Results 51 to 60 of about 3,681,633 (268)

Specific T-cell Activation in an Unspecific T-cell Repertoire [PDF]

Science Progress, 2011
T-cells are a vital type of white blood cell that circulate around our bodies, scanning for cellular abnormalities and infections. They recognise disease-associated antigens via a surface receptor called the T-cell antigen receptor (TCR). If there were a specific TCR for every single antigen, no mammal could possibly contain all the T-cells it needs ...
Berg, Hugo van den , Molina-Paris, Carmen, Sewell, Andrew K.   +2 more
openaire   +2 more sources

Improved Early Referral in Long‐Term Survivor Care With Institutional Standardized Practice Among Childhood Leukemia Survivors#

Pediatric Blood &Cancer, EarlyView.
ABSTRACT In 2018, the Texas Children's Cancer and Hematology Center Leukemia Program implemented a practice standard to support the transition from treatment to survivorship that includes shared, alternating care between leukemia and survivorship clinicians and a reminder to refer survivors to the long‐term survivor clinic (LTSC) 2 years after ...
Ji Yun Tark, Kayla L. Foster, Omar Shakeel, Mary C. Shapiro, Shawki L. Qasim, ZoAnn Dreyer, Eric S. Schafer, Ashley M. Butler, Austin L. Brown, Maria Monica Gramatges   +9 more
wiley   +1 more source

Effect of propofol induction on antioxidant defense system, cytokines, and cd4+ and cd8+ T cells in cats [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi
We investigated the effects of propofol on the antioxidant defense mechanisms, pro and anti-inflammatory cytokine expressions and specific defense processes in the study since these parameters play a significant role in postoperative complications ...
Didar AYDIN KAYA, Özlem GÜZEL, Duygu SEZER, Gülşen SEVİM, Erdal MATUR, Ezgi ERGEN, Feraye Esen GÜRSEL, Gizem ATMACA   +7 more
doaj   +1 more source

Personalized Zebrafish Models for Fusion‐Positive Pediatric Sarcomas

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Clinical sequencing efforts have revolutionized our approaches to categorizing pediatric cancers in real time. This has dramatically improved our ability to profile pediatric tumors, identify actionable vulnerabilities, and influence clinical care.
Lisa H. Hall, Emma N. Harrison, Genevieve C. Kendall   +2 more
wiley   +1 more source

Maternal microchimerism is prevalent in cord blood in memory T cells and other cell subsets, and persists post-transplant

OncoImmunology, 2017
Among reported advantages of umbilical cord blood (CB) in transplantation is lower leukemia relapse probability. Underlying cellular mechanisms of graft-vs.-leukemia (GVL) are thought to include a prominent role for T cells.
Sami B. Kanaan, Hilary S. Gammill, Whitney E. Harrington, Stephen C. De Rosa, Philip A. Stevenson, Alexandra M. Forsyth, Judy Allen, Emma Cousin, Koen van Besien, Colleen S. Delaney, J. Lee Nelson   +10 more
doaj   +1 more source

An Fc-inert PD-L1×4-1BB bispecific antibody mediates potent anti-tumor immunity in mice by combining checkpoint inhibition and conditional 4-1BB co-stimulation

OncoImmunology, 2022
Immune checkpoint inhibitors (ICI) targeting the PD-1/PD-L1 axis have changed the treatment paradigm for advanced solid tumors; however, many patients experience treatment resistance.
Alexander Muik, Isil Altintas, Friederike Gieseke, Kristina B Schoedel, Saskia M Burm, Aras Toker, Theodora W. Salcedo, Dennis Verzijl, David Eisel, Christian Grunwitz, Lena M Kranz, Mathias Vormehr, David P.E. Satijn, Mustafa Diken, Sebastian Kreiter, Kate Sasser, Tahamtan Ahmadi, Özlem Türeci, Esther C.W. Breij, Maria Jure-Kunkel, Ugur Sahin   +20 more
doaj   +1 more source

CAR-T Cell Therapy for T-Cell Malignancies.

Mediterranean journal of hematology and infectious diseases
Chimeric antigen receptor T-cell (CAR-T) therapy has revolutionized the treatment of B-cell lymphoid neoplasia and, in some instances, improved disease outcomes. Thus, six FDA-approved commercial CAR-T cell products that target antigens preferentially expressed on malignant B-cells or plasma cells have been introduced in the therapy of B-cell lymphomas,
Ugo Testa, Patrizia Chiusolo, Elvira Pelosi, Germana Castelli, Giuseppe Leone   +4 more
openaire   +3 more sources

The Role of “Adult‐Onset” Cancer Predisposition Genes in Pediatric Cancer: A Comprehensive Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Current literature estimates that 10% of pediatric cancers are caused by pathogenic or likely pathogenic (P/LP) germline variants in cancer predisposition genes (CPGs). Variants in CPGs thought to increase cancer risk exclusively during adulthood are referred to as “adult‐onset” CPGs (aoCPGs).
Maria Rozo, Miriam A. Bornhorst, Angela J. Waanders, Sara Zarnegar‐Lumley, Ashwin Lakshman Koppayi, Lucy A. Godley   +5 more
wiley   +1 more source

The Network of miRNA–mRNA Interactions in Circulating T Cells of Patients Following Major Trauma – A Pilot Study

Journal of Inflammation Research, 2022
Cheng-Shyuan Rau1 *, Pao-Jen Kuo2 *, Hui-Ping Lin,2 Chia-Jung Wu,2 Yi-Chan Wu,2 Peng-Chen Chien,2 Ting-Min Hsieh,3 Hang-Tsung Liu,3 Chun-Ying Huang,3 Ching-Hua Hsieh2 1Department of Neurosurgery, Kaohsiung Chang Gung Memorial Hospital and Chang ...
Rau CS, Kuo PJ, Lin HP, Wu CJ, Wu YC, Chien PC, Hsieh TM, Liu HT, Huang CY, Hsieh CH   +9 more
doaj  

Complex analysis of correlation interrelations between indicators of humoral and cellular immunity in persons vaccinated against plague

Инфекция и иммунитет, 2019
At present, the search for biomarkers, which indicate the presence of tense antiplague immunity, is continuing. The aim of the study was to determine the parameters of cellular and humoral immunity in persons vaccinated with the plague vaccine according ...
S. N. Klyueva, S. A. Bugorkova, A. Y. Goncharova, A. L. Kravtsov, O. M. Kudryavtseva, D. N. Sandzhiev, S. V. Konusheva, S. P. Savchenko, B. A. Khasykova, B. L. Agapov, S. A. Shcherbakova   +10 more
doaj   +1 more source