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Adaptive Immunity and Inflammation [PDF]
International Journal of Inflammation, 2015 Inflammation is part of a complex biological response to injury as a result of different stimuli such as pathogens, damaged cells, or irritants. Local signals at the sites of inflammation mediate rapid cells mobilization and recruitment and dictate differentiation programs whereby these cells drive clearance of “inflammatory inducers” and promote ...
Brancaleone Vincenzo +3 more
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Adaptive immunity in the neuroinflammation of Alzheimer’s disease [PDF]
Chinese Medical Journal. Alzheimer’s disease (AD) is the most common cause of dementia and is a growing public health challenge. Neuroinflammation has been proposed as a prominent pathological feature of AD and has traditionally been attributed to the innate immune system ...
Hanchen Liu +4 more
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Adaptive Immunity in Pregnancy [PDF]
, 2021 One of the most remarkable features of reproductive biology is the fact that a healthy woman can successfully carry her genetically disparate conceptus to full term, without immune rejection. The juxtaposition of the placenta and decidua creates what is referred to as the ‘fetal-maternal interface’, where placental trophoblasts of fetal origin and ...
Piccinni MP, Saito S, Robertson SA
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eLife, 2023 Regulatory T cells (Tregs) are indispensable for maintaining self-tolerance by suppressing conventional T cells. On the other hand, Tregs promote tumor growth by inhibiting anticancer immunity.
Oksana Tsyklauri +13 more
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Frontiers in Immunology, 2022 Mature T cells are selected for recognizing self-antigens with low to intermediate affinity in the thymus. Recently, the relative differences in self-reactivity among individual T-cell clones were appreciated as important factors regulating their fate ...
Darina Paprckova +22 more
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Pinpointing the tumor-specific T cells via TCR clusters
eLife, 2022 Adoptive cell transfer (ACT) is a promising approach to cancer immunotherapy, but its efficiency fundamentally depends on the extent of tumor-specific T cell enrichment within the graft. This can be estimated via activation with identifiable neoantigens,
Mikhail M Goncharov +12 more
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Measuring Intratumoral Heterogeneity of Immune Repertoires
Frontiers in Oncology, 2020 There is considerable clinical and fundamental value in measuring the clonal heterogeneity of T and B cell expansions in tumors and tumor-associated lymphoid structures—along with the associated heterogeneity of the tumor neoantigen landscape—but such ...
Diana Vladimirovna Yuzhakova +30 more
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Adaptive Immunity in Hypertension [PDF]
Current Hypertension Reports, 2019 In recent years, a vast body of evidence has accumulated indicating the role of the immune system in the regulation of blood pressure and modulation of hypertensive pathology. Numerous cells of the immune system, both innate and adaptive immunity, have been indicated to play an important role in the development and maintenance of hypertension.
Mikolajczyk, Tomasz P., Guzik, Tomasz J.
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Human rhinovirus promotes STING trafficking to replication organelles to promote viral replication
Nature Communications, 2022 Evidence exists that the typically antiviral signaling mediator STING is, counterintuitively, needed for optimal human rhinovirus infection. Here the authors confirm this finding and show how human rhinovirus can reduce stored Ca2+ levels to drive this ...
Martha Triantafilou +11 more
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Frontiers in Oncology, 2020 Substantial effort is being invested in the search for peripheral or intratumoral T cell receptor (TCR) repertoire features that could predict the response to immunotherapy.
Ekaterina A. Zhigalova +19 more
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