Hyperbolic Molecular Representation Learning for Drug Repositioning [PDF]
Learning accurate drug representations is essential for task such as computational drug repositioning. A drug hierarchy is a valuable source that encodes knowledge of relations among drugs in a tree-like structure where drugs that act on the same organs, treat the same disease, or bind to the same biological target are grouped together.
arxiv
AMFPMC -- An improved method of detecting multiple types of drug-drug interactions using only known drug-drug interactions [PDF]
Adverse drug interactions are largely preventable causes of medical accidents, which frequently result in physician and emergency room encounters. The detection of drug interactions in a lab, prior to a drug's use in medical practice, is essential, however it is costly and time-consuming.
arxiv
Purpose: Drug allergy documentation in the patient medical record varies in level of detail, and drug intolerances are often inappropriately documented as an allergy in the medical record. A pilot study was conducted to determine the impact of a pharmacy-
Crystal Deas, C. Whitney White
doaj +1 more source
Social Media Analysis for Product Safety using Text Mining and Sentiment Analysis [PDF]
The growing incidents of counterfeiting and associated economic and health consequences necessitate the development of active surveillance systems capable of producing timely and reliable information for all stake holders in the anti-counterfeiting fight. User generated content from social media platforms can provide early clues about product allergies,
arxiv +1 more source
Rising drug allergy alert overrides in electronic health records: an observational retrospective study of a decade of experience [PDF]
Objective There have been growing concerns about the impact of drug allergy alerts on patient safety and provider alert fatigue. The authors aimed to explore the common drug allergy alerts over the last 10 years and the reasons why providers tend to ...
Bates, D.W.+10 more
core +2 more sources
Mycoplasma infection may lower the threshold for drug allergy in particular patients. We present a case of drug reaction with eosinophilia and systemic symptoms (DRESS), with drug etiology and non-drug etiology (Mycoplasma infection).
Guy Shalom, Raed Khoury, Amir Horev
doaj +1 more source
NeuroCADR: Drug Repurposing to Reveal Novel Anti-Epileptic Drug Candidates Through an Integrated Computational Approach [PDF]
Drug repurposing is an emerging approach for drug discovery involving the reassignment of existing drugs for novel purposes. An alternative to the traditional de novo process of drug development, repurposed drugs are faster, cheaper, and less failure prone than drugs developed from traditional methods.
arxiv
'Cephalosporin allergy' label is misleading [PDF]
Penicillins and cephalosporins can cause a similar spectrum of allergic reactions at a similar rate. Cross-reactive allergy between penicillins and cephalosporins is rare, as is cross-reaction within the cephalosporin group. Patients should therefore not
Katelaris, Constance H. (R12307)+2 more
core +1 more source
Medical Knowledge Graph QA for Drug-Drug Interaction Prediction based on Multi-hop Machine Reading Comprehension [PDF]
Drug-drug interaction prediction is a crucial issue in molecular biology. Traditional methods of observing drug-drug interactions through medical experiments require significant resources and labor. This paper presents a medical knowledge graph question answering model, dubbed MedKGQA, that predicts drug-drug interaction by employing machine reading ...
arxiv +1 more source
Allergic disorders and their risk factors in primary Sjögren's syndrome
Objective: This study aimed to evaluate the prevalence of allergic disorders in patients with primary Sjögren's syndrome (pSS), compare it with that of patients with rheumatoid arthritis (RA), and examine the risk factors in patients with pSS.
Misako Higashida-Konishi, MD, PhD+6 more
doaj