Results 41 to 50 of about 75,356 (295)

DNA methylation of selected tumor suppressor genes in endometrial hyperplasia

Biomedical Papers
Aims. To investigate DNA methylation of specific gene promoters in endometrial hyperplasia compared to normal endometrial tissue. Materials and Methods.
Ondrej Dvorak, Munachiso Ndukwe, Marcela Slavickova, Jan Laco, Jiri Spacek   +4 more
doaj   +1 more source

Atypical Ductal Hyperplasia at the Margin of Lumpectomy Performed for Early Stage Breast Cancer: Is there Enough Evidence to Formulate Guidelines? [PDF]

, 2012
Background. Negative margins are associated with a reduced risk of ipsilateral breast tumor recurrence (IBTR) in women with early stage breast cancer treated with breast conserving surgery (BCS).
Baker, Jennifer L, Blair, Sarah L, Hasteh, Farnaz   +2 more
core   +3 more sources

Prevalence of incidental breast cancer and precursor lesions in autopsy studies: A systematic review and meta-analysis [PDF]

, 2017
Background Autopsy studies demonstrate the prevalence pool of incidental breast cancer in the population, but estimates are uncertain due to small numbers in any primary study.
Barratt, Alexandra, Bell, Katy J L, Del Mar, Chris, Glasziou, Paul, Thomas, Elizabeth T, Wright, Gordon   +5 more
core   +2 more sources

Changes in mRNA expression of oncogenesis driver genes in atypical ductal breast hyperplasia

Опухоли женской репродуктивной системы
Background. Atypical ductal hyperplasia is a relatively common breast lesion that increases the risk of breast cancer by 3.5 to 5 times. Genomic rearrangements underlying the development of atypical proliferative lesions and breast cancer lead to gene ...
O. V. Burmenskaya, V. V. Kometova, A. A. Smetnik, V. V. Rodionov, D. Yu. Trofimov, L. A. Ashrafyan, G. T. Sukhikh   +6 more
doaj   +1 more source

Digital morphometry of cytologic aspirate endometrial samples [Digitalna morfometrijska analiza citoloških uzoraka aspirata endometrija] [PDF]

, 2010
Unlike cervical cytology, morphological cytology criteria in the differential diagnosis of endometrium have not yet been clearly defined, and methods to allow for more precise evaluation of endometrium status have been searched for.
Babić, Damir, Barišić, Ana, Božikov, Jadranka, Ilić-Forko, Jadranka, Jurič, Danijela, Mahovlić, Vesna, Ovanin-Rakić, Ana, Rajhvajn, Sanda, Šamija Projić, Ivana, Škopljanac-Mačina, Lada, Škrablin-Kučić, Snježana   +10 more
core  

Hyperandrogenemia Induces Trophoblast Ferroptosis and Early Pregnancy Loss in Patients With PCOS via CMA‐Dependent FTH1 Degradation

Advanced Science, EarlyView.
In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou, Weijie Yang, Na Liu, Qing Liu, Jiamin Jin, Chenqiong Zhao, Xiaoying Jin, Miao Gui, Haiyan Zhu, Songying Zhang, Yinli Zhang   +10 more
wiley   +1 more source

Diagnostic accuracy of hysteroscopy vs dilation and curettage (D&C) for atypical endometrial hyperplasia in patients performing hysterectomy or serial follow-up

Clinical and Experimental Obstetrics & Gynecology, 2022
Background: Endometrial hyperplasia (EH) is considered a heterogeneous pre-neoplastic clinical entity characterized by an abnormal glandular proliferation, with less than half of the tissue area occupied by the stroma. The aim of this retrospective study
Luigi Nappi, Stefano Angioni, Vincenzo De Feo, Pantaleo Greco, Guglielmo Stabile, Francesca Greco, Maurizio Nicola D'Alterio, Felice Sorrentino   +7 more
doaj   +1 more source

Characterizing Stage‐Specific Cellular Dynamics and Microenvironmental Remodeling in Lung Adenocarcinoma by Single‐Cell RNA Sequencing

Advanced Science, EarlyView.
This study integrated early‐stage patient specimens with publicly available datasets encompassing non‐malignant lung tissues and advanced‐stage LUAD through single‐cell sequencing, revealing a dynamically remodeled tumor microenvironment characterized by a hypoxia‐adapted malignant subset (C5), immunosuppressive LGMN+ macrophages, STAT1‐driven ...
Bomiao Qing, Xiaolan Li, Xiang He, Junyi Wang, Yi Yang, Manling Jiang, Bingbing Yan, Lei Zhang, Anying Xiong, Qin Ran, Guoping Li   +10 more
wiley   +1 more source

Ibuprofen Induces Reduction of the Proliferation-Seeking Radiotracer Tc-(V)DMSA Uptake in Severe Epithelial Breast Hyperplasia without Atypia

Molecular Imaging, 2010
The purpose of this study was to investigate if ibuprofen intake can influence mammary uptake of the proliferation-seeking radiotracer technetium 99m–pentavalent dimercaptosuccinic acid ( 99m Tc-(V)DMSA) in women with severe epithelial and atypical ...
Vassilios Papantoniou, Angeliki Tsaroucha, Pipitsa Valsamaki, Spyridon Tsiouris, Evangelia Sotiropoulou, Theodore Karianos, Spyridon Marinopoulos, Athina Fothiadaki, Maria Sotiropoulou, Aikaterini Archontaki, Konstantinos Syrgiannis, Konstantinos Dimitrakakis, Aris Antsaklis   +12 more
doaj   +1 more source

Conservative Management of Atypical Endometrial Hyperplasia and Early Endometrial Cancer in Childbearing Age Women

Medicina, 2022
Total hysterectomy and bilateral adnexectomy is the standard treatment for atypical endometrial hyperplasia and early-stage endometrial cancer. However, the recommended surgical treatment precludes future pregnancy when these conditions are diagnosed in ...
Stefano Uccella, Pier Carlo Zorzato, Susan Dababou, Mariachiara Bosco, Marco Torella, Andrea Braga, Matteo Frigerio, Barbara Gardella, Stefano Cianci, Antonio Simone Laganà, Massimo Piergiuseppe Franchi, Simone Garzon   +11 more
doaj   +1 more source