Results 41 to 50 of about 17,623,577 (306)

Tolerance without clonal expansion: self-antigen-expressing B cells program self-reactive T cells for future deletion [PDF]

, 2008
B cells have been shown in various animal models to induce immunological tolerance leading to reduced immune responses and protection from autoimmunity.
Müller, Werner, Frommer, Friederike, Heinen, Tobias J. A. J., Buch, Thorsten, Heinen, Tobias J A J, Anderton, Stephen M, Bettelli, Estelle, Waisman, Ari, Wunderlich, F Thomas, Mueller, Werner, Wunderlich, F. Thomas, Roers, Axel, Müller, Werner; id_orcid, Yogev, Nir, Anderton, Stephen M.   +14 more
core   +1 more source

T helper1/T helper2 cells and resistance/susceptibility to Leishmania infection : is this paradigm still relevant? [PDF]

, 2012
Work in large part on Leishmania major in the 1980s identified two distinct apparently counter-regulatory CD4 T cell populations, T helper (h)1 and Th2, that controlled resistance/susceptibility to infection respectively.
Brombacher, F., Alexander, J.
core   +4 more sources

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

A simple model system enabling human CD34+ cells to undertake differentiation towards T cells [PDF]

, 2013
Channelling the development of haematopoietic progenitor cells into T lymphocytes is dependent upon a series of extrinsic prompts whose temporal and spatial sequence is critical for a productive outcome.
B-Lynch Christopher, Lapenna, Antonio, Antonio Lapenna, Kapeni, Chrysa, Christopher B-Lynch, Richard Aspinall, Aspinall Richard, Kapeni Chrysa, B-Lynch, Christopher, Lapenna Antonio, Chrysa Kapeni, Aspinall, Richard   +11 more
core   +2 more sources

Solid Pseudopapillary Neoplasm of the Pancreas in Children and Adolescents: Expert Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Solid pseudopapillary neoplasm of the pancreas (SPN) is a rare low‐grade malignant exocrine pancreatic tumor, mostly discovered during the second decade of life in females, with a very good prognosis, provided microscopically complete surgical excision is achieved.
Sabine Irtan, Michael Abele, Calogero Virgone, Michaela Kuhlen, Ricardo Lopez‐Almarez, Tal Ben‐Ami, Ewa Bien, Maja Cesen, Malgorzata A. Krawczyk, Andrea Ferrari, Gianni Bisogno, Yves Reguerre, Dominik T. Schneider, Louise Galmiche, Jorg Fuchs, Sarah Braungart, Bilgehan Yalcin, Ines B. Brecht, Daniel Orbach   +18 more
wiley   +1 more source

Overcoming resistance to HER2-targeted therapy with a novel HER2/CD3 bispecific antibody

OncoImmunology, 2017
T-cell-based therapies have emerged as one of the most clinically effective ways to target solid and non-solid tumors. HER2 is responsible for the oncogenesis and treatment resistance of several human solid tumors.
Andres Lopez-Albaitero, Hong Xu, Hongfen Guo, Linlin Wang, Zhihao Wu, Hoa Tran, Sarat Chandarlapaty, Maurizio Scaltriti, Yelena Janjigian, Elisa de Stanchina, Nai-Kong V. Cheung   +10 more
doaj   +1 more source

Ovarian Sex Cord Stromal Tumors in Children and Adolescents—The European Standard Clinical Practice Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider, Kris‐Ann Schultz, Nora Schnitzler, Michael Abele, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Ines B. Brecht, Maja Cesen, Andrea Ferrari, Michaela Kuhlen, Malgorzata A. Krawczyk, Ricardo Lopez‐Almaraz, Yves Reguerre, Calogero Virgone, Daniel Orbach   +15 more
wiley   +1 more source

Apoptotic vesicles crossprime CD8 T cells and protect against tuberculosis. [PDF]

, 2006
CD8 T lymphocytes are important effectors in protective immunity against Mycobacterium tuberculosis. We recently characterized the detour pathway of CD8 T cell activation in tuberculosis mediated by apoptotic vesicles from infected cells that transport ...
Hoops, Silvia Locatelli, Subash Sad, Sandhoff, Konrad, de Diego, Juana, Konrad Sandhoff, Bernadette Breiden, Kaufmann, Stefan H. E., Juana de Diego, Winau, Florian, Weber, Stephan, Sad, Subash, Silvia Locatelli Hoops, Kaufmann, Stefan H.E., Kaufmann, Stefan HE, Ulrich E. Schaible, Volker Brinkmann, Florian Winau, Breiden, Bernadette, Brinkmann, Volker, Schaible, Ulrich E, Schaible, Ulrich E., Stephan Weber, Stefan H.E. Kaufmann   +22 more
core   +1 more source

Identifying Potential Diagnostic Genes for Diabetic Nephropathy Based on Hypoxia and Immune Status

Journal of Inflammation Research, 2021
Changyan Li,1 Feng Su,1 Le Zhang,2 Fang Liu,3 Wenxing Fan,1 Zhen Li,4 JingYuan Ma1 1Department of Nephrology, the First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, People’s Republic of China; 2Institute for Integrative ...
Li C, Su F, Zhang L, Liu F, Fan W, Li Z, Ma J   +6 more
doaj  

Acute Neurological Events in Children With Hemoglobin SC Disease: A Multicenter Retrospective Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Neurological manifestations in children with hemoglobin SC (HbSC) disease remain insufficiently characterized, particularly regarding acute events. The aim of this study was to describe the spectrum and frequency of acute neurological events in a multicenter cohort of children with HbSC disease.
Célia Paulmin, Bérengère Koehl, Audrey Maudoux, Hanine Mansour, Marie‐Hélène Odievre, Nathalie Garrec, Emilie Georget, Cécile Arnaud, Slimane Allali, Lydia Doumdo, Marie Belloy, Corinne Guitton   +11 more
wiley   +1 more source