptosis, an effect at least in part mediated by mitochondria.
Kousi Alzoubi, Salvatrice Calabrò, Rosi Bissinger, Majed Abed, Caterina Faggio, Florian Lang   +5 more
doaj   +2 more sources

Severe <i>Plasmodium vivax</i> Malaria Complicated by Secondary Hemophagocytic Lymphohistiocytosis, Disseminated Intravascular Coagulation, and Acute Pancreatitis: A Case Report. [PDF]

Clin Case Rep
ABSTRACT Plasmodium vivax (P. vivax) malaria, once regarded as a comparatively benign infection, is increasingly recognized as a cause of severe, potentially life‐threatening multisystem disease. Concurrent secondary hemophagocytic lymphohistiocytosis (HLH), disseminated intravascular coagulation (DIC), and acute pancreatitis complicating P.
Nafian T, Azad MAK, Murshed KM, Aftab KA, Shahriar R, Faisal AA.   +5 more
europepmc   +2 more sources

A Pilot Study Evaluating the Effect of Artesunate on Glymphatic-Related Fluid Transport in Parkinson's Disease Mouse Models In Vivo and Ex Vivo. [PDF]

CNS Neurosci Ther
Artesunate (ART) treatment was associated with enhanced glymphatic CSF‐ISF exchange in both wild‐type (WT) and A53T mouse models of Parkinson's disease, with regional differences observed by dynamic MRI. In A53T mice, ART was associated with restoration of AQP4 polarization and reduced α‐syn levels in the SN.
Han WT, Lu WH, Xu H, Xie GH, Cao Y, Wu XY, Qiu F, Fu T.   +7 more
europepmc   +2 more sources

Artesunate acts through cytochrome c to inhibit growth of pediatric AML cells

Scientific Reports, 2023
Artesunate is a derivative of artemisinin, an active compound isolated from Artemisia annua which has been used in Traditional Chinese Medicine and to treat malaria worldwide. Artemisinin derivatives have exhibited anti-cancer activity against both solid
Kristen S. Hill, Erin E. Schuler, Sally R. Ellingson, Jill M. Kolesar   +3 more
doaj   +1 more source

Integrated Bioinformatics Analysis Identifies FCER1G, IL1R2, and BST1 as Diagnostic Biomarkers and Therapeutic Targets in Sepsis. [PDF]

J Clin Lab Anal
Integrative bioinformatics and experimental validation of FCER1G, IL1R2, and BST1 as biomarkers and therapeutic targets in neonatal sepsis. ABSTRACT Background Sepsis remains difficult to diagnose since blood culture has low sensitivity and current biomarkers lack sufficient specificity.
Li J, Xiu G, Liu P, Chen X, Zhou K, Yang Y.   +5 more
europepmc   +2 more sources

Artemisinin resistance in Plasmodium falciparum malaria. [PDF]

, 2009
BACKGROUND: Artemisinin-based combination therapies are the recommended first-line treatments of falciparum malaria in all countries with endemic disease.
Yi, Poravuth, Singhasivanon, Pratap, Day, Nicholas PJ, Ariey, Frederic, Lindegardh, Niklas, Lim, Pharath, Dondorp, Arjen M, Ringwald, Pascal, Socheat, Duong, Hanpithakpong, Warunee, Silamut, Kamolrat, Lwin, Khin Maung, Imwong, Mallika, Phyo, Aung Phae, Das, Debashish, Lee, Sue J, Herdman, Trent, White, Nicholas J, Chotivanich, Kesinee, Yeung, Shunmay, Tarning, Joel, Nosten, François, An, Sen Sam   +22 more
core   +2 more sources

Assessment of quantitative and semi-quantitative biological test methods of artesunate in vitro

Parasite, 2022
Artesunate is the current most potent antimalarial drug widely used for the treatment of malaria. Considering the emergence of artemisinin resistance, several situations may require a simple method for artesunate quantification.
Kouakou Yobouet Ines, Omorou Roukayatou, Said Ibrahim Bin, Lavoignat Adeline, Bonnot Guillaume, Bienvenu Anne-Lise, Picot Stéphane   +6 more
doaj   +1 more source