Results 41 to 50 of about 568,627 (261)

Monoclonal antibodies against human astrocytomas and their reactivity pattern [PDF]

, 1987
The establishment of hybridomas after fusion of X63-Ag8.653 mouse myeloma cells and splenocytes from mice hyperimmunized against human astrocytomas is presented. The animals were primed with 5 × 106 chemically modified uncultured or cultured glioma cells.
B. Martin, Bourdon, Bullard, Bullard, Carrel, Coakham, Coakham, D. Stavrou, De Muralt, E. Keiditsch, Epenetos, F. Schmidberger, I. Funke, Jonak, K. Bise, Kearney, Kemshead, Krajewski, Köhler, Lanier, Posner, R. Kurrle, Roholl, Schnegg, Seeger, Sikora, Stavrou, Stavrou, Stavrou, Stavrou, Stavrou, Stavrou, Stavrou, Taub, U. Stocker, W. Eisenmenger, Wikstrand   +36 more
core   +1 more source

Specific anti‐glioma targeted‐delivery strategy of engineered small extracellular vesicles dual‐functionalised by Angiopep‐2 and TAT peptides

Journal of Extracellular Vesicles, 2022
Glioma is one of the primary malignant brain tumours in adults, with a poor prognosis. Pharmacological reagents targeting glioma are limited to achieve the desired therapeutic effect due to the presence of blood‐brain barrier (BBB).
Zhanchi Zhu, Yuanxin Zhai, Ying Hao, Quanwei Wang, Fang Han, Wenlong Zheng, Jing Hong, Leisha Cui, W. Jin, Sancheng Ma, Lingyan Yang, G. Cheng   +11 more
semanticscholar   +1 more source

Gene Expression Profiling Stratifies IDH-Wildtype Glioblastoma With Distinct Prognoses

Frontiers in Oncology, 2019
Objectives: In the present study, we aimed to determine the candidate genes that may function as biomarkers to further distinguish patients with isocitrate dehydrogenase (IDH)-wildtype glioblastoma (GBM), which are heterogeneous with respect to clinical ...
Yu-Qing Liu, Yu-Qing Liu, Fan Wu, Fan Wu, Jing-Jun Li, Jing-Jun Li, Yang-Fang Li, Yang-Fang Li, Xing Liu, Xing Liu, Zheng Wang, Zheng Wang, Rui-Chao Chai, Rui-Chao Chai   +13 more
doaj   +1 more source

Molecular and Genetic Determinants of Glioma Cell Invasion. [PDF]

, 2017
A diffusely invasive nature is a major obstacle in treating a malignant brain tumor, "diffuse glioma", which prevents neurooncologists from surgically removing the tumor cells even in combination with chemotherapy and radiation.
Kato, Yoichiro, Masui, Kenta, Mischel, Paul S, Sawada, Tatsuo, Shibata, Noriyuki   +4 more
core   +2 more sources

Endothelin receptor B antagonists decrease glioma cell viability independently of their cognate receptor [PDF]

, 2008
Background: Endothelin receptor antagonists inhibit the progression of many cancers, but research into their influence on glioma has been limited. Methods: We treated glioma cell lines, LN-229 and SW1088, and melanoma cell lines, A375 and WM35 ...
A Bagnato, A Bagnato, AV Budanov, D Salani, ER Levin, F Spinella, G Egidy, G Pan, H Peeters, H Walczak, HT Adler, J Eberle, J Nelson, JB Nelson, JD Stiles, Jennifer P Montgomery, JP Sheridan, JR Wu-Wong, K Ishikawa, K Kikuchi, K Takahashi, L Rosano, L Rosano, M Matsumoto, M Nagane, M Sone, M Takekawa, MC Hollander, N Kitagawa, Paul H Patterson, Q Zhan, Q Zhan, R Lahav, R Lahav, S He, S Jin, S Jin, S Velasco-Miguel, SP Harland, U Pagotto, V Naidoo, XW Wang, Y Berger   +42 more
core   +3 more sources

