Results 51 to 60 of about 17,623,577 (306)
Non-hematopoietic cells in lymph nodes drive memory CD8 T cell inflation during murine cytomegalovirus infection. [PDF]
, 2011 During human and murine cytomegalovirus (MCMV) infection an exceptionally large virus-specific CD8 T cell pool is maintained in the periphery lifelong.
Torti, Nicole +15 more
core +2 more sources
The Pan African Medical Journal, 2018 Macrophage activation syndrome (MAS) is a severe and potentially fatal life-threatening condition associated with excessive activation and expansion of T cells with macrophages and a high expression of cytokines, resulting in an uncontrolled inflammatory
Zakia Sefsafi +4 more
doaj +1 more source
Role and specificity of regulatory T cells during retroviral infection [PDF]
, 2009 During chronic viral infection of the hematopoietic system, both virus-mediated and immune-mediated effects may cause bone marrow dysfunction leading to cytopenias. To study the pathological consequences of the T helper response to unresolving chronic
Antunes, I.L., Antunes, I L
core
Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNF alpha therapy [PDF]
, 2004 Regulatory T cells have been clearly implicated in the control of disease in murine models of autoimmunity. The paucity of data regarding the role of these lymphocytes in human autoimmune disease has prompted us to examine their function in patients with
Jamie G. Evans +13 more
core +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Embryonal tumors comprise the majority of malignant central nervous system (CNS) neoplasms diagnosed in children under 3 years of age. Compared with their counterparts in older children, these tumors exhibit distinct molecular biology and a more aggressive clinical phenotype, while their management is complicated by the heightened ...
Sudarshawn Damodharan +3 more
wiley +1 more source
Alpha (v) integrins license regulatory T cells to apoptotic cells and self-associated antigens [PDF]
, 2010 Defects in apoptotic cell clearance are thought to contribute to autoimmunity by failure to induce tolerance, coupled with accumulation of immunogenic material.
Paidassi, Helena +5 more
core +1 more source
Annales Academiae Medicae SilesiensisChimeric antigen receptor (CAR)-T cell therapy stands as an innovative treatment indicated for specific relapsed, refractory hematological malignancies and, increasingly, for solid tumors. Despite major therapy results in highlighted patient populations,
Maria Greniuk +3 more
doaj +1 more source
Role of Dendritic Cells in Exposing Latent HIV-1 for the Kill
Viruses, 2019 The development of effective yet nontoxic strategies to target the latent human immunodeficiency virus-1 (HIV-1) reservoir in antiretroviral therapy (ART)-suppressed individuals poses a critical barrier to a functional cure.
Jan Kristoff +2 more
doaj +1 more source
Responses of T cells to ligands for the T-cell receptor
Seminars in Immunology, 1996 We have learned a great deal about the recognition of MHC class II:peptide complexes by concentrating on the responses of a single cloned T-cell line, called D10. From these results, we argue for a single orientation of all CD4 T-cell receptors to their MHC ligands, based on the uneven top surface of MHC molecules, the repeated isolation of cells with ...
C A, Janeway, K, Bottomly
openaire +2 more sources
T-Cell Activation: Two for T [PDF]
Current Biology, 1995 T-cell activation requires costimulation in addition to the antigen-specific signal. Recent results suggest that distinct costimulatory molecules can specifically activate different types of T-cell response.
Guerder, Sylvie, Flavell, Richard A.
openaire +2 more sources