Results 41 to 50 of about 115,102 (75)

Hegemonic structure of basic, clinical and patented knowledge on Ebola research: a US army reductionist initiative [PDF]

Journal of Translational Medicine (2015) 13:124, 2016
Background: In this paper, we present an approach to understand how the basic, clinical and patent knowledge on Ebola is organized and intercommunicated and what leading factor could be shaping the evolution of the knowledge translation process for this disease.
arxiv   +1 more source

Protein profiling in systemic sclerosis patients with different pulmonary complications using proteomic antibody microarray

Arthritis Research & Therapy
Background Pulmonary arterial hypertension (PAH) and interstitial lung disease (ILD) are leading causes of systemic sclerosis (SSc)-related death. In this study, we aimed to identify biomarkers for detecting SSc pulmonary complications that are mild and ...
Jing Huang, Honglin Zhu, Sijia Liu, Mengtao Li, Yisha Li, Hui Luo, Xiaoxia Zuo   +6 more
doaj   +1 more source

Clinical characteristics of patients with a family history of psoriasis: an observational epidemiological study in Chinese Han population

Frontiers in Medicine
IntroductionPsoriasis, a chronic inflammatory skin disease, is believed to be influenced by both genetic and environmental factors. Despite this understanding, the clinical epidemiological status of psoriasis patients with a family history of the disease
Lu Cao, Lu Cao, Lingyi Lu, Lingyi Lu, Yingzhe Yu, Yingzhe Yu, Huiying Zhou, Huiying Zhou, Bingjiang Lin, Bingjiang Lin   +9 more
doaj   +1 more source

Effectiveness of iguratimod as monotherapy or combined therapy in patients with rheumatoid arthritis: a systematic review and meta-analysis of RCTs

Journal of Orthopaedic Surgery and Research, 2021
Background This study aims to evaluate the efficacy and safety of the iguratimod (IGU) as monotherapy or combined therapy in patients with rheumatoid arthritis (RA) by using meta-analysis.
Chao-Jun Hu, Li Zhang, Shuang Zhou, Nan Jiang, Jiu-Liang Zhao, Qian Wang, Xin-Ping Tian, Xiao-Feng Zeng   +7 more
doaj   +1 more source

Ophthalmic involvement disparities in clinical characteristics of IgG4-related disease: a retrospective study of 573 patients

BMC Ophthalmology, 2021
Purpose To investigate the clinical manifestations of orbital involvement in a large cohort of Chinese patients with IgG4-related disease (IgG4-RD). Methods A total of 573 patients with IgG4-related disease were included.
Linyang Gan, Xuan Luo, Yunyun Fei, Linyi Peng, Jiaxin Zhou, Jieqiong Li, Hui Lu, Zheng Liu, Panpan Zhang, Xiaowei Liu, Wen Zhang   +10 more
doaj   +1 more source

Unraveling the Link between Periodontitis and Inflammatory Bowel Disease: Challenges and Outlook [PDF]

arXiv, 2023
Periodontitis and Inflammatory Bowel Disease (IBD) are chronic inflammatory conditions, characterized by microbial dysbiosis and hyper-immunoinflammatory responses. Growing evidence suggest an interconnection between periodontitis and IBD, implying a shift from the traditional concept of independent diseases to a complex, reciprocal cycle.
arxiv  

Pattern Analysis of Tandem Repeats in Nlrp1 [PDF]

arXiv, 2013
Pattern analysis of tandem repeats in gene is an indispensable computational approach to the understanding of the gene expression and pathogenesis of diseases. This research applied a computational motif model and database techniques to study the distribution of tandem repeats in Nlrp1 gene, which is a critical gene to detect the invading pathogens in ...
arxiv  

Lymphocyte repertoire selection and intracellular self/not-self discrimination: historical overview [PDF]

arXiv, 2014
Immunological self/not-self discrimination is conventionally seen as an extracellular event, involving interactions been receptors on T cells pre-educated to discriminate, and peptides bound to major histocompatibility complex proteins (pMHCs). Mechanisms by which not-self peptides might first be sorted intracellularly to distinguish them from the vast
arxiv  

Cell-free DNA: a metabolic byproduct with diagnostic and prognostic potential in rheumatic disorders

Frontiers in Pharmacology
The release of intracellular DNA into the extracellular area occurs via two pathways: cell death and active secretion by cells. The DNA, which is free in the extracellular space, is commonly known as Cell-Free DNA (cfDNA).
Fancheng Liu, Fancheng Liu, Yazhen Su, Yazhen Su, Xinling Liu, Li Zhao, Li Zhao, Zewen Wu, Zewen Wu, Yang Liu, Yang Liu, Liyun Zhang, Liyun Zhang   +12 more
doaj   +1 more source

A Review of Mathematical Models for Muscular Dystrophy: A Systems Biology Approach [PDF]

arXiv, 2016
Muscular dystrophy (MD) describes generalized progressive muscular weakness due to the wasting of muscle fibers. The progression of the disease is affected by known immunological and mechanical factors, and possibly other unknown mechanisms. These dynamics have begun to be elucidated in the last two decades.
arxiv