Vorasidenib, a Dual Inhibitor of Mutant IDH1/2, in Recurrent or Progressive Glioma; Results of a First-in-Human Phase I Trial

Clinical Cancer Research, 2021
Purpose: Lower grade gliomas (LGGs) are malignant brain tumors. Current therapy is associated with short- and long-term toxicity. Progression to higher tumor grade is associated with contrast enhancement on MRI.
I. Mellinghoff, M. Penas-Prado, K. Peters, H. Burris, E. Maher, F. Janku, G. Cote, M. I. de la Fuente, Jennifer L. Clarke, B. Ellingson, Saewon Chun, R. Young, Hua Liu, S. Choe, Min Lu, K. Le, Islam Hassan, L. Steelman, S. Pandya, T. Cloughesy, P. Wen   +20 more
semanticscholar   +1 more source

Axitinib induces senescence-associated cell death and necrosis in glioma cell lines: The proteasome inhibitor, bortezomib, potentiates axitinib-induced cytotoxicity in a p21(Waf/Cip1) dependent manner. [PDF]

, 2017
Glioblastoma is associated with a poor overall survival despite new treatment advances. Antiangiogenic strategies targeting VEGF based on tyrosine kinase inhibitors (TKIs) are currently undergoing extensive research for the treatment of glioma.
Amantini, C, BERNARDINI, Giovanni, CARDINALI, CLAUDIO, MORELLI, MARIA BEATRICE, Nabissi, M, SANTONI, Angela, Santoni, G., Santoni, M   +7 more
core   +1 more source

An online survival predictor in glioma patients using machine learning based on WHO CNS5 data

Frontiers in Neurology, 2023
BackgroundThe World Health Organization (WHO) CNS5 classification system highlights the significance of molecular biomarkers in providing meaningful prognostic and therapeutic information for gliomas.
Liguo Ye, Lingui Gu, Zhiyao Zheng, Zhiyao Zheng, Zhiyao Zheng, Xin Zhang, Hao Xing, Xiaopeng Guo, Xiaopeng Guo, Wenlin Chen, Yaning Wang, Yuekun Wang, Tingyu Liang, Hai Wang, Yilin Li, Yilin Li, Shanmu Jin, Shanmu Jin, Yixin Shi, Yixin Shi, Delin Liu, Delin Liu, Tianrui Yang, Tianrui Yang, Qianshu Liu, Qianshu Liu, Congcong Deng, Yu Wang, Yu Wang, Wenbin Ma, Wenbin Ma   +30 more
doaj   +1 more source

Cannabidiol inhibits human glioma by induction of lethal mitophagy through activating TRPV4

Autophagy, 2021
Glioma is the most common primary malignant brain tumor with poor survival and limited therapeutic options. The non-psychoactive phytocannabinoid cannabidiol (CBD) has been shown to be effective against glioma; however, the molecular target and mechanism
Tengfei Huang, Tianqi Xu, Yangfan Wang, Yan Zhou, Dandan Yu, Zhiyuan Wang, Linfang He, Zhangpeng Chen, Yaliang Zhang, Don Davidson, Yuyuan Dai, C. Hang, Xiangyu Liu, C.-Q. Yan   +13 more
semanticscholar   +1 more source

Silencing expression of PHF14 in glioblastoma promotes apoptosis, mitigates proliferation and invasiveness via Wnt signal pathway

Cancer Cell International, 2019
Background The plant homeodomain (PHD) finger protein 14 (PHF14) is a vital member of PHD finger protein families. Abnormal expression of PHF14 has been identified in various cancers and is known to be implicated in the pathogenesis of tumors. This study
Shuai Wu, Chen Luo, Fengjiao Li, N. U. Farrukh Hameed, Qiuyan Jin, Jie Zhang   +5 more
doaj   +1 more source