Results 41 to 50 of about 617,967 (333)

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

Molecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte, Osheen Sharma, Laura Leuenberger, Emelie Wallin, Josefin Fernebro, Päivi Östling, Rebecka Bergström, Johan Lindberg, Ulrika Joneborg, Olli Kallioniemi, Brinton Seashore‐Ludlow   +10 more
wiley   +1 more source

Effect of the over-ageing treatment on the mechanical properties of AA2024 aluminum alloy. [PDF]

, 2012
The evolution of the hardness of the over-ageing AA2024 alloy scale was followed by measurements of Vickers hardness. The nanoindentation is adapted to the determination of elastoplastic properties (hardness and Young’s modulus) of the matrix and also of
Abrudeanu, Marioara, Alexis, Joël, Lacroix, Loïc, Petit, Jacques-Alain, Radutoiu, Nicoleta, Rizea, Vasile, Vulpe, Sanda   +6 more
core  

A new approach to local hardness

, 2011
The applicability of the local hardness as defined by the derivative of the chemical potential with respect to the electron density is undermined by an essential ambiguity arising from this definition. Further, the local quantity defined in this way does
Ayers, Ayers, Ayers, Ayers, Becke, Becke, Berkowitz, Borgoo, Broadus, Cedillo, Chattaraj, Chattaraj, Chattaraj, Chermette, Clarke, De Proft, De Proft, F. De Proft, Frisch, Fuentealba, Galván, Garza, Geerlings, Geerlings, Ghanty, Ghosh, Ghosh, Gál, Gál, Gál, Gál, Gál, Gál, Gál, Gál, Gázquez, Harbola, Hehre, Koenig, Langenaeker, Lee, Levedev, Liu, Liu, M. Torrent-Sucarrat, Melin, Meneses, Meneses, Mignon, Mignon, Mulliken, Nagy, Nagy, Olasz, Ozen, P. Geerlings, Parr, Parr, Parr, Parr, Pearson, Pearson, Pearson, Pearson, Perdew, Roy, Saha, Saha, Saha, Sanderson, Slater, T. Gál, Thomas, Torrent-Sucarrat, Torrent-Sucarrat, Torrent-Sucarrat, Torrent-Sucarrat, Torrent-Sucarrat, Torrent-Sucarrat, Torrent-Sucarrat, Torrent-Sucarrat, Uline, Uline, Vargas, Yang, Zhou   +85 more
core   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Effect of Severe Plastic Deformation on the Conductivity and Strength of Copper-Clad Aluminium Conductors

Metals, 2019
Aluminium rods with different copper sheath thicknesses were processed by severe plastic deformation at room temperature and then annealed, to join the constituent metals and produce a nanocrystalline microstructure.
Rimma Lapovok, Michael Dubrovsky, Anna Kosinova, Georgy Raab   +3 more
doaj   +1 more source

Effect of soya milk on nutritive, antioxidative, reological and textural properties of chocolate produced in a ball mill [PDF]

Hemijska Industrija, 2011
Chocolate is a complex rheological system in which non-fat cocoa particles and sugar particles are enveloped by crystal matrix of cocoa butter. Physical properties of chocolate depend on ingredient composition, method of production and properly ...
Zarić Danica B., Pajin Biljana S., Rakin Marica B., Šereš Zita I., Dokić Ljubica P., Tomić Jelena M.   +5 more
doaj   +1 more source

Conditional Hardness for Approximate Coloring

, 2005
We study the coloring problem: Given a graph G, decide whether $c(G) \leq q$ or $c(G) \ge Q$, where c(G) is the chromatic number of G. We derive conditional hardness for this problem for any constant $3 \le q < Q$.
Dinur, Irit, Mossel, Elchanan, Regev, Oded   +2 more
core   +3 more sources

Co‐overexpression of the caloric restriction‐induced mitochondrial factors PGC‐1α and MIPEP upregulates Phospho1 expression in adipocytes

FEBS Open Bio, EarlyView.
Caloric restriction that extends lifespan induces the expression of PGC‐1α and MIPEP in white adipose tissue. In this study, co‐overexpression of Pgc‐1α and Mipep upregulated the gene expression of PHOSPHO1. These findings provide new insights into mitochondria‐related mechanisms underlying the effects of caloric restriction in adipocytes.
Mamiko Ishimatsu, Kanari Taki, Asuka Hayami, Komachi Kato, Yuka Nozaki, Yuhei Mizunoe, Takumi Narita, Ryoichi Mori, Yoshikazu Higami, Masaki Kobayashi   +9 more
wiley   +1 more source

On the Hardness of a New Boron Phase, Orthorhombic {\gamma}-B28

, 2011
Measurements of the hardness of a new high-pressure boron phase, orthorhombic {\gamma}-B28, are reported. According to the data obtained, {\gamma}-B28 has the highest hardness (~50 GPa) of all known crystalline modifications of ...
A. R. Oganov, A.R. Oganov, B. F. Decke, B.E. Douglas, E. Amberger, H. Bolmgren, J.L. Hoard, M. Vlasse, O. O. Kurakevych, V. L. Solozhenko, V.L. Solozhenko   +10 more
core   +1 more source

Characterization of ribosome heterogeneity during endothelial to hematopoietic transition

FEBS Open Bio, EarlyView.
The panorama of ribosome heterogeneity during embryonic hematopoiesis has not yet been portrayed. In this study, utilizing dual‐omics data, the heterogenous dynamic of ribosome during endothelial‐to‐hematopoietic transition has been systemically described. Moreover, stage‐specific upregulation and peripheral localization of RPL27 and RACK1 in hemogenic
Xitong Tian, Di Liu, Bing Liu, Yu Lan, Jie Zhou   +4 more
wiley   +1 more source