Results 1 to 10 of about 22,495,324 (170)

Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer

Nature, 2023
Pancreatic ductal adenocarcinoma (PDAC) is lethal in 88% of patients^ 1 , yet harbours mutation-derived T cell neoantigens that are suitable for vaccines ^ 2 , 3 .
Luis A. Rojas, Z. Sethna, K. Soares, C. Olcese, Nan Pang, Erin Patterson, J. Lihm, N. Ceglia, Pablo Guasp, A. Chu, Rebecca Yu, A. Chandra, Theresa Waters, J. Ruan, M. Amisaki, Abderezak Zebboudj, Z. Odgerel, George Payne, E. Derhovanessian, Felicitas Müller, I. Rhee, Mahesh Yadav, A. Dobrin, M. Sadelain, M. Łuksza, Noah Cohen, Laura A Tang, O. Basturk, M. Gönen, S. Katz, R. Do, A. Epstein, Parisa Momtaz, W. Park, R. Sugarman, A. Varghese, Elizabeth S. Won, A. Desai, Alice C. Wei, M. D'Angelica, T. Kingham, I. Mellman, T. Merghoub, J. Wolchok, U. Şahin, O. Türeci, B. Greenbaum, W. Jarnagin, J. Drebin, E. O'Reilly, V. Balachandran   +50 more
semanticscholar   +1 more source

Lrig1-expression confers suppressive function to CD4+ cells and is essential for averting autoimmunity via the Smad2/3/Foxp3 axis

Nature Communications, 2023
Regulatory T cells (Treg) are CD4+ T cells with immune-suppressive function, which is defined by Foxp3 expression. However, the molecular determinants defining the suppressive population of T cells have yet to be discovered.
Jae-Seung Moon, Chun-Chang Ho, Jong-Hyun Park, Kyungsoo Park, Bo-Young Shin, Su-Hyeon Lee, Ines Sequeira, Chin Hee Mun, Jin-Su Shin, Jung-Ho Kim, Beom Seok Kim, Jin-Wook Noh, Eui-Seon Lee, Ji Young Son, Yuna Kim, Yeji lee, Hee Cho, SunHyeon So, Jiyoon Park, Eunsu Choi, Jong-Won Oh, Sang-Won Lee, Tomohiro Morio, Fiona M. Watt, Rho Hyun Seong, Sang-Kyou Lee   +25 more
doaj   +1 more source

Age-Related Gene Alteration in Naïve and Memory T cells Using Precise Age-Tracking Model

Frontiers in Cell and Developmental Biology, 2021
In aged individuals, age-related changes in immune cells, especially T cell deficiency, are associated with an increased incidence of infection, tumor, and autoimmune disease, as well as an impaired response to vaccination.
Xiaofeng Yang, Xiaofeng Yang, Xiaofeng Yang, Xin Wang, Xin Wang, Xin Wang, Lei Lei, Lei Lei, Lei Lei, Lina Sun, Lina Sun, Anjun Jiao, Anjun Jiao, Anjun Jiao, Kun Zhu, Kun Zhu, Tao Xie, Tao Xie, Haiyan Liu, Haiyan Liu, Xingzhe Zhang, Xingzhe Zhang, Yanhong Su, Yanhong Su, Cangang Zhang, Cangang Zhang, Lin Shi, Lin Shi, Dan Zhang, Dan Zhang, Huiqiang Zheng, Huiqiang Zheng, Jiahui Zhang, Jiahui Zhang, Xiaobin Liu, Xiaobin Liu, Xin Wang, Xin Wang, Xiaobo Zhou, Xiaobo Zhou, Chenming Sun, Chenming Sun, Baojun Zhang, Baojun Zhang, Baojun Zhang   +44 more
doaj   +1 more source

Interplay between SMAD2 and STAT5A is a critical determinant of IL-17A/IL-17F differential expression

Molecular Biomedicine, 2021
Interleukins (IL)-17A and F are critical cytokines in anti-microbial immunity but also contribute to auto-immune pathologies. Recent evidence suggests that they may be differentially produced by T-helper (Th) cells, but the underlying mechanisms remain ...
Karla Fabiola Corral-Jara, Camille Chauvin, Wassim Abou-Jaoudé, Maximilien Grandclaudon, Aurélien Naldi, Vassili Soumelis, Denis Thieffry   +6 more
doaj   +1 more source

Determination of the level of CD4CD69 T cells in hemodialysis patients

Journal of Medicine in Scientific Research, 2022
Introduction The CD4 helper T cell is responsible for humoral, cellular immunity, and inflammation. CD69 may be a sensitive marker indicating that the CD4 T cell is activated.
Azza A I. Elmenyawi, Ahmed A A. Megeed, Nehad R Ibrahim, Mohamed Salah   +3 more
doaj   +1 more source

Metabolic support of tumor-infiltrating regulatory T cells by lactic acid

Nature, 2021
Regulatory T (Treg) cells, although vital for immune homeostasis, also represent a major barrier to anti-cancer immunity, as the tumour microenvironment (TME) promotes the recruitment, differentiation and activity of these cells1,2.
M. Watson, P. Vignali, S. Mullett, A. Overacre-Delgoffe, Ronal M. Peralta, Stephanie Grebinoski, Ashley V. Menk, Natalie L. Rittenhouse, Kristin DePeaux, Ryan D. Whetstone, D. Vignali, T. Hand, A. Poholek, Brett M. Morrison, J. Rothstein, S. Wendell, Greg M. Delgoffe   +16 more
semanticscholar   +1 more source

Deciphering the combinatorial landscape of immunity

eLife, 2020
From cellular activation to drug combinations, immunological responses are shaped by the action of multiple stimuli. Synergistic and antagonistic interactions between stimuli play major roles in shaping immune processes.
Antonio Cappuccio, Shane T Jensen, Boris M Hartmann, Stuart C Sealfon, Vassili Soumelis, Elena Zaslavsky   +5 more
doaj   +1 more source

Reduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19)

Frontiers in Immunology, 2020
Background: The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has posed great threat to human health.
Bo Diao, Chenhui Wang, Yi-ran Tan, Xie-Wan Chen, Ying Liu, Lifen Ning, Li Chen, Min Li, Yue-Ping Liu, Gang Wang, Zilin Yuan, Zeqing Feng, Yi Zhang, Yu-Zhang Wu, Yong-Wen Chen   +14 more
semanticscholar   +1 more source

Innate-like NKp30+CD8+ T cells armed with TCR/CAR target tumor heterogeneity

OncoImmunology, 2021
Intratumoral heterogeneity is frequently associated with tumor immune escape, with MHC-class I and antigen expression loss rendering tumor cells invisible to T cell killing, representing a major challenge for the design of successful adoptive transfer ...
Margareta P. Correia, Ana Stojanovic, Winfried S. Wels, Adelheid Cerwenka   +3 more
doaj   +1 more source

T cells in health and disease

Signal Transduction and Targeted Therapy, 2023
T cells are crucial for immune functions to maintain health and prevent disease. T cell development occurs in a stepwise process in the thymus and mainly generates CD4+ and CD8+ T cell subsets.
Lina Sun, Yan-Hong Su, Anjun Jiao, Xin Wang, Baojun Zhang   +4 more
semanticscholar   +1 more source