Results 41 to 50 of about 178,279 (340)

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

Molecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed, Lucas Mani, Muhammad Bilal Mirza, Ashtyn McAdoo, Takahito Kondo, Hidenori Tanaka, Nicole Meeks, Eben Rosenthal, Marisa Hom   +8 more
wiley   +1 more source

Evaluation and modification of tumor cell isolation techniques from malignant effusions for rapid drug sensitivity testing

Molecular Oncology, EarlyView.
Non‐small cell lung cancer targeted treatment is limited to a few known genetic alterations, with few alternatives in advanced treatment lines. To direct treatment decisions by drug sensitivity testing (DST), this study compared several methods for tumor cell isolation from malignant effusions, pointing to repeated CD45+ cell depletion for effective ...
Navit Mooshayef, Hana Barhom, Sumit Chatterji, Netta Hecht, Oran Warhaftig, Iris Kamer, Oranit Zadok, Jair Bar, Limor Broday, Amir Onn, Michael Peled   +10 more
wiley   +1 more source

Fertility Preservation in Female Patients with Cancer Part II: Royan Institute Clinical Practice Guideline for Girls and Women with Cancer; A Review Study [PDF]

International Journal of Fertility and Sterility
The fertility preservation (FP) is a paramount concern for oncology patients and should be regarded as an essentialcomponent of their overall cancer management strategy. The magnitude of this issue has been recognized in FPguidelines. The formulation and
Azar Yahyaei, Esmat Mashhadi Meighani, Firouzeh Ghaffari   +2 more
doaj   +1 more source

mRNA Expression of VEGF and Its Receptors in Fallopian Tubes of Women with Ectopic Pregnancies [PDF]

International Journal of Fertility and Sterility, 2015
Background Establishment of viable pregnancy requires embryo implantation and placentation. Ectopic pregnancy (EP) is a pregnancy complication which occurs when an embryo implants outside of the uterine cavity, most often in a fallopian tube.
Nafise Zarezade, Samane Saboori Darabi, Fariba Ramezanali, Elham Amirchaghmaghi, Gholamreza Khalili, Reza Aflatoonian   +5 more
doaj   +1 more source

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

Molecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez, Asieh Naderi, Kim‐Tuyen Huynh‐Dam, Vitali Sikirzhytski, Ioulia Chatzistamou, Hippokratis Kiaris   +5 more
wiley   +1 more source

Fertility Preservation in Female Patients with Cancer. Part I: Challenges and Future Prospects in Developing Countries; A Narrative Review Study [PDF]

International Journal of Fertility and Sterility
While international guidelines on oncofertility practice have been published in developed countries, there is limitedinformation available on oncofertility practice in developing countries, which often face limitations in their cancerhealth support ...
Esmat Mashhadi Meighani, Azar Yahyaei, Firouzeh Ghaffari   +2 more
doaj   +1 more source

Genetic variants of CYP2C9 and IL-6 on female infertility [PDF]

, 2017
AIM: To study the polymorphic variants in CYP2C9*2*3 and the C-174G promoter polymorphism of the IL-6 gene on Infertile Women.BACKGROUND: - Infertility affects 15–20% of couples worldwide.
Alves, H., Barros, A., Botelho, M.C., Cardoso, R., da Silva, J.M., Gonçalves, A., Oliveira, C., Xavier, P.   +7 more
core  

What is the excess risk of infertility in women after genital chlamydia infection? A systematic review of the evidence [PDF]

, 2008
Methods: Twelve databases were searched, limited to peer-reviewed literature published from January 1970 to September 2007. Conference abstracts and reference lists from reviews published since 2000 and from key articles were hand-searched.
Goldberg, D.J., Hart, G., Reid, M., Scoular, A., Wallace, L.A., Wilson, P.   +5 more
core   +1 more source

Knockout of the mitoribosome rescue factors Ict1 or Mtrfr is viable in zebrafish but not mice: compensatory mechanisms underlying each factor's loss

FEBS Open Bio, EarlyView.
Mitochondria contain two mitoribosome rescue factors, ICT1 and MTRFR (C12orf65). ICT1 also functions as a mitoribosomal protein in mice and humans, and its loss is lethal. Although Mtrfr knockout mice could not be generated, knockout zebrafish lines for ict1 and mtrfr were established.
Nobukazu Nameki, Chika Tomisawa, Soichiro Hoshino, Hidehiko Shimizu, Masashi Abe, Sho Arai, Kanako Kuwasako, Naoki Asakawa, Yusuke Inoue, Takuro Horii, Izuho Hatada, Masakatsu Watanabe   +11 more
wiley   +1 more source

Increasing The Number of Embryos Transferred from Two to Three, Does not Increase Pregnancy Rates in Good Prognosis Patients [PDF]

International Journal of Fertility and Sterility, 2015
Background To compare the pregnancy outcomes after two embryos versus three embryos transfers (ETs) in women undergoing in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) cycles.
Mahnaz Ashrafi, Tahereh Madani, Mina Movahedi, Arezoo Arabipoor, Leili Karimian, Elaheh Mirzaagha, Mohammad Chehrazi   +6 more
doaj   +1 more source