Results 41 to 50 of about 41,042,307 (363)
OncoImmunology, 2020 Immune checkpoint blockade (ICPB) is a powerfully effective cancer therapy in some patients. Tumor neo-antigens are likely main targets for attack but it is not clear which and how many tumor mutations in individual cancers are actually antigenic, with ...
Shaokang Ma +7 more
doaj +1 more source
Regulatory T cells and immune tolerance.
Cell, 2008 Regulatory T cells (Tregs) play an indispensable role in maintaining immunological unresponsiveness to self-antigens and in suppressing excessive immune responses deleterious to the host.
S. Sakaguchi +3 more
semanticscholar +1 more source
Cytotoxic CD8+ T cells in cancer and cancer immunotherapy
British Journal of Cancer, 2020 The functions of, and interactions between, the innate and adaptive immune systems are vital for anticancer immunity. Cytotoxic T cells expressing cell-surface CD8 are the most powerful effectors in the anticancer immune response and form the backbone of
H. Raskov +3 more
semanticscholar +1 more source
T Cell Hybrids with T Cell Functions
, 1979 Different T cell functions, e.g. help, suppression and cytotoxicity are associated with different T cell subsets, bearing distinctive differentiation markers. Thus effector T cells mediating help are Ly 1+2−3− and may bear Ia determinants, those mediating suppression are Ly 1−2+3+, IJ+, and cytotoxic cells are Ly 1−2+3+ and do not bear Ia determinants (
Simpson, E +8 more
openaire +3 more sources
STAR ProtocolsSummary: Yeast surface display is a versatile protein engineering technology, enabling precise control of the applied selection pressure. We present a yeast-surface-display-based protocol for the enrichment of binders specifically recognizing ligand ...
Markus Dobersberger +3 more
doaj +1 more source
T-cell based immunotherapies for Parkinson’s disease
Exploration of Neuroprotective Therapy, 2021 Current evidence indicates that neurodegeneration of dopaminergic neurons of the substantia nigra associated to Parkinson’s disease is a consequence of a neuroinflammatory process in which microglial cells play a central role.
Rodrigo Pacheco
doaj +1 more source
The potential role of T-cells and their interaction with antigen-presenting cells in mediating immunosuppression following trauma-hemorrhage [PDF]
, 2009 Objective: Trauma-hemorrhage results in depressed immune responses of antigen-presenting cells (APCs) and T-cells. Recent studies suggest a key role of depressed T-cell derived interferon (IFN)-g in this complex immune cell interaction.
Loehe, Florian +17 more
core +1 more source
Metabolic regulation of immune responses to cancer
Cancer Biology & Medicine, 2022 The tumor microenvironment is an ecosystem composed of multiple types of cells, such as tumor cells, immune cells, and cancer-associated fibroblasts. Cancer cells grow faster than non-cancerous cells and consume larger amounts of nutrients.
Jannis Wißfeld +4 more
doaj +1 more source
Responses of T cells to ligands for the T-cell receptor
Seminars in Immunology, 1996 We have learned a great deal about the recognition of MHC class II:peptide complexes by concentrating on the responses of a single cloned T-cell line, called D10. From these results, we argue for a single orientation of all CD4 T-cell receptors to their MHC ligands, based on the uneven top surface of MHC molecules, the repeated isolation of cells with ...
C A, Janeway, K, Bottomly
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The role of ICOS in the development of CD4 T cell help and the reactivation of memory T cells [PDF]
, 2007 We have addressed the role of the inducible costimulator (ICOS) in the development of T cell help for B cells and in the generation, survival and reactivation of memory CD4 T cells and B cells.
MacDonald, Andrew +18 more
core +1 more source