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Normalizing and denoising protein expression data from droplet-based single cell profiling
Nature Communications, 2022 Current single cell protein expression profiling approaches come with substantial measurement noise. Here the authors discover the sources of this noise and develop a denoising algorithm that improves data quality and downstream applications.
Matthew P. Mulè +2 more
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The Road Less Taken: Less Appreciated Pathways for Manipulating CD8+ T Cell Exhaustion
Frontiers in Immunology, 2022 Exhausted CD8+ T (Tex) cells are a distinct cell population that arise during persistent antigen exposure in the context of chronic infections and cancers.
Andrea C. Pichler +3 more
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Development of the Immune System [PDF]
Infectious Diseases in Obstetrics and Gynecology, 1997 The development of immune defense mechanisms begins early during fetal life but is not yet completed at birth. The earliest hematopoietic stem cells, which give rise to the lymphocytic and myelomonocytic cell lines, appear between the fourth and eight weeks postconception.
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Complexity in the immune system [PDF]
Computers & Chemical Engineering, 2005 25 pages, 12 ...
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The immune system in chickens , [PDF]
Avian Pathology, 1974 The most sophisticated feature of the immune system expressed in vertebrates is recognition of foreign molecules by distinct types of immunocompetent cells. Birds are the first vertebrates in which a clear dichotomy of the lymphoid system has been established: 1. Thymus-derived (T) lymphocytes, the effector cells in cell-mediated (immunity and 2. Bursa-
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IFN-mediated negative feedback supports bacteria class-specific macrophage inflammatory responses
eLife, 2019 Despite existing evidence for tuning of innate immunity to different classes of bacteria, the molecular mechanisms used by macrophages to tailor inflammatory responses to specific pathogens remain incompletely defined.
Rachel A Gottschalk +10 more
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Cell Reports, 2022 Summary: Biologically active small molecules can impart modulatory effects, in some cases providing extended long-term memory. In a screen of biologically active small molecules for regulators of tumor necrosis factor (TNF) induction, we identify several
Sinu P. John +13 more
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Microbiota in neuroinflammation and synaptic dysfunction: a focus on Alzheimer’s disease
Molecular Neurodegeneration, 2022 Background The implication of gut microbiota in the control of brain functions in health and disease is a novel, currently emerging concept.
Diane Bairamian +6 more
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OMiCC: An expanded and enhanced platform for meta-analysis of public gene expression data
STAR Protocols, 2022 Summary: OMiCC (OMics Compendia Commons) is a biologist-friendly web platform that facilitates data reuse and integration. Users can search over 40,000 publicly available gene expression studies, annotate and curate samples, and perform meta-analysis ...
Candace C. Liu +5 more
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Immune System as a Sensory System
International Journal of Biomedical Science, 2010 As suggested by the well-known gestalt concept the immune system can be regarded as an integrated complex system, the functioning of which cannot be fully characterized by the behavior of its constituent elements. Similar approaches to the immune system in particular and sensory systems in general allows one to discern similarities and differences in ...
Igor M, Dozmorov, D, Dresser
